Zinc-copper(I) chloride or -silver(I) acetate promoted aldol reaction of chlorodifluoromethyl ketones with carbonyl compounds. A general and effective route to α,α-difuluoro-β-hydroxy ketones

Manabu Kuroboshi, Takashi Ishihara

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Chlorodifluoromethyl ketones efficiently underwent the aldol reaction with a variety of aldehydes or ketones in the presence of zinc, a catalytic amount of copper(I) chloride or silver(I) acetate and molecular sieves to give the corresponding α,α-difluoro-β-hydroxy ketones in good to excellent yields.

Original languageEnglish
Pages (from-to)6481-6484
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number51
DOIs
Publication statusPublished - 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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