Abstract
The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.
Original language | English |
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Pages (from-to) | 161-165 |
Number of pages | 5 |
Journal | Toxicology Letters |
Volume | 145 |
Issue number | 2 |
DOIs | |
Publication status | Published - Nov 30 2003 |
Externally published | Yes |
Keywords
- Environmental compound
- MAO-A
- MAO-B
- Monkey brain mitochondria
- Zinc benzoate
ASJC Scopus subject areas
- Toxicology