@article{c4b53aecacbe458babe71abf3037fa44,
title = "A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses",
abstract = "Graft-versus-leukemia (GVL) response after allogeneic bone marrow transplantation (BMT) represents one of the most potent forms of immunotherapy against malignant diseases1. Antigen-presenting cells (APCs) are crucial for the induction of graft-versus-host disease (GVHD)2-6, the most serious complication of allogeneic BMT, but their role in GVL responses is unclear. Using a series of clinically relevant mouse GVL tumor models, we found that APCs and alloantigen expression on tumors are crucial for GVL. Moreover, APCs of host origin predominated in GVL responses although donor APCs contributed as the acuity of tumor burden decreased.",
author = "Pavan Reddy and Yoshinobu Maeda and Chen Liu and Krijanovski, {Oleg I.} and Robert Korngold and Ferrara, {James L.M.}",
note = "Funding Information: This work was supported by US National Institutes of Health grants K08 AI052863-01 (to P.R.), PO1 CA 49542 (to J.L.M.F.) and R01 HL55593 (to R.K). P.R. is the recipient of the Alaina J. Enlow Scholar Award from Amy Strelzer Manasevit – National Marrow Donor Program and the New Investigator Award from American Society of Blood and Marrow Transplantation. J.L.M.F. is a recipient of the Doris Duke Distinguished Clinical Scientist Award.",
year = "2005",
month = nov,
doi = "10.1038/nm1309",
language = "English",
volume = "11",
pages = "1244--1249",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "11",
}