TY - GEN

T1 - A robustness analysis of eukaryotic cell cycle concerning Cdc25 and weel proteins

AU - Azuma, Takehito

AU - Moriya, Hisao

AU - Matsumuro, Hayato

AU - Kitano, Hiroaki

PY - 2007

Y1 - 2007

N2 - This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Weel proteins. The robustness of the eukaryotic cell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Weel proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.

AB - This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Weel proteins. The robustness of the eukaryotic cell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Weel proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.

UR - http://www.scopus.com/inward/record.url?scp=43049181448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43049181448&partnerID=8YFLogxK

U2 - 10.1109/CCA.2006.286135

DO - 10.1109/CCA.2006.286135

M3 - Conference contribution

AN - SCOPUS:43049181448

SN - 0780397959

SN - 9780780397958

T3 - Proceedings of the IEEE International Conference on Control Applications

SP - 1734

EP - 1739

BT - Proceedings of the 2006 IEEE International Conference on Control Applications

T2 - Joint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC)

Y2 - 4 October 2006 through 6 October 2006

ER -