Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors

a study from the Japanese Breast Cancer Registry

Akemi Kataoka, Takayuki Iwamoto, Eriko Tokunaga, Ai Tomotaki, Hiraku Kumamaru, Hiroaki Miyata, Naoki Niikura, Masaaki Kawai, Keisei Anan, Naoki Hayashi, Shinobu Masuda, Koichiro Tsugawa, Kenjiro Aogi, Takanori Ishida, Hideji Masuoka, Kotaro Iijima, Takayuki Kinoshita, Seigo Nakamura, Yutaka Tokuda

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors. Methods: Of the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients (48.3 %), who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult (YA; <35 years), middle-aged adult (MA; 35–50 years), and older adult (OA; >50 years) patients. Five-year disease-free survival (DFS) and overall survival (OS) rates were studied. Results: YA patients were associated with an advanced TNM stage and aggressive characteristics (e.g. human epidermal growth factor receptor 2 (HER2)-positive or oestrogen receptor (ER)-negative breast cancers) compared to MA and OA patients (P < 0.001). The 5-year DFS and OS rates were 79.4 % and 90.8, 88.5 and 95.0 %, and 87.8 % and 91.6 % for YA, MA, and OA patients, respectively. From the multivariable regression analysis, young age at onset was confirmed as an independent prognostic factor for both DFS (hazard ratio 1.73, 95 % confidence interval 1.42–2.10; P < 0.001) and OS (hazard ratio 1.58, 95 % confidence interval 1.16–2.15; P = 0.004). Conclusions: Young age at onset is an independent negative prognostic factor in breast cancer. Further studies are required to develop new therapeutic strategies for YA breast cancer patients.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalBreast Cancer Research and Treatment
Volume160
Issue number1
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Registries
Young Adult
Breast Neoplasms
Age of Onset
Disease-Free Survival
Survival Rate
Confidence Intervals
Estrogen Receptors
Regression Analysis
Survival

Keywords

  • Breast cancer
  • Multivariable analysis
  • Prognosis
  • Surveillance data
  • Young women

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors : a study from the Japanese Breast Cancer Registry. / Kataoka, Akemi; Iwamoto, Takayuki; Tokunaga, Eriko; Tomotaki, Ai; Kumamaru, Hiraku; Miyata, Hiroaki; Niikura, Naoki; Kawai, Masaaki; Anan, Keisei; Hayashi, Naoki; Masuda, Shinobu; Tsugawa, Koichiro; Aogi, Kenjiro; Ishida, Takanori; Masuoka, Hideji; Iijima, Kotaro; Kinoshita, Takayuki; Nakamura, Seigo; Tokuda, Yutaka.

In: Breast Cancer Research and Treatment, Vol. 160, No. 1, 01.11.2016, p. 163-172.

Research output: Contribution to journalArticle

Kataoka, A, Iwamoto, T, Tokunaga, E, Tomotaki, A, Kumamaru, H, Miyata, H, Niikura, N, Kawai, M, Anan, K, Hayashi, N, Masuda, S, Tsugawa, K, Aogi, K, Ishida, T, Masuoka, H, Iijima, K, Kinoshita, T, Nakamura, S & Tokuda, Y 2016, 'Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry', Breast Cancer Research and Treatment, vol. 160, no. 1, pp. 163-172. https://doi.org/10.1007/s10549-016-3984-8
Kataoka, Akemi ; Iwamoto, Takayuki ; Tokunaga, Eriko ; Tomotaki, Ai ; Kumamaru, Hiraku ; Miyata, Hiroaki ; Niikura, Naoki ; Kawai, Masaaki ; Anan, Keisei ; Hayashi, Naoki ; Masuda, Shinobu ; Tsugawa, Koichiro ; Aogi, Kenjiro ; Ishida, Takanori ; Masuoka, Hideji ; Iijima, Kotaro ; Kinoshita, Takayuki ; Nakamura, Seigo ; Tokuda, Yutaka. / Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors : a study from the Japanese Breast Cancer Registry. In: Breast Cancer Research and Treatment. 2016 ; Vol. 160, No. 1. pp. 163-172.
@article{abf0122ff5e944b9b2b13d9dd826d2e8,
title = "Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors: a study from the Japanese Breast Cancer Registry",
abstract = "Purpose: The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors. Methods: Of the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients (48.3 {\%}), who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult (YA; <35 years), middle-aged adult (MA; 35–50 years), and older adult (OA; >50 years) patients. Five-year disease-free survival (DFS) and overall survival (OS) rates were studied. Results: YA patients were associated with an advanced TNM stage and aggressive characteristics (e.g. human epidermal growth factor receptor 2 (HER2)-positive or oestrogen receptor (ER)-negative breast cancers) compared to MA and OA patients (P < 0.001). The 5-year DFS and OS rates were 79.4 {\%} and 90.8, 88.5 and 95.0 {\%}, and 87.8 {\%} and 91.6 {\%} for YA, MA, and OA patients, respectively. From the multivariable regression analysis, young age at onset was confirmed as an independent prognostic factor for both DFS (hazard ratio 1.73, 95 {\%} confidence interval 1.42–2.10; P < 0.001) and OS (hazard ratio 1.58, 95 {\%} confidence interval 1.16–2.15; P = 0.004). Conclusions: Young age at onset is an independent negative prognostic factor in breast cancer. Further studies are required to develop new therapeutic strategies for YA breast cancer patients.",
keywords = "Breast cancer, Multivariable analysis, Prognosis, Surveillance data, Young women",
author = "Akemi Kataoka and Takayuki Iwamoto and Eriko Tokunaga and Ai Tomotaki and Hiraku Kumamaru and Hiroaki Miyata and Naoki Niikura and Masaaki Kawai and Keisei Anan and Naoki Hayashi and Shinobu Masuda and Koichiro Tsugawa and Kenjiro Aogi and Takanori Ishida and Hideji Masuoka and Kotaro Iijima and Takayuki Kinoshita and Seigo Nakamura and Yutaka Tokuda",
year = "2016",
month = "11",
day = "1",
doi = "10.1007/s10549-016-3984-8",
language = "English",
volume = "160",
pages = "163--172",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Young adult breast cancer patients have a poor prognosis independent of prognostic clinicopathological factors

T2 - a study from the Japanese Breast Cancer Registry

AU - Kataoka, Akemi

AU - Iwamoto, Takayuki

AU - Tokunaga, Eriko

AU - Tomotaki, Ai

AU - Kumamaru, Hiraku

AU - Miyata, Hiroaki

AU - Niikura, Naoki

AU - Kawai, Masaaki

AU - Anan, Keisei

AU - Hayashi, Naoki

AU - Masuda, Shinobu

AU - Tsugawa, Koichiro

AU - Aogi, Kenjiro

AU - Ishida, Takanori

AU - Masuoka, Hideji

AU - Iijima, Kotaro

AU - Kinoshita, Takayuki

AU - Nakamura, Seigo

AU - Tokuda, Yutaka

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Purpose: The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors. Methods: Of the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients (48.3 %), who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult (YA; <35 years), middle-aged adult (MA; 35–50 years), and older adult (OA; >50 years) patients. Five-year disease-free survival (DFS) and overall survival (OS) rates were studied. Results: YA patients were associated with an advanced TNM stage and aggressive characteristics (e.g. human epidermal growth factor receptor 2 (HER2)-positive or oestrogen receptor (ER)-negative breast cancers) compared to MA and OA patients (P < 0.001). The 5-year DFS and OS rates were 79.4 % and 90.8, 88.5 and 95.0 %, and 87.8 % and 91.6 % for YA, MA, and OA patients, respectively. From the multivariable regression analysis, young age at onset was confirmed as an independent prognostic factor for both DFS (hazard ratio 1.73, 95 % confidence interval 1.42–2.10; P < 0.001) and OS (hazard ratio 1.58, 95 % confidence interval 1.16–2.15; P = 0.004). Conclusions: Young age at onset is an independent negative prognostic factor in breast cancer. Further studies are required to develop new therapeutic strategies for YA breast cancer patients.

AB - Purpose: The aim of this study was to investigate whether young age at onset of breast cancer is an independent prognostic factor in patients from the Japanese Breast Cancer Registry, after adjustment of known clinicopathological prognostic factors. Methods: Of the 53,670 patients registered between 2004 and 2006 and surveyed after a 5-year follow-up prognosis, 25,898 breast cancer patients (48.3 %), who were obtained prognostic data, were examined. Clinicopathological factors were compared between young adult (YA; <35 years), middle-aged adult (MA; 35–50 years), and older adult (OA; >50 years) patients. Five-year disease-free survival (DFS) and overall survival (OS) rates were studied. Results: YA patients were associated with an advanced TNM stage and aggressive characteristics (e.g. human epidermal growth factor receptor 2 (HER2)-positive or oestrogen receptor (ER)-negative breast cancers) compared to MA and OA patients (P < 0.001). The 5-year DFS and OS rates were 79.4 % and 90.8, 88.5 and 95.0 %, and 87.8 % and 91.6 % for YA, MA, and OA patients, respectively. From the multivariable regression analysis, young age at onset was confirmed as an independent prognostic factor for both DFS (hazard ratio 1.73, 95 % confidence interval 1.42–2.10; P < 0.001) and OS (hazard ratio 1.58, 95 % confidence interval 1.16–2.15; P = 0.004). Conclusions: Young age at onset is an independent negative prognostic factor in breast cancer. Further studies are required to develop new therapeutic strategies for YA breast cancer patients.

KW - Breast cancer

KW - Multivariable analysis

KW - Prognosis

KW - Surveillance data

KW - Young women

UR - http://www.scopus.com/inward/record.url?scp=84988434146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988434146&partnerID=8YFLogxK

U2 - 10.1007/s10549-016-3984-8

DO - 10.1007/s10549-016-3984-8

M3 - Article

VL - 160

SP - 163

EP - 172

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 1

ER -