TY - JOUR
T1 - Accumulation of Clostridium perfringens epsilon-toxin in the mouse kidney and its possible biological significance
AU - Tamai, Eiji
AU - Ishida, Tetsuya
AU - Miyata, Shigeru
AU - Matsushita, Osamu
AU - Suda, Hirofumi
AU - Kobayashi, Shoji
AU - Sonobe, Hiroshi
AU - Okabe, Akinobu
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.
AB - In this paper we show that Clostridium perfringens epsilon-toxin accumulates predominantly in the mouse kidney, where it is distributed mainly in glomeruli, capillaries, and collecting ducts. Although some pycnotic and exfoliated epithelial cells were observed in distal tubuli and collecting ducts, there were no findings indicative of severe renal injury. Bilateral nephrectomy increased the mouse lethality of the toxin, suggesting that the kidney contributes to the host defense against the lethal toxicity of epsilon-toxin.
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U2 - 10.1128/IAI.71.9.5371-5375.2003
DO - 10.1128/IAI.71.9.5371-5375.2003
M3 - Article
C2 - 12933886
AN - SCOPUS:0041823310
SN - 0019-9567
VL - 71
SP - 5371
EP - 5375
JO - Infection and Immunity
JF - Infection and Immunity
IS - 9
ER -
