TY - JOUR
T1 - Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1
AU - Kuroda, Yudai
AU - Yamagata, Haruka
AU - Nemoto, Michiko
AU - Inagaki, Kenji
AU - Tamura, Takashi
AU - Maeda, Ken
N1 - Funding Information:
Acknowledgements This study was supported by grants from Japan Agency for Medical Research and Development (16fk0108117h0701) and by JSPS KAKENHI Grant Number 15H04599.
Publisher Copyright:
© 2019, The Author(s), under exclusive licence to the Japan Antibiotics Research Association.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Feline herpesvirus type 1 (FHV-1) causes a potentially fatal disease in cats. Through the use of virus inhibition and cytotoxicity assays, sinefungin, a nucleoside antibiotic, was assessed for its potential to inhibit the growth of FHV-1. Sinefungin inhibited in vitro growth of FHV-1 most significantly over other animal viruses, such as feline infectious peritonitis virus, equine herpesvirus, pseudorabies virus and feline calicivirus. Our results revealed that sinefungin specifically suppressed the replication of FHV-1 after its adsorption to the host feline kidney cells in a dose-dependent manner without obvious cytotoxicity to the host cells. This antibiotic can potentially offer a highly effective treatment for animals infected with FHV-1, providing alternative medication to currently available antiviral therapies.
AB - Feline herpesvirus type 1 (FHV-1) causes a potentially fatal disease in cats. Through the use of virus inhibition and cytotoxicity assays, sinefungin, a nucleoside antibiotic, was assessed for its potential to inhibit the growth of FHV-1. Sinefungin inhibited in vitro growth of FHV-1 most significantly over other animal viruses, such as feline infectious peritonitis virus, equine herpesvirus, pseudorabies virus and feline calicivirus. Our results revealed that sinefungin specifically suppressed the replication of FHV-1 after its adsorption to the host feline kidney cells in a dose-dependent manner without obvious cytotoxicity to the host cells. This antibiotic can potentially offer a highly effective treatment for animals infected with FHV-1, providing alternative medication to currently available antiviral therapies.
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U2 - 10.1038/s41429-019-0234-4
DO - 10.1038/s41429-019-0234-4
M3 - Article
C2 - 31534199
AN - SCOPUS:85074327129
SN - 0021-8820
VL - 72
SP - 981
EP - 985
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 12
ER -