What factors are associated with high plasma B-type natriuretic peptide levels in a general Japanese population?

H. Kanda, Y. Kita, T. Okamura, T. Kadowaki, Y. Yoshida, Y. Nakamura, H. Ueshima

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

There are few community-based epidemiologic studies that have dealt with risk factors for heart failure in non-Western populations. It has been reported that the measurement of plasma B-type natriuretic peptide (BNP) is useful for detecting patients with asymptomatic heart failure. To clarify the determinants of high plasma BNP level, the association of BNP with cardiovascular risk factors in community dwelling residents was examined. The plasma BNP levels were measured in 686 residents aged 35-69 years who received annual health check-up. The relationship of BNP to blood pressure, blood haemoglobin, serum cholesterol (total and high-density lipoprotein cholesterol), plasma glucose, electrocardiographic (ECG) findings, urinary salt excretion, and lifestyle factors (smoking and alcohol consumption) were cross-sectionally analysed. The plasma BNP geometric mean was 13.7 pg/ml. Both linear and logistic regression analyses indicated that the plasma BNP levels were positively associated with age, urinary salt excretion, higher blood pressure, high R-wave voltage in the 12-lead ECG (Minnesota Code 3-1 or 3-3), and female gender. Plasma BNP levels were inversely associated with blood haemoglobin levels. Gender-specific analysis showed similar results. However, plasma BNP did not correlate with other cardiovascular risk factors such as serum lipids.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalJournal of Human Hypertension
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 1 2005
Externally publishedYes

Fingerprint

Brain Natriuretic Peptide
Population
Hemoglobins
Heart Failure
Salts
Independent Living
Serum
Alcohol Drinking
HDL Cholesterol
Life Style
Epidemiologic Studies
Linear Models
Logistic Models
Smoking
Cholesterol
Regression Analysis
Blood Pressure
Hypertension
Lipids
Glucose

Keywords

  • B-type natriuretic peptide
  • General Population
  • High R-wave voltage in the 12-lead ECG
  • Risk factors
  • Urinary salt excretion

ASJC Scopus subject areas

  • Internal Medicine

Cite this

What factors are associated with high plasma B-type natriuretic peptide levels in a general Japanese population? / Kanda, H.; Kita, Y.; Okamura, T.; Kadowaki, T.; Yoshida, Y.; Nakamura, Y.; Ueshima, H.

In: Journal of Human Hypertension, Vol. 19, No. 2, 01.02.2005, p. 165-172.

Research output: Contribution to journalArticle

Kanda, H. ; Kita, Y. ; Okamura, T. ; Kadowaki, T. ; Yoshida, Y. ; Nakamura, Y. ; Ueshima, H. / What factors are associated with high plasma B-type natriuretic peptide levels in a general Japanese population?. In: Journal of Human Hypertension. 2005 ; Vol. 19, No. 2. pp. 165-172.
@article{dcd9937a106f4841a81c3b9775807a37,
title = "What factors are associated with high plasma B-type natriuretic peptide levels in a general Japanese population?",
abstract = "There are few community-based epidemiologic studies that have dealt with risk factors for heart failure in non-Western populations. It has been reported that the measurement of plasma B-type natriuretic peptide (BNP) is useful for detecting patients with asymptomatic heart failure. To clarify the determinants of high plasma BNP level, the association of BNP with cardiovascular risk factors in community dwelling residents was examined. The plasma BNP levels were measured in 686 residents aged 35-69 years who received annual health check-up. The relationship of BNP to blood pressure, blood haemoglobin, serum cholesterol (total and high-density lipoprotein cholesterol), plasma glucose, electrocardiographic (ECG) findings, urinary salt excretion, and lifestyle factors (smoking and alcohol consumption) were cross-sectionally analysed. The plasma BNP geometric mean was 13.7 pg/ml. Both linear and logistic regression analyses indicated that the plasma BNP levels were positively associated with age, urinary salt excretion, higher blood pressure, high R-wave voltage in the 12-lead ECG (Minnesota Code 3-1 or 3-3), and female gender. Plasma BNP levels were inversely associated with blood haemoglobin levels. Gender-specific analysis showed similar results. However, plasma BNP did not correlate with other cardiovascular risk factors such as serum lipids.",
keywords = "B-type natriuretic peptide, General Population, High R-wave voltage in the 12-lead ECG, Risk factors, Urinary salt excretion",
author = "H. Kanda and Y. Kita and T. Okamura and T. Kadowaki and Y. Yoshida and Y. Nakamura and H. Ueshima",
year = "2005",
month = "2",
day = "1",
doi = "10.1038/sj.jhh.1001792",
language = "English",
volume = "19",
pages = "165--172",
journal = "Journal of Human Hypertension",
issn = "0950-9240",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - What factors are associated with high plasma B-type natriuretic peptide levels in a general Japanese population?

AU - Kanda, H.

AU - Kita, Y.

AU - Okamura, T.

AU - Kadowaki, T.

AU - Yoshida, Y.

AU - Nakamura, Y.

AU - Ueshima, H.

PY - 2005/2/1

Y1 - 2005/2/1

N2 - There are few community-based epidemiologic studies that have dealt with risk factors for heart failure in non-Western populations. It has been reported that the measurement of plasma B-type natriuretic peptide (BNP) is useful for detecting patients with asymptomatic heart failure. To clarify the determinants of high plasma BNP level, the association of BNP with cardiovascular risk factors in community dwelling residents was examined. The plasma BNP levels were measured in 686 residents aged 35-69 years who received annual health check-up. The relationship of BNP to blood pressure, blood haemoglobin, serum cholesterol (total and high-density lipoprotein cholesterol), plasma glucose, electrocardiographic (ECG) findings, urinary salt excretion, and lifestyle factors (smoking and alcohol consumption) were cross-sectionally analysed. The plasma BNP geometric mean was 13.7 pg/ml. Both linear and logistic regression analyses indicated that the plasma BNP levels were positively associated with age, urinary salt excretion, higher blood pressure, high R-wave voltage in the 12-lead ECG (Minnesota Code 3-1 or 3-3), and female gender. Plasma BNP levels were inversely associated with blood haemoglobin levels. Gender-specific analysis showed similar results. However, plasma BNP did not correlate with other cardiovascular risk factors such as serum lipids.

AB - There are few community-based epidemiologic studies that have dealt with risk factors for heart failure in non-Western populations. It has been reported that the measurement of plasma B-type natriuretic peptide (BNP) is useful for detecting patients with asymptomatic heart failure. To clarify the determinants of high plasma BNP level, the association of BNP with cardiovascular risk factors in community dwelling residents was examined. The plasma BNP levels were measured in 686 residents aged 35-69 years who received annual health check-up. The relationship of BNP to blood pressure, blood haemoglobin, serum cholesterol (total and high-density lipoprotein cholesterol), plasma glucose, electrocardiographic (ECG) findings, urinary salt excretion, and lifestyle factors (smoking and alcohol consumption) were cross-sectionally analysed. The plasma BNP geometric mean was 13.7 pg/ml. Both linear and logistic regression analyses indicated that the plasma BNP levels were positively associated with age, urinary salt excretion, higher blood pressure, high R-wave voltage in the 12-lead ECG (Minnesota Code 3-1 or 3-3), and female gender. Plasma BNP levels were inversely associated with blood haemoglobin levels. Gender-specific analysis showed similar results. However, plasma BNP did not correlate with other cardiovascular risk factors such as serum lipids.

KW - B-type natriuretic peptide

KW - General Population

KW - High R-wave voltage in the 12-lead ECG

KW - Risk factors

KW - Urinary salt excretion

UR - http://www.scopus.com/inward/record.url?scp=13544254592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13544254592&partnerID=8YFLogxK

U2 - 10.1038/sj.jhh.1001792

DO - 10.1038/sj.jhh.1001792

M3 - Article

C2 - 15496965

AN - SCOPUS:13544254592

VL - 19

SP - 165

EP - 172

JO - Journal of Human Hypertension

JF - Journal of Human Hypertension

SN - 0950-9240

IS - 2

ER -