Chlorodifluoromethyl ketones efficiently underwent the aldol reaction with a variety of aldehydes or ketones in the presence of zinc, a catalytic amount of copper(I) chloride or silver(I) acetate and molecular sieves to give the corresponding α,α-difluoro-β-hydroxy ketones in good to excellent yields.
|Number of pages||4|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry