TY - GEN
T1 - A robustness analysis of eukaryotic cell cycle concerning Cdc25 and weel proteins
AU - Azuma, Takehito
AU - Moriya, Hisao
AU - Matsumuro, Hayato
AU - Kitano, Hiroaki
PY - 2007
Y1 - 2007
N2 - This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Weel proteins. The robustness of the eukaryotic cell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Weel proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.
AB - This paper discusses a robustness analysis of eukaryotic cell cycle and focuses on understanding functions of Cdc25 and Weel proteins. The robustness of the eukaryotic cell cycle is analyzed based on the sensitivity analysis for a mathematical model. From the first analysis result, it was shown that Cdc2 and Cyclin proteins have main roles for eukaryotic cell cycle in this model but the robustness is not high against perturbation on its parameters. By introducing Cdc25 and Weel proteins to the mathematical model, it was verified by the sensitivity analysis that the modified has higher level of robustnesses than the original model does. Numerical examples are shown to demonstrate the original model and the modified model have almost identical cell cycle behaviors leaving robustness as a salient difference.
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U2 - 10.1109/CCA.2006.286135
DO - 10.1109/CCA.2006.286135
M3 - Conference contribution
AN - SCOPUS:43049181448
SN - 0780397959
SN - 9780780397958
T3 - Proceedings of the IEEE International Conference on Control Applications
SP - 1734
EP - 1739
BT - Proceedings of the 2006 IEEE International Conference on Control Applications
T2 - Joint 2006 IEEE Conference on Control Applications (CCA), Computer-Aided Control Systems Design Symposium (CACSD) and International Symposium on Intelligent Control (ISIC)
Y2 - 4 October 2006 through 6 October 2006
ER -