Takehiko Yoshimitsu

2023

Organic redox cascade cyclization of 2-alkynylquinones by ascorbic acid in combination with a copper catalyst and its application to formal synthesis of liphagal

Jeong, T., Okanishi, Y., Yotsui, S., Kim, I. S. & Yoshimitsu, T., 2023, (Accepted/In press) In: New Journal of Chemistry.

研究成果 › 査読

2022

Radical-Based Route to Functionalized Tetralin: Formal Total Synthesis of (±)-Hamigeran B

Okanishi, Y., Ishikawa, T., Jinnouchi, T., Hayashi, S., Takanami, T., Aoyama, H. & Yoshimitsu, T., 2022, (Accepted/In press) In: Journal of Organic Chemistry.

研究成果 › 査読

2020

A virtual screening platform identifies chloroethylagelastatin a as a potential ribosomal inhibitor

Caulfield, T. R., Hayes, K. E., Qiu, Y., Coban, M., Oh, J. S., Lane, A. L., Yoshimitsu, T., Hazlehurst, L., Copland, J. A. & Tun, H. W., 10月 2020, In: Biomolecules. 10, 10, p. 1-19 19 p., 1407.

研究成果 › 査読

Open Access

1 被引用数 (Scopus)

Chemical syntheses and biological studies of agelastatin A, a bioactive marine heterocycle gifted from nature

Yoshimitsu, T., 2020, In: Heterocycles. 100, 11, p. 1735-1762 28 p.

研究成果 › 査読

Open Access

4 被引用数 (Scopus)

Total Synthesis of (±)-Liphagal via Organic-Redox-Driven Palladium-Catalyzed Hydroxybenzofuran Formation

Tao, E., Inoue, M., Jeong, T., Kim, I. S. & Yoshimitsu, T., 7月 17 2020, In: Journal of Organic Chemistry. 85, 14, p. 9064-9070 7 p.

研究成果 › 査読

2 被引用数 (Scopus)

2019

Strategic use of nitrogen free radicals in natural product synthesis: Total synthesis of agelastatin A

Yoshimitsu, T., 1月 1 2019, In: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 77, 5, p. 472-481 10 p.

研究成果 › 査読

1 被引用数 (Scopus)

2018

Ru(II)-Catalyzed C-H Aminocarbonylation of N -(Hetero)aryl-7-azaindoles with Isocyanates

Jeong, T., Lee, S. H., Chun, R., Han, S., Han, S. H., Jeon, Y. U., Park, J., Yoshimitsu, T., Mishra, N. K. & Kim, I. S., 4月 20 2018, In: Journal of Organic Chemistry. 83, 8, p. 4641-4649 9 p.

研究成果 › 査読

22 被引用数 (Scopus)

Total synthesis of (-)-agelastatin A: An S_H2′ radical azidation strategy

Tsuchimochi, I., Kitamura, Y., Aoyama, H., Akai, S., Nakai, K. & Yoshimitsu, T., 2018, In: Chemical Communications. 54, 71, p. 9893-9896 4 p.

研究成果 › 査読

10 被引用数 (Scopus)

Visceral adipose tissue drives cardiac aging through modulation of fibroblast senescence by osteopontin production

Sawaki, D., Czibik, G., Pini, M., Ternacle, J., Suffee, N., Mercedes, R., Marcelin, G., Surenaud, M., Marcos, E., Gual, P., Clément, K., Hue, S., Adnot, S., Hatem, S. N., Tsuchimochi, I., Yoshimitsu, T., Hénégar, C. & Derumeaux, G., 2018, In: Circulation. 138, 8, p. 809-822 14 p.

研究成果 › 査読

76 被引用数 (Scopus)

2017

2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice

Morihara, H., Obana, M., Tanaka, S., Kawakatsu, I., Tsuchiyama, D., Mori, S., Suizu, H., Ishida, A., Kimura, R., Tsuchimochi, I., Maeda, M., Yoshimitsu, T., Fujio, Y. & Nakayama, H., 12月 2017, In: PloS one. 12, 12, e0189948.

研究成果 › 査読

14 被引用数 (Scopus)

Compounds, compositions, and methods of agelastatin alkaloids: patent evaluation of WO2015042239 (A1)

Yoshimitsu, T. & Tun, H. W., 2月 1 2017, In: Expert Opinion on Therapeutic Patents. 27, 2, p. 113-119 7 p.

研究成果 › 査読

Regioselective Rearrangement of 4,4-Disubstituted 2-Hydroxycyclohexa-2,5-Dienones under Deoxyfluorination Conditions

Takubo, K., Mohamed, A., Ide, T., Saito, K., Ikawa, T., Yoshimitsu, T. & Akai, S., 12月 15 2017, In: Journal of Organic Chemistry. 82, 24, p. 13141-13151 11 p.

研究成果 › 査読

4 被引用数 (Scopus)

2016

Diversity Oriented Synthesis of Allocolchicinoids with Fluoro and/or Oxygen Substituent(s) on the C-Ring from a Single Common Intermediate

Takubo, K., Furutsu, K., Ide, T., Nemoto, H., Ueda, Y., Tsujikawa, K., Ikawa, T., Yoshimitsu, T. & Akai, S., 3月 1 2016, In: European Journal of Organic Chemistry. 2016, 8, p. 1562-1576 15 p.

研究成果 › 査読

12 被引用数 (Scopus)

2015

Total Synthesis of Clavilactone B: A Radical Cyclization-Fragmentation Strategy

Suizu, H., Shigeoka, D., Aoyama, H. & Yoshimitsu, T., 1月 2 2015, In: Organic Letters. 17, 1, p. 126-129 4 p.

研究成果 › 査読

19 被引用数 (Scopus)

2014

A new route to platencin via decarboxylative radical cyclization

Moustafa, G. A. I., Saku, Y., Aoyama, H. & Yoshimitsu, T., 11月 18 2014, In: Chemical Communications. 50, 99, p. 15706-15709 4 p.

研究成果 › 査読

9 被引用数 (Scopus)

Enantiospecific synthesis and cytotoxicity evaluation of ligudentatol: A programmed aromatization approach to the 2,3,4-trisubstituted phenolic motif via visible-light-mediated group transfer radical cyclization

Moustafa, G. A. I., Suizu, H., Aoyama, H., Arai, M., Akai, S. & Yoshimitsu, T., 6月 2014, In: Chemistry - An Asian Journal. 9, 6, p. 1506-1510 5 p.

研究成果 › 査読

2 被引用数 (Scopus)

Endeavors to access molecular complexity: Strategic use of free radicals in natural product synthesis

Yoshimitsu, T., 4月 2014, In: Chemical Record. 14, 2, p. 268-279 12 p.

研究成果 › 査読

2 被引用数 (Scopus)

2013

An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: Chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses

Li, Z., Shigeoka, D., Caulfield, T. R., Kawachi, T., Qiu, Y., Kamon, T., Arai, M., Tun, H. W. & Yoshimitsu, T., 7月 2013, In: MedChemComm. 4, 7, p. 1093-1098 6 p.

研究成果 › 査読

17 被引用数 (Scopus)

Dichlorination of olefins with NCS/Ph₃P

Kamada, Y., Kitamura, Y., Tanaka, T. & Yoshimitsu, T., 3月 14 2013, In: Organic and Biomolecular Chemistry. 11, 10, p. 1598-1601 4 p.

研究成果 › 査読

27 被引用数 (Scopus)

Formal synthesis of (-)-agelastatin A: An iron(II)-mediated cyclization strategy

Shigeoka, D., Kamon, T. & Yoshimitsu, T., 5月 3 2013, In: Beilstein Journal of Organic Chemistry. 9, p. 860-865 6 p.

研究成果 › 査読

19 被引用数 (Scopus)

Potent growth inhibitory activity of (±)-platencin towards multi-drug-resistant and extensively drug-resistant Mycobacterium tuberculosis

Moustafa, G. A. I., Nojima, S., Yamano, Y., Aono, A., Arai, M., Mitarai, S., Tanaka, T. & Yoshimitsu, T., 4月 2013, In: MedChemComm. 4, 4, p. 720-723 4 p.

研究成果 › 査読

18 被引用数 (Scopus)

Structure-activity relationships of hybrid annonaceous acetogenins: Powerful growth inhibitory effects of their connecting groups between heterocycle and hydrophobic carbon chain bearing THF ring on human cancer cell lines

Kojima, N., Fushimi, T., Tatsukawa, T., Yoshimitsu, T., Tanaka, T., Yamori, T., Dan, S., Iwasaki, H. & Yamashita, M., 2013, In: European Journal of Medicinal Chemistry. 63, p. 833-839 7 p.

研究成果 › 査読

19 被引用数 (Scopus)

2012

Double C-H functionalization in sequential order: Direct synthesis of polycyclic compounds by a palladium-catalyzed C-H alkenylation-arylation cascade

Ohno, H., Iuchi, M., Kojima, N., Yoshimitsu, T., Fujii, N. & Tanaka, T., 4月 23 2012, In: Chemistry - A European Journal. 18, 17, p. 5352-5360 9 p.

研究成果 › 査読

29 被引用数 (Scopus)

Intramolecular iron(ii)-catalyzed aminobromination of allyl N-tosyloxycarbamates

Kamon, T., Shigeoka, D., Tanaka, T. & Yoshimitsu, T., 3月 28 2012, In: Organic and Biomolecular Chemistry. 10, 12, p. 2363-2365 3 p.

研究成果 › 査読

16 被引用数 (Scopus)

Pharmacokinetics of Agelastatin A in the central nervous system

Li, Z., Kamon, T., Personett, D. A., Caulfield, T., Copland, J. A., Yoshimitsu, T. & Tun, H. W., 2月 2012, In: MedChemComm. 3, 2, p. 233-237 5 p.

研究成果 › 査読

15 被引用数 (Scopus)

Stereoconvergent route to chiral cyclohexenone building blocks: Formal synthesis of (-)-dysidiolide

Moustafa, G. A. I., Kamada, Y., Tanaka, T. & Yoshimitsu, T., 11月 21 2012, In: Organic and Biomolecular Chemistry. 10, 43, p. 8609-8615 7 p.

研究成果 › 査読

2 被引用数 (Scopus)

Stereoselective α-quaternization of 3-methoxycycloalk-2-enones via 1,4-diastereoinduction of alkoxy dienolates

Moustafa, G. A. I., Kamada, Y., Tanaka, T. & Yoshimitsu, T., 1月 20 2012, In: Journal of Organic Chemistry. 77, 2, p. 1202-1207 6 p.

研究成果 › 査読

6 被引用数 (Scopus)

2011

Asymmetric total synthesis of (+)-danicalipin A

Yoshimitsu, T., Nakatani, R., Kobayashi, A. & Tanaka, T., 3月 4 2011, In: Organic Letters. 13, 5, p. 908-911 4 p.

研究成果 › 査読

48 被引用数 (Scopus)

Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines

Kojima, N., Suga, Y., Hayashi, H., Yamori, T., Yoshimitsu, T. & Tanaka, T., 10月 1 2011, In: Bioorganic and Medicinal Chemistry Letters. 21, 19, p. 5745-5749 5 p.

研究成果 › 査読

14 被引用数 (Scopus)

Total synthesis of (±)-kainic acid: A photochemical C-H carbamoylation approach

Kamon, T., Irifune, Y., Tanaka, T. & Yoshimitsu, T., 5月 20 2011, In: Organic Letters. 13, 10, p. 2674-2677 4 p.

研究成果 › 査読

33 被引用数 (Scopus)

Total synthesis of (±)-platencin

Yoshimitsu, T., Nojima, S., Hashimoto, M. & Tanaka, T., 7月 15 2011, In: Organic Letters. 13, 14, p. 3698-3701 4 p.

研究成果 › 査読

40 被引用数 (Scopus)

2010

Asymmetric total synthesis of (+)-Hexachlorosulfolipid, a cytotoxin isolated from adriatic mussels

Yoshimitsu, T., Fukumoto, N., Nakatani, R., Kojima, N. & Tanaka, T., 8月 20 2010, In: Journal of Organic Chemistry. 75, 16, p. 5425-5437 13 p.

研究成果 › 査読

51 被引用数 (Scopus)

Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution

Kojima, N., Morioka, T., Urabe, D., Yano, M., Suga, Y., Maezaki, N., Ohashi-Kobayashi, A., Fujimoto, Y., Maeda, M., Yamori, T., Yoshimitsu, T. & Tanaka, T., 12月 15 2010, In: Bioorganic and Medicinal Chemistry. 18, 24, p. 8630-8641 12 p.

研究成果 › 査読

12 被引用数 (Scopus)

2009

Enantiocontrolled synthesis of polychlorinated hydrocarbon motifs: A nucleophilic multiple chlorination process revisited

Yoshimitsu, T., Fukumoto, N. & Tanaka, T., 1月 16 2009, In: Journal of Organic Chemistry. 74, 2, p. 696-702 7 p.

研究成果 › 査読

51 被引用数 (Scopus)

Studies of the asymmetric total synthesis of clavilactone D by the 'lariat' cyclization strategy

Yoshimitsu, T., Nojima, S., Hashimoto, M., Tsukamoto, K. & Tanaka, T., 11月 18 2009, In: Synthesis. 17, p. 2963-2969 7 p.

研究成果 › 査読

16 被引用数 (Scopus)

Synthesis of chaetomellic anhydride A, A potent inhibitor of ras protein farnesyltransferase

Yoshimitsu, T., Arano, Y., Kaji, T., Ino, T., Nagaoka, H. & Tanaka, T., 1月 1 2009, In: Heterocycles. 77, 1, p. 179-186 8 p.

研究成果 › 査読

11 被引用数 (Scopus)

Total synthesis of the β-caten in inhibitor, (-)-agelastatin A: A second-generation approach based on radical aminobromination

Yoshimitsu, T., Ino, T., Futamura, N., Kamon, T. & Tanaka, T., 8月 6 2009, In: Organic Letters. 11, 15, p. 3402-3405 4 p.

研究成果 › 査読

36 被引用数 (Scopus)

2008

Synthesis of (±)-aphanorphine: a new approach to tricyclic 3-benzazepine scaffold using two radical C-C bond-forming reactions

Yoshimitsu, T., Atsumi, C., Iimori, E., Nagaoka, H. & Tanaka, T., 7月 21 2008, In: Tetrahedron Letters. 49, 29-30, p. 4473-4475 3 p.

研究成果 › 査読

15 被引用数 (Scopus)

Total synthesis of (-)-agelastatin A

Yoshimitsu, T., Ino, T. & Tanaka, T., 2008, In: Organic Letters. 10, 23, p. 5457-5460 4 p.

研究成果 › 査読

64 被引用数 (Scopus)

2007

Radical fixation of functionalized carbon resources: α-sp ³C - H carbamoylation of tertiary amines with aryl isocyanates

Yoshimitsu, T., Matsuda, K., Nagaoka, H., Tsukamoto, K. & Tanaka, T., 11月 22 2007, In: Organic Letters. 9, 24, p. 5115-5118 4 p.

研究成果 › 査読

42 被引用数 (Scopus)

2005

Radical hydroxyalkylation of C-H bond adjacent to nitrogen of tertiary amides, ureas, and amines

Yoshimitsu, T., Arano, Y. & Nagaoka, H., 8月 24 2005, In: Journal of the American Chemical Society. 127, 33, p. 11610-11611 2 p.

研究成果 › 査読

67 被引用数 (Scopus)

Radical α-C-H hydroxyalkylation of ethers and acetal

Yoshimitsu, T., Arano, Y. & Nagaoka, H., 3月 18 2005, In: Journal of Organic Chemistry. 70, 6, p. 2342-2345 4 p.

研究成果 › 査読

44 被引用数 (Scopus)

2004

Studies on the total synthesis of (-)-CP-263,114

Yoshimitsu, T., Sasaki, S., Arano, Y. & Nagaoka, H., 12月 24 2004, In: Journal of Organic Chemistry. 69, 26, p. 9262-9268 7 p.

研究成果 › 査読

23 被引用数 (Scopus)

Total Synthesis of (+)-Muconin

Yoshimitsu, T., Makino, T. & Nagaoka, H., 3月 19 2004, In: Journal of Organic Chemistry. 69, 6, p. 1993-1998 6 p.

研究成果 › 査読

55 被引用数 (Scopus)

2003

Hydroxyalkylation of α-C-H bonds of tetrahydrofuran with aldehydes in the presence of triethylborane and tert-butyl hydroperoxide

Yoshimitsu, T., Arano, Y. & Nagaoka, H., 1月 24 2003, In: Journal of Organic Chemistry. 68, 2, p. 625-627 3 p.

研究成果 › 査読

40 被引用数 (Scopus)

Synthesis of (-)-muricatacin via α- and α′-C-H bond functionalization of tetrahydrofuran

Yoshimitsu, T., Makino, T. & Nagaoka, H., 9月 19 2003, In: Journal of Organic Chemistry. 68, 19, p. 7548-7550 3 p.

研究成果 › 査読

51 被引用数 (Scopus)

2002

Synthesis of the CD ring system of paclitaxel by atom-transfer radical annulation reaction

Yoshimitsu, T., Nakajima, H. & Nagaoka, H., 11月 18 2002, In: Tetrahedron Letters. 43, 47, p. 8587-8590 4 p.

研究成果 › 査読

15 被引用数 (Scopus)

2000

Asymmetric synthesis of the core structure of (-)-CP-263,114

Yoshimitsu, T., Yanagisawa, S. & Nagaoka, H., 11月 16 2000, In: Organic Letters. 2, 23, p. 3751-3754 4 p.

研究成果 › 査読

34 被引用数 (Scopus)

New route to the synthesis of the illudane skeleton by Michael-Michael- elimination reaction

Tokuzaki, K., Kanemitu, Y., Yoshimitsu, T. & Nagaoka, H., 7月 29 2000, In: Tetrahedron Letters. 41, 31, p. 5923-5926 4 p.

研究成果 › 査読

12 被引用数 (Scopus)

1999

An approach to the synthesis of CP-263,114: Complementary routes to the bicyclic ring system via two kinds of fragmentation reaction

Yoshimitsu, T., Yanagiya, M. & Nagaoka, H., 7月 9 1999, In: Tetrahedron Letters. 40, 28, p. 5215-5218 4 p.

研究成果 › 査読

44 被引用数 (Scopus)

Takehiko Yoshimitsu

研究成果

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