A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

Mikako Ishiguro; Ryuta Takenaka; Kenichiro Ogura; Akira Hiratsuka; Hiromasa Takeda; Daisuke Kawai; Hirofumi Tsugeno; Shigeatsu Fujiki; Hiroyuki Okada

A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

Mikako Ishiguro, Ryuta Takenaka, Kenichiro Ogura, Akira Hiratsuka, Hiromasa Takeda, Daisuke Kawai, Hirofumi Tsugeno, Shigeatsu Fujiki, Hiroyuki Okada

研究成果 › 査読

1 被引用数 (Scopus)

抄録

A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.

本文言語	English
ページ（範囲）	557-562
ページ数	6
ジャーナル	Acta medica Okayama
巻	74
号	6
出版ステータス	Published - 2020

ASJC Scopus subject areas

生化学、遺伝学、分子生物学（全般）

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

他のファイルとリンク

引用スタイル

@article{f9dd7f409a224cb0a1490a7b21337185,

title = "A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants",

abstract = "A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.",

keywords = "5-fluorouracil, DPYD variant, dihydropyrimidine dehydrogenase deficiency, gastric cancer",

author = "Mikako Ishiguro and Ryuta Takenaka and Kenichiro Ogura and Akira Hiratsuka and Hiromasa Takeda and Daisuke Kawai and Hirofumi Tsugeno and Shigeatsu Fujiki and Hiroyuki Okada",

year = "2020",

language = "English",

volume = "74",

pages = "557--562",

journal = "Acta Medica Okayama",

issn = "0386-300X",

publisher = "Okayama University",

number = "6",

}

TY - JOUR

T1 - A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

AU - Ishiguro, Mikako

AU - Takenaka, Ryuta

AU - Ogura, Kenichiro

AU - Hiratsuka, Akira

AU - Takeda, Hiromasa

AU - Kawai, Daisuke

AU - Tsugeno, Hirofumi

AU - Fujiki, Shigeatsu

AU - Okada, Hiroyuki

PY - 2020

Y1 - 2020

N2 - A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.

AB - A 63-year-old Japanese male with stomach adenocarcinoma received oral 5-fluorouracil derivative, cisplatin and trastuzumab chemotherapy. On day 8, severe diarrhea and mucositis developed; chemotherapy was stopped. On day 14, the patient developed renal dysfunction and febrile neutropenia. He also suffered from pneumonia due to Candida albicans. Systemic symptoms improved after intensive conservative treatment. Best supportive care was continued until the patient died from gastric cancer. The dihydropyrimidine dehydrogenase protein level was low at 3.18 U/mg protein. The result of DPYD genotyping revealed three variants at positions 1615 (G>A), 1627 (A>G), and 1896 (T>C) in exons 13, 13, and 14, respectively.

KW - 5-fluorouracil

KW - DPYD variant

KW - dihydropyrimidine dehydrogenase deficiency

KW - gastric cancer

UR - http://www.scopus.com/inward/record.url?scp=85098700418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85098700418&partnerID=8YFLogxK

M3 - Article

C2 - 33361878

AN - SCOPUS:85098700418

SN - 0386-300X

VL - 74

SP - 557

EP - 562

JO - Acta Medica Okayama

JF - Acta Medica Okayama

IS - 6

ER -

A Japanese Patient with Gastric Cancer and Dihydropyrimidine Dehydrogenase Deficiency Presenting with DPYD Variants

抄録

ASJC Scopus subject areas

UN SDG

他のファイルとリンク

フィンガープリント

引用スタイル