アスコルビン酸含有高張ポリエチレングリコール液およびグリセリン浣腸を用いた大腸カプセル内視鏡前処置の多施設前向き研究

Objective: Our objective was to evaluate the effectiveness of polyethylene glycol containing ascorbic acid (Asc-PEG) and glycerin enema (GE) as preparation for colon capsule endoscopy (CCE). Methods: We conducted a prospective multi-center study of patients who were scheduled to undergo CCE using Asc-PEG and GE as preparation. We evaluated visualization of the colon, excretion rate and associated factors, colonic polyp detection rate, and adverse events. Results: Eighty-two patients were analyzed. Adequate visualization of the entire colon was achieved in 82% (67/82). Capsules were excreted in 83% (68/82), and the mean small bowel transit time was significantly shorter in the group with successful excretion than in the group with unsuccessful excretion (p=0.025). GE was used in 27 cases (33%) and induced anus excretion in 78% (21/27) of cases. The colonic polyp detection rate was 49% (40/82). No adverse events were observed. Conclusion: Our regimen using Asc-PEG and GE seems to be a useful and safe preparation method for CCE.