X-ray dark-field Imaging and potential of its clinical application

Daisuke Shimao, Hiroshi Sugiyama, Toshiyuki Kunisada, Anton Maksimenko, Fukai Toyofuku, Ei Ueno, Katsuhito Yamasaki, Chiho Obayashi, Kazuyuki Hyodo, Gang Li, Lin Pan, Xiaoming Jiang, Masami Ando

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

X-ray dark-field imaging (DFI) due to refraction is under development with intension of its clinical application. In this system we have adopted an asymmetric-cut monochro-collimator (M) and an angular analyzer (A) of Si 440 diffraction at around 35 keV of X-rays. By choosing an appropriate thickness T of A that satisfies the condition T = λN where λ is the extinction distance and N integer the transmissivity in the region of |W| (angular parameter) <1 should be theoretically almost zero and |W| > 1 should be approximately 70-80%. This has been experimentally proven. Under this condition the X-rays whose propagation direction may not change such as those receiving only absorption will not go into the forward diffraction direction after A but go into the diffraction direction, while the X-rays refracted by object may go into the forward diffraction direction after A. We have settled two targets of clinical views: soft tissues at joints and early check of breast cancer. A first clear image of articular cartilage of small joint was successfully obtained using a proximal interphalangeal joint that was amputated from a cadaver. Since larger view field is needed for clinical use the size of approximately 90 mm in square has been successfully achieved. Using this beam articular cartilage of knee and shoulder joints from the same cadaver have been successfully visualized. Further visibility test by the DFI is under way for a phantom of breast cancer, paraffin fixed sliced breast samples containing micro-calcification, tumor and excised breast tissue.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsM.J. Flynn
Pages32-39
Number of pages8
Volume5745
EditionI
DOIs
Publication statusPublished - 2005
EventMedical Imaging 2005 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 13 2005Feb 15 2005

Other

OtherMedical Imaging 2005 - Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/13/052/15/05

Fingerprint

Diffraction
Imaging techniques
X rays
Cartilage
Tissue
Refraction
Visibility
Paraffins
Tumors

Keywords

  • Analyzer
  • Articular cartilage
  • Breast cancer
  • Monochro-collimator
  • Synchrotron radiation
  • Vertical wiggler
  • X-ray dark-field imaging

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Shimao, D., Sugiyama, H., Kunisada, T., Maksimenko, A., Toyofuku, F., Ueno, E., ... Ando, M. (2005). X-ray dark-field Imaging and potential of its clinical application. In M. J. Flynn (Ed.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (I ed., Vol. 5745, pp. 32-39). [05] https://doi.org/10.1117/12.595021

X-ray dark-field Imaging and potential of its clinical application. / Shimao, Daisuke; Sugiyama, Hiroshi; Kunisada, Toshiyuki; Maksimenko, Anton; Toyofuku, Fukai; Ueno, Ei; Yamasaki, Katsuhito; Obayashi, Chiho; Hyodo, Kazuyuki; Li, Gang; Pan, Lin; Jiang, Xiaoming; Ando, Masami.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / M.J. Flynn. Vol. 5745 I. ed. 2005. p. 32-39 05.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shimao, D, Sugiyama, H, Kunisada, T, Maksimenko, A, Toyofuku, F, Ueno, E, Yamasaki, K, Obayashi, C, Hyodo, K, Li, G, Pan, L, Jiang, X & Ando, M 2005, X-ray dark-field Imaging and potential of its clinical application. in MJ Flynn (ed.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. I edn, vol. 5745, 05, pp. 32-39, Medical Imaging 2005 - Physics of Medical Imaging, San Diego, CA, United States, 2/13/05. https://doi.org/10.1117/12.595021
Shimao D, Sugiyama H, Kunisada T, Maksimenko A, Toyofuku F, Ueno E et al. X-ray dark-field Imaging and potential of its clinical application. In Flynn MJ, editor, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. I ed. Vol. 5745. 2005. p. 32-39. 05 https://doi.org/10.1117/12.595021
Shimao, Daisuke ; Sugiyama, Hiroshi ; Kunisada, Toshiyuki ; Maksimenko, Anton ; Toyofuku, Fukai ; Ueno, Ei ; Yamasaki, Katsuhito ; Obayashi, Chiho ; Hyodo, Kazuyuki ; Li, Gang ; Pan, Lin ; Jiang, Xiaoming ; Ando, Masami. / X-ray dark-field Imaging and potential of its clinical application. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / M.J. Flynn. Vol. 5745 I. ed. 2005. pp. 32-39
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