Zinc-copper(I) chloride or -silver(I) acetate promoted aldol reaction of chlorodifluoromethyl ketones with carbonyl compounds. A general and effective route to α,α-difuluoro-β-hydroxy ketones

Manabu Kuroboshi; Takashi Ishihara

doi:10.1016/S0040-4039(00)96894-1

Zinc-copper(I) chloride or -silver(I) acetate promoted aldol reaction of chlorodifluoromethyl ketones with carbonyl compounds. A general and effective route to α,α-difuluoro-β-hydroxy ketones

Manabu Kuroboshi, Takashi Ishihara

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Chlorodifluoromethyl ketones efficiently underwent the aldol reaction with a variety of aldehydes or ketones in the presence of zinc, a catalytic amount of copper(I) chloride or silver(I) acetate and molecular sieves to give the corresponding α,α-difluoro-β-hydroxy ketones in good to excellent yields.

Original language	English
Pages (from-to)	6481-6484
Number of pages	4
Journal	Tetrahedron Letters
Volume	28
Issue number	51
DOIs	https://doi.org/10.1016/S0040-4039(00)96894-1
Publication status	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)96894-1

Cite this

@article{54599d0244a441338bd28c3bb4cee961,

title = "Zinc-copper(I) chloride or -silver(I) acetate promoted aldol reaction of chlorodifluoromethyl ketones with carbonyl compounds. A general and effective route to α,α-difuluoro-β-hydroxy ketones",

abstract = "Chlorodifluoromethyl ketones efficiently underwent the aldol reaction with a variety of aldehydes or ketones in the presence of zinc, a catalytic amount of copper(I) chloride or silver(I) acetate and molecular sieves to give the corresponding α,α-difluoro-β-hydroxy ketones in good to excellent yields.",

author = "Manabu Kuroboshi and Takashi Ishihara",

year = "1987",

doi = "10.1016/S0040-4039(00)96894-1",

language = "English",

volume = "28",

pages = "6481--6484",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "51",

}

TY - JOUR

T1 - Zinc-copper(I) chloride or -silver(I) acetate promoted aldol reaction of chlorodifluoromethyl ketones with carbonyl compounds. A general and effective route to α,α-difuluoro-β-hydroxy ketones

AU - Kuroboshi, Manabu

AU - Ishihara, Takashi

PY - 1987

Y1 - 1987

N2 - Chlorodifluoromethyl ketones efficiently underwent the aldol reaction with a variety of aldehydes or ketones in the presence of zinc, a catalytic amount of copper(I) chloride or silver(I) acetate and molecular sieves to give the corresponding α,α-difluoro-β-hydroxy ketones in good to excellent yields.

AB - Chlorodifluoromethyl ketones efficiently underwent the aldol reaction with a variety of aldehydes or ketones in the presence of zinc, a catalytic amount of copper(I) chloride or silver(I) acetate and molecular sieves to give the corresponding α,α-difluoro-β-hydroxy ketones in good to excellent yields.

UR - http://www.scopus.com/inward/record.url?scp=0000504079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000504079&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)96894-1

DO - 10.1016/S0040-4039(00)96894-1

M3 - Article

AN - SCOPUS:0000504079

SN - 0040-4039

VL - 28

SP - 6481

EP - 6484

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 51

ER -

Zinc-copper(I) chloride or -silver(I) acetate promoted aldol reaction of chlorodifluoromethyl ketones with carbonyl compounds. A general and effective route to α,α-difuluoro-β-hydroxy ketones

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this