Wakayama symposium: Epithelial-mesenchymal interactions in eyelid development

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Various congenital anomalies of the eyelids can result from abnormal tissue proliferation, fusion, and reopening of the eyelids. Therefore, it is important to study the molecular mechanisms underlying eyelid development, focusing on cell behaviors. Mammalian eyelid development occurs in four steps: specification, growth, epithelial fusion, and reopening. Epithelial-mesenchymal interactions are fundamental processes during eyelid formation, and epithelial factors functioning within the eyelid epithelium are also critical. Studies with mutant and genetically modified mice have revealed that various signaling pathways and transcriptional factors are involved in mouse eyelid development. In this review, eyelid morphogenetic factors or pathways are described, as revealed by their mutant phenotype, eye-open at birth (EOB). These include FGFR2b- FGF10, EGFR-ERK, MEKK-JNK, BMP, Shh, Wnt, GPR48, Jun, Forkhead, and Grainyhead.

Original languageEnglish
Pages (from-to)212-216
Number of pages5
JournalOcular Surface
Volume10
Issue number4
DOIs
Publication statusPublished - 2012

Fingerprint

Eyelids
Receptor, Fibroblast Growth Factor, Type 2
MAP Kinase Kinase Kinases
Epithelium
Parturition
Phenotype
Growth

Keywords

  • Epithelial-mesenchymal interactions
  • Eyelid development
  • FGF10
  • Knockout
  • Mutant mouse
  • Periderm

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Wakayama symposium : Epithelial-mesenchymal interactions in eyelid development. / Ohuchi, Hideyo.

In: Ocular Surface, Vol. 10, No. 4, 2012, p. 212-216.

Research output: Contribution to journalReview article

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