Yearly changes in antibacterial activities of cefozopran against various clinical isolates between 1996 and 2000: II. Gram-negative bacteria

Yumiko Suzuki, Chisato Nishinari, Harumi Endo, Chieko Tamura, Keiko Jinbo, Nobuyoshi Hiramatsu, Kazumitsu Akiyama, Tsuneo Koyama

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Abstract

The in vitro antibacterial activities of cefozopran (CZOP), an agent of cephems, against various clinical isolates obtained between 1996 and 2000 were yearly evaluated and compared with those of other cephems, oxacephems, and carbapenems. Thirty-two species 2,697 strains of Gram-negative bacteria were isolated from the clinical materials annually collected from January to December, and consisted of Moraxella subgenus Branhamella catarrhalis (n=125), Escherichia coli (n=250), Citrobacter freundii (n=153), Citrobacter koseri (n=97), Klebsiella pneumoniae (n=150), Klebsiella oxytoca (n=100), Enterobacter aerogenes (n=50), Enterobacter cloacae (n=125), Serratia marcescens (n=153), Proteus mirabillis (n=103), Proteus vulgaris (n=77), Morganella morganii (n=141), Providencia spp. (P alcalifaciens, P. rettgeri, P stuartii; n=154), Pseudomonas aeruginosa (n=211), Pseudomonas putida (n=49), Burkholderia cepacia (n=102), Stenotrophomonas maltophilia (n=101), Haemophilus influenzae (n=210), Acinetobactor baumannii (n=63), Acinetobactor lwoffii (n=30), Bacteroides fragilis group (B. fragilis, B. vulgatus, B. distasonis, B. ovatus, B. thetaiotaomicron; n=129), and Prevotella spp. (P. melaninogenica, P intermedia, P bivia, P oralis, P denticola; n=124). CZOP possessed stable antibacterial activities against M. (B.) catarrhalis, E. coli, C. freundii, C. koseri, K. pneumoniae, K. oxytoca, E. aerogenes, E. cloacae, S. marcescens, P mirabilis, P vulgaris, M. morganii, Providencia spp., P. aeruginosa, and A. Iwoffii throughout 5 years. The MIC90 of CZOP against those strains were consistent with those obtained from the studies performed until the new drug application approval. On the other hand, the MIC90 of CZOP against H. influenzae yearly obviously increased with approximately 65-time difference during study period. The MIC90 of cefpirome, cefepime, and flomoxef against H. influenzae also yearly tended to rise. The present results demonstrated that CZOP had maintained the antibacterial activity against almost Gram-negative strains tested. However, the decrease in the antibacterial activity of CZOP against H. influenzae was suggested.

Original languageEnglish
Pages (from-to)154-180
Number of pages27
JournalJapanese Journal of Antibiotics
Volume55
Issue number2
Publication statusPublished - May 21 2002

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Suzuki, Y., Nishinari, C., Endo, H., Tamura, C., Jinbo, K., Hiramatsu, N., Akiyama, K., & Koyama, T. (2002). Yearly changes in antibacterial activities of cefozopran against various clinical isolates between 1996 and 2000: II. Gram-negative bacteria. Japanese Journal of Antibiotics, 55(2), 154-180.