White spot lesion remineralization by sugar-free chewing gum containing bio-available calcium and fluoride

A double-blind randomized controlled trial

Miho Sugiura, Yuichi Kitasako, Alireza Sadr, Yasushi Shimada, Yasunori Sumi, Junji Tagami

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives To assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and fluoride on white spot lesion (WSL) remineralization in comparison with POs-Ca or placebo (control) chewing gums, in double- blind, randomized, controlled trial. Methods Thirty-seven healthy subjects, who had at least one WSL, with an ICDAS score of 2 or 1, were recruited for this study. The subjects were randomly divided into three groups (control, POs-Ca, POs-Ca + F) and chewed two slabs of each gum three times every day for 3 months. WSLs were assessed using ICDAS criteria and optical boundary depth (BD) by optical coherence tomography (OCT) system at a monthly recall. Data were analyzed by Wilcoxon rank-sum test and Wilcoxon signed rank test with Bonferroni corrections at 0.05 significance level. Results Visual score changes from ICDAS score 2 to score 1 over the course of the study were observed; control (30%), POs-Ca (48%) and POs-Ca + F (45%). Unlike the control gum, chewing POs-Ca and POs-Ca + F gums resulted in significant changes in the mean value of BD over the 3 months course of the study (p < 0.05). There was a significant difference in mean value of BD after first month between POs-Ca + F and control groups (p < 0.05). Conclusions This study highlighted the importance of calcium and fluoride ion bioavailability in the reinforcement of demineralized enamel lesions by chewing gums. Furthermore, adding fluoride to POs-Ca might speed up the remineralization progress on natural WSL.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalJournal of Dentistry
Volume54
DOIs
Publication statusPublished - 2016
Externally publishedYes

Fingerprint

Calcium Fluoride
Chewing Gum
Dental Caries
Oligosaccharides
Randomized Controlled Trials
Calcium
Nonparametric Statistics
Gingiva
Control Groups
Mastication
Optical Coherence Tomography
Dental Enamel
Fluorides
Biological Availability
Healthy Volunteers

Keywords

  • Chewing gum
  • Double-blind
  • Enamel
  • Randomized controlled trial
  • Remineralization
  • White spot

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

White spot lesion remineralization by sugar-free chewing gum containing bio-available calcium and fluoride : A double-blind randomized controlled trial. / Sugiura, Miho; Kitasako, Yuichi; Sadr, Alireza; Shimada, Yasushi; Sumi, Yasunori; Tagami, Junji.

In: Journal of Dentistry, Vol. 54, 2016, p. 86-91.

Research output: Contribution to journalArticle

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abstract = "Objectives To assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and fluoride on white spot lesion (WSL) remineralization in comparison with POs-Ca or placebo (control) chewing gums, in double- blind, randomized, controlled trial. Methods Thirty-seven healthy subjects, who had at least one WSL, with an ICDAS score of 2 or 1, were recruited for this study. The subjects were randomly divided into three groups (control, POs-Ca, POs-Ca + F) and chewed two slabs of each gum three times every day for 3 months. WSLs were assessed using ICDAS criteria and optical boundary depth (BD) by optical coherence tomography (OCT) system at a monthly recall. Data were analyzed by Wilcoxon rank-sum test and Wilcoxon signed rank test with Bonferroni corrections at 0.05 significance level. Results Visual score changes from ICDAS score 2 to score 1 over the course of the study were observed; control (30{\%}), POs-Ca (48{\%}) and POs-Ca + F (45{\%}). Unlike the control gum, chewing POs-Ca and POs-Ca + F gums resulted in significant changes in the mean value of BD over the 3 months course of the study (p < 0.05). There was a significant difference in mean value of BD after first month between POs-Ca + F and control groups (p < 0.05). Conclusions This study highlighted the importance of calcium and fluoride ion bioavailability in the reinforcement of demineralized enamel lesions by chewing gums. Furthermore, adding fluoride to POs-Ca might speed up the remineralization progress on natural WSL.",
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AB - Objectives To assess the effect of chewing gum containing phosphoryl oligosaccharides of calcium (POs-Ca) and fluoride on white spot lesion (WSL) remineralization in comparison with POs-Ca or placebo (control) chewing gums, in double- blind, randomized, controlled trial. Methods Thirty-seven healthy subjects, who had at least one WSL, with an ICDAS score of 2 or 1, were recruited for this study. The subjects were randomly divided into three groups (control, POs-Ca, POs-Ca + F) and chewed two slabs of each gum three times every day for 3 months. WSLs were assessed using ICDAS criteria and optical boundary depth (BD) by optical coherence tomography (OCT) system at a monthly recall. Data were analyzed by Wilcoxon rank-sum test and Wilcoxon signed rank test with Bonferroni corrections at 0.05 significance level. Results Visual score changes from ICDAS score 2 to score 1 over the course of the study were observed; control (30%), POs-Ca (48%) and POs-Ca + F (45%). Unlike the control gum, chewing POs-Ca and POs-Ca + F gums resulted in significant changes in the mean value of BD over the 3 months course of the study (p < 0.05). There was a significant difference in mean value of BD after first month between POs-Ca + F and control groups (p < 0.05). Conclusions This study highlighted the importance of calcium and fluoride ion bioavailability in the reinforcement of demineralized enamel lesions by chewing gums. Furthermore, adding fluoride to POs-Ca might speed up the remineralization progress on natural WSL.

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