A case of hyperammonemic encephalopathy in a patient with recurrent colon cancer treated with modified FOLFOX6

Fuminori Teraishi, Takeo Suzuki, Masako Nakamoto, Akira Chikuba, Masashi Nezu, Hiroshi Shimamura, Takamasa Watanabe, Tadakazu Matsuda, Takao Takiue, Hiroshi Chikuba

研究成果査読

4 被引用数 (Scopus)

抄録

FOLFOX therapy is a commonly used chemotherapeutic regimen against recurrent and unresectable colon cancer. However, its acute neurotoxicity is rare and not well recognized. We herein report a case of mFOLFOX6-induced hyperammonemic encephalopathy in a patient having recurrent colon cancer. A 74-year-old female with a history of sigmoid colon cancer was diagnosed as liver, lung, and peritoneal recurrences by surveillance CT and PET/CT. She was initially treated with modified FOLFOX6 therapy. After completing treatment, she presented with sudden onset of confusion, cognitive disturbances, and repeated seizures. None of the other radiographic examinations and laboratory tests provided an explanation for her symptoms except hyperammonemia. She was treated with branched-chain amino acid solutions and high-volume drip infusion, 6 hours after which the encephalopathy resolved. Clinicians should be aware of the adverse hyperammonemia induced by mFOLFOX6 when patients treated with mFOLFOX6 present with neurological disorders.

本文言語English
ページ(範囲)867-869
ページ数3
ジャーナルJapanese Journal of Cancer and Chemotherapy
36
5
出版ステータスPublished - 5月 2009
外部発表はい

ASJC Scopus subject areas

  • 医学(全般)

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