What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?

Masahiro Miyajima, Atsushi Watanabe, Toshihiko Sato, Satoshi Teramukai, Masahito Ebina, Kazuma Kishi, Yukihiko Sugiyama, Haruhiko Kondo, Satoru Kobayashi, Yutaka Takahashi, Hiroyuki Ito, Ryoji Yamamoto, Shigeki Sawada, Hideki Fujimori, Kazunori Okabe, Jun Arikura, Yasushi Shintani, Hiroshige Nakamura, Shinichi Toyooka, Tohru Hasumi & 9 others Takehiro Watanabe, Yoshinobu Hata, Hisashi Iwata, Minoru Aoki, Kazuhito Funai, Shuhei Inoue, Osamu Kawashima, Tomohiko Iida, Hiroshi Date

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purposes: Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. Methods: We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. Results: A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILD patients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. Conclusions: This study revealed eight risk factors for fatal AEIP.

Original languageEnglish
Pages (from-to)404-415
Number of pages12
JournalSurgery Today
Volume48
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Interstitial Lung Diseases
Lung Neoplasms
Survival
Emphysema
Multivariate Analysis
Idiopathic Pulmonary Fibrosis
Vital Capacity
Non-Small Cell Lung Carcinoma
Cause of Death
Japan
Steroids
Regression Analysis
Radiation

Keywords

  • Acute exacerbation of interstitial pneumonia
  • Idiopathic interstitial pneumonia
  • Neoadjuvant chemotherapy
  • Primary lung cancer
  • Sialylated carbohydrate antigen KL-6

ASJC Scopus subject areas

  • Surgery

Cite this

What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection? / Miyajima, Masahiro; Watanabe, Atsushi; Sato, Toshihiko; Teramukai, Satoshi; Ebina, Masahito; Kishi, Kazuma; Sugiyama, Yukihiko; Kondo, Haruhiko; Kobayashi, Satoru; Takahashi, Yutaka; Ito, Hiroyuki; Yamamoto, Ryoji; Sawada, Shigeki; Fujimori, Hideki; Okabe, Kazunori; Arikura, Jun; Shintani, Yasushi; Nakamura, Hiroshige; Toyooka, Shinichi; Hasumi, Tohru; Watanabe, Takehiro; Hata, Yoshinobu; Iwata, Hisashi; Aoki, Minoru; Funai, Kazuhito; Inoue, Shuhei; Kawashima, Osamu; Iida, Tomohiko; Date, Hiroshi.

In: Surgery Today, Vol. 48, No. 4, 01.04.2018, p. 404-415.

Research output: Contribution to journalArticle

Miyajima, M, Watanabe, A, Sato, T, Teramukai, S, Ebina, M, Kishi, K, Sugiyama, Y, Kondo, H, Kobayashi, S, Takahashi, Y, Ito, H, Yamamoto, R, Sawada, S, Fujimori, H, Okabe, K, Arikura, J, Shintani, Y, Nakamura, H, Toyooka, S, Hasumi, T, Watanabe, T, Hata, Y, Iwata, H, Aoki, M, Funai, K, Inoue, S, Kawashima, O, Iida, T & Date, H 2018, 'What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?', Surgery Today, vol. 48, no. 4, pp. 404-415. https://doi.org/10.1007/s00595-017-1605-8
Miyajima, Masahiro ; Watanabe, Atsushi ; Sato, Toshihiko ; Teramukai, Satoshi ; Ebina, Masahito ; Kishi, Kazuma ; Sugiyama, Yukihiko ; Kondo, Haruhiko ; Kobayashi, Satoru ; Takahashi, Yutaka ; Ito, Hiroyuki ; Yamamoto, Ryoji ; Sawada, Shigeki ; Fujimori, Hideki ; Okabe, Kazunori ; Arikura, Jun ; Shintani, Yasushi ; Nakamura, Hiroshige ; Toyooka, Shinichi ; Hasumi, Tohru ; Watanabe, Takehiro ; Hata, Yoshinobu ; Iwata, Hisashi ; Aoki, Minoru ; Funai, Kazuhito ; Inoue, Shuhei ; Kawashima, Osamu ; Iida, Tomohiko ; Date, Hiroshi. / What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?. In: Surgery Today. 2018 ; Vol. 48, No. 4. pp. 404-415.
@article{88ca1c196104496088fd75e37eb582a8,
title = "What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?",
abstract = "Purposes: Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. Methods: We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3{\%}) patients with a mortality rate of 43.9{\%} (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. Results: A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILD patients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. Conclusions: This study revealed eight risk factors for fatal AEIP.",
keywords = "Acute exacerbation of interstitial pneumonia, Idiopathic interstitial pneumonia, Neoadjuvant chemotherapy, Primary lung cancer, Sialylated carbohydrate antigen KL-6",
author = "Masahiro Miyajima and Atsushi Watanabe and Toshihiko Sato and Satoshi Teramukai and Masahito Ebina and Kazuma Kishi and Yukihiko Sugiyama and Haruhiko Kondo and Satoru Kobayashi and Yutaka Takahashi and Hiroyuki Ito and Ryoji Yamamoto and Shigeki Sawada and Hideki Fujimori and Kazunori Okabe and Jun Arikura and Yasushi Shintani and Hiroshige Nakamura and Shinichi Toyooka and Tohru Hasumi and Takehiro Watanabe and Yoshinobu Hata and Hisashi Iwata and Minoru Aoki and Kazuhito Funai and Shuhei Inoue and Osamu Kawashima and Tomohiko Iida and Hiroshi Date",
year = "2018",
month = "4",
day = "1",
doi = "10.1007/s00595-017-1605-8",
language = "English",
volume = "48",
pages = "404--415",
journal = "Japanese Journal of Surgery",
issn = "0941-1291",
publisher = "Springer Japan",
number = "4",

}

TY - JOUR

T1 - What factors determine the survival of patients with an acute exacerbation of interstitial lung disease after lung cancer resection?

AU - Miyajima, Masahiro

AU - Watanabe, Atsushi

AU - Sato, Toshihiko

AU - Teramukai, Satoshi

AU - Ebina, Masahito

AU - Kishi, Kazuma

AU - Sugiyama, Yukihiko

AU - Kondo, Haruhiko

AU - Kobayashi, Satoru

AU - Takahashi, Yutaka

AU - Ito, Hiroyuki

AU - Yamamoto, Ryoji

AU - Sawada, Shigeki

AU - Fujimori, Hideki

AU - Okabe, Kazunori

AU - Arikura, Jun

AU - Shintani, Yasushi

AU - Nakamura, Hiroshige

AU - Toyooka, Shinichi

AU - Hasumi, Tohru

AU - Watanabe, Takehiro

AU - Hata, Yoshinobu

AU - Iwata, Hisashi

AU - Aoki, Minoru

AU - Funai, Kazuhito

AU - Inoue, Shuhei

AU - Kawashima, Osamu

AU - Iida, Tomohiko

AU - Date, Hiroshi

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Purposes: Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. Methods: We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. Results: A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILD patients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. Conclusions: This study revealed eight risk factors for fatal AEIP.

AB - Purposes: Acute exacerbation of interstitial pneumonia (AEIP) is a leading cause of death after lung cancer resection in patients with interstitial lung disease. Methods: We retrospectively analyzed 1763 patients with non-small cell lung cancer with a clinical diagnosis of interstitial lung disease (ILD) who underwent lung cancer resection between 2000 and 2009 at 61 hospitals in Japan. AEIP occurred in 164 of 1763 (9.3%) patients with a mortality rate of 43.9% (72/164). Univariate and multivariate analyses were carried out to identify possible risk factors of fatal AEIP. We then analyzed the 164 patients who developed postoperative AEIP and identified the preoperative and postoperative risk factors. Results: A multivariate regression analysis identified that the sex, percent vital capacity, neoadjuvant radiation, preoperative history of AEIP, preoperative use of steroids, usual interstitial pneumonia pattern on CT, and surgical procedures were independent preoperative risk factors for death due to AEIP. ILD patients with emphysema somehow showed a lower risk of fatal AEIP than those without emphysema in this study. Conclusions: This study revealed eight risk factors for fatal AEIP.

KW - Acute exacerbation of interstitial pneumonia

KW - Idiopathic interstitial pneumonia

KW - Neoadjuvant chemotherapy

KW - Primary lung cancer

KW - Sialylated carbohydrate antigen KL-6

UR - http://www.scopus.com/inward/record.url?scp=85033448438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033448438&partnerID=8YFLogxK

U2 - 10.1007/s00595-017-1605-8

DO - 10.1007/s00595-017-1605-8

M3 - Article

VL - 48

SP - 404

EP - 415

JO - Japanese Journal of Surgery

JF - Japanese Journal of Surgery

SN - 0941-1291

IS - 4

ER -