Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase

Toru Egashira, Kumiko Sakai, Fusako Takayama, Mami Sakurai, Satoshi Yoshida

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalToxicology Letters
Volume145
Issue number2
DOIs
Publication statusPublished - Nov 30 2003
Externally publishedYes

Fingerprint

Benzoates
Polystyrenes
Monoamine Oxidase
Zinc
Resins
Mitochondria
Brain
Haplorhini
Serotonin
Norepinephrine
Impurities
Chemical compounds
Water
Neurology
Boiling liquids
Amines
Rats
Central Nervous System
High Pressure Liquid Chromatography
Nuclear magnetic resonance

Keywords

  • Environmental compound
  • MAO-A
  • MAO-B
  • Monkey brain mitochondria
  • Zinc benzoate

ASJC Scopus subject areas

  • Toxicology

Cite this

Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase. / Egashira, Toru; Sakai, Kumiko; Takayama, Fusako; Sakurai, Mami; Yoshida, Satoshi.

In: Toxicology Letters, Vol. 145, No. 2, 30.11.2003, p. 161-165.

Research output: Contribution to journalArticle

Egashira, Toru ; Sakai, Kumiko ; Takayama, Fusako ; Sakurai, Mami ; Yoshida, Satoshi. / Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase. In: Toxicology Letters. 2003 ; Vol. 145, No. 2. pp. 161-165.
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