Wound complications following pre-operative radiotherapy for soft tissue sarcoma

Toshiyuki Kunisada, S. Y. Ngan, G. Powell, Peter F M Choong

Research output: Contribution to journalArticle

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Abstract

Aims: We analysed wound complications in 43 patients with soft tissue sarcoma who were treated with combined pre-operative radiotherapy and surgery. Methods: All patients received the same protocol of pre-operative radiotherapy at our institution. Results: Thirty-six (84%) patients developed acute skin toxicity following radiotherapy. After wide local excision, 15 patients required primary soft tissue reconstruction with vascularized muscle transfer and four patients underwent free skin flap to enable wound closure as part of their primary surgery. Nineteen patients (44%) developed post-operative wound complications including 10 (23%) patients who required an additional surgical procedure. Four (27%) patients developed flap necrosis in a group of 15 who underwent primary vascularized soft tissue transfer. All required a second vascularized muscular flap. One elderly patient, who had grade 3 acute radiation skin toxicity, had an arterial graft and total hip arthroplasty for a femoral artery aneurysm and an avascular necrosis of the hip, respectively. In our series, age (≥40 years) was the only impact factor influencing wound complication after surgery following radiotherapy (P = 0.06). Conclusions: Site of tumour, radiation field size, surgical resection volume, grade of acute radiation toxicity, comorbidity, and smoking were not demonstrated to have predictive value in wound complication following pre-operative radiotherapy. Although previous papers suggested that vascularized soft tissue transfer could be useful reducing wound morbidity, our results could not confirm this.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalEuropean Journal of Surgical Oncology
Volume28
Issue number1
DOIs
Publication statusPublished - Feb 2002
Externally publishedYes

Fingerprint

Sarcoma
Radiotherapy
Wounds and Injuries
Radiation
Skin
Hip
Necrosis
Patient Transfer
Free Tissue Flaps
Femoral Artery
Arthroplasty
Aneurysm
Comorbidity
Smoking
Morbidity
Transplants
Muscles
Neoplasms

Keywords

  • Pre-operative radiotherapy
  • Soft tissue sarcoma
  • Surgery
  • Wound complication

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Wound complications following pre-operative radiotherapy for soft tissue sarcoma. / Kunisada, Toshiyuki; Ngan, S. Y.; Powell, G.; Choong, Peter F M.

In: European Journal of Surgical Oncology, Vol. 28, No. 1, 02.2002, p. 75-79.

Research output: Contribution to journalArticle

Kunisada, Toshiyuki ; Ngan, S. Y. ; Powell, G. ; Choong, Peter F M. / Wound complications following pre-operative radiotherapy for soft tissue sarcoma. In: European Journal of Surgical Oncology. 2002 ; Vol. 28, No. 1. pp. 75-79.
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