Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase

Toru Egashira; Kumiko Sakai; Fusako Takayama; Mami Sakurai; Satoshi Yoshida

doi:10.1016/S0378-4274(03)00286-8

Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase

Toru Egashira, Kumiko Sakai, Fusako Takayama, Mami Sakurai, Satoshi Yoshida

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Toxicology Letters
Volume	145
Issue number	2
DOIs	https://doi.org/10.1016/S0378-4274(03)00286-8
Publication status	Published - Nov 30 2003
Externally published	Yes

Keywords

Environmental compound
MAO-A
MAO-B
Monkey brain mitochondria
Zinc benzoate

ASJC Scopus subject areas

Toxicology

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title = "Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase",

abstract = "The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.",

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author = "Toru Egashira and Kumiko Sakai and Fusako Takayama and Mami Sakurai and Satoshi Yoshida",

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doi = "10.1016/S0378-4274(03)00286-8",

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T1 - Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase

AU - Egashira, Toru

AU - Sakai, Kumiko

AU - Takayama, Fusako

AU - Sakurai, Mami

AU - Yoshida, Satoshi

PY - 2003/11/30

Y1 - 2003/11/30

N2 - The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.

AB - The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.

KW - Environmental compound

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KW - Monkey brain mitochondria

KW - Zinc benzoate

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Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase

Abstract

Keywords

ASJC Scopus subject areas

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