Abstract
Foetal rat mesencephalic dopamine-containing tissue was transplanted into the lateral ventricle of mice previously subjected to a 6-OHDA lesion of dopaminergic nerve terminals in the corpus striatum. The graft recipients were immunosuppressed by subcutaneous injections of 15-deoxy-spergualin (DSG). Four weeks postgrafting, all DSG-treated mice showed partial or complete functional compensation in amphetamine-induced motor asymmetry. The immunohistochemical staining of tyrosine hydroxylase (TH) revealed large numbers of surviving dopamine neurons and abundant fibers in the grafted animals. In contrast, all grafts in non-DSG-treated animals were rejected and functional compensation was lacking. It is concluded that DSG treatment promotes xenogeneic intracerebral graft survival, recovery of function and reduce the histological sign of rejection.
| Original language | English |
|---|---|
| Pages (from-to) | 81-84 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 163 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Nov 26 1993 |
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Keywords
- 15-Deoxyspergualin
- Dopamine
- Immunosuppressant
- Neural transplantation
- Parkinson's disease
- Rodent
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Xenogeneic dopaminergic grafts reverse behavioral deficits induced by 6-OHDA in rodents : Effect of 15-deoxyspergualin treatment. / Zhou, Jiawei; Date, Isao; Sakai, Kyoji; Yoshimoto, Yusuke; Furuta, Tomohisa; Asari, Shoji; Ohmoto, Takashi.
In: Neuroscience Letters, Vol. 163, No. 1, 26.11.1993, p. 81-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Xenogeneic dopaminergic grafts reverse behavioral deficits induced by 6-OHDA in rodents
T2 - Effect of 15-deoxyspergualin treatment
AU - Zhou, Jiawei
AU - Date, Isao
AU - Sakai, Kyoji
AU - Yoshimoto, Yusuke
AU - Furuta, Tomohisa
AU - Asari, Shoji
AU - Ohmoto, Takashi
PY - 1993/11/26
Y1 - 1993/11/26
N2 - Foetal rat mesencephalic dopamine-containing tissue was transplanted into the lateral ventricle of mice previously subjected to a 6-OHDA lesion of dopaminergic nerve terminals in the corpus striatum. The graft recipients were immunosuppressed by subcutaneous injections of 15-deoxy-spergualin (DSG). Four weeks postgrafting, all DSG-treated mice showed partial or complete functional compensation in amphetamine-induced motor asymmetry. The immunohistochemical staining of tyrosine hydroxylase (TH) revealed large numbers of surviving dopamine neurons and abundant fibers in the grafted animals. In contrast, all grafts in non-DSG-treated animals were rejected and functional compensation was lacking. It is concluded that DSG treatment promotes xenogeneic intracerebral graft survival, recovery of function and reduce the histological sign of rejection.
AB - Foetal rat mesencephalic dopamine-containing tissue was transplanted into the lateral ventricle of mice previously subjected to a 6-OHDA lesion of dopaminergic nerve terminals in the corpus striatum. The graft recipients were immunosuppressed by subcutaneous injections of 15-deoxy-spergualin (DSG). Four weeks postgrafting, all DSG-treated mice showed partial or complete functional compensation in amphetamine-induced motor asymmetry. The immunohistochemical staining of tyrosine hydroxylase (TH) revealed large numbers of surviving dopamine neurons and abundant fibers in the grafted animals. In contrast, all grafts in non-DSG-treated animals were rejected and functional compensation was lacking. It is concluded that DSG treatment promotes xenogeneic intracerebral graft survival, recovery of function and reduce the histological sign of rejection.
KW - 15-Deoxyspergualin
KW - Dopamine
KW - Immunosuppressant
KW - Neural transplantation
KW - Parkinson's disease
KW - Rodent
UR - http://www.scopus.com/inward/record.url?scp=0027379931&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027379931&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(93)90234-C
DO - 10.1016/0304-3940(93)90234-C
M3 - Article
VL - 163
SP - 81
EP - 84
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -