Zinc hydroxide stimulates superoxide production by rat alveolar macrophages

Keiki Ogino, Yukie Izumi, Hironobu Ishiyama, Tomoko Murata, Haruo Kobayashi, Tatsuya Houbara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of zinc hydroxide on superoxide (O2-) production by rat alveolar macrophages was determined by chemiluminescence and by cytochrome c reduction. Zinc ions had no effect on the chemiluminescence of unstimulated alveolar macrophages. By contrast, zinc hydroxide (ZnOH2), a neutralized form of zinc ions, increased the chemiluminescence level and O2- release. Increased O2- release was inhibited by pertussis toxin, isoquinoline sulfonamide and pretreatment with EGTA. These findings indicate that zinc hydroxide formation from zinc compounds can stimulate the O2- production by alveolar macrophages by receptor-mediated and Ca2+-dependent process.

Original languageEnglish
Pages (from-to)1115-1121
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume185
Issue number3
DOIs
Publication statusPublished - Jun 30 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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