Water sorption and glass transition behaviors of freeze-dried sucrose-dextran mixtures

Koreyoshi Imamura, Atsushi Fukushima, Keisuke Sakaura, Takuo Sugita, Takaharu Sakiyama, Kazuhiro Nakanishi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The water sorption and glass transition behaviors of freeze-dried disaccharide-polysaccharide mixtures at various contents were investigated at relative humidities (RHs) of 0, 11, 23, and 33%. Sucrose and three types of dextrans, which differ in molecular weight, were used as model di- and polysaccharides, respectively. The relationship between the dextran and water contents of the sucrose-dextran mixture at different constant RHs indicated that a mixture of sucrose and dextran was lower than that calculated by the Lang and Steinberg mass balance equation. In the RH range of 0-23%, the glass transition temperature, Tg, increased to a considerable extent when the dextran content was equal to or higher than 50%, while the increase in Tg at dextran contents lower than 50% was small. A marked increase in Tg was observed at RH 33% for dextran contents of 0-25% as well as in the range above 50%. This suggests that the physical stability of the highly hydrated amorphous disaccharide is effectively strengthened by the addition of a small amount of polysaccharide. These tendencies were similar for the three dextrans of different molecular weights. Furthermore, it was demonstrated that the addition of a small amount of dextran is quite effective in preventing the collapse of amorphous sugar during freeze drying.

Original languageEnglish
Pages (from-to)2175-2181
Number of pages7
JournalJournal of Pharmaceutical Sciences
Volume91
Issue number10
DOIs
Publication statusPublished - Oct 2002

Fingerprint

Dextrans
Glass
Sucrose
Sorption
Glass transition
Water
Humidity
Disaccharides
Atmospheric humidity
Polysaccharides
Molecular Weight
Molecular weight
Freeze Drying
Transition Temperature
Sugars
Water content
Drying

Keywords

  • Disaccaride-polysacharide mixtures
  • Freeze drying
  • Glass transition
  • Water sorption

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Water sorption and glass transition behaviors of freeze-dried sucrose-dextran mixtures. / Imamura, Koreyoshi; Fukushima, Atsushi; Sakaura, Keisuke; Sugita, Takuo; Sakiyama, Takaharu; Nakanishi, Kazuhiro.

In: Journal of Pharmaceutical Sciences, Vol. 91, No. 10, 10.2002, p. 2175-2181.

Research output: Contribution to journalArticle

Imamura, K, Fukushima, A, Sakaura, K, Sugita, T, Sakiyama, T & Nakanishi, K 2002, 'Water sorption and glass transition behaviors of freeze-dried sucrose-dextran mixtures', Journal of Pharmaceutical Sciences, vol. 91, no. 10, pp. 2175-2181. https://doi.org/10.1002/jps.10218
Imamura, Koreyoshi ; Fukushima, Atsushi ; Sakaura, Keisuke ; Sugita, Takuo ; Sakiyama, Takaharu ; Nakanishi, Kazuhiro. / Water sorption and glass transition behaviors of freeze-dried sucrose-dextran mixtures. In: Journal of Pharmaceutical Sciences. 2002 ; Vol. 91, No. 10. pp. 2175-2181.
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