VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion

H. Ichikawa, T. Sugimoto

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)


Immunohistochemistry for VR1, a nociceptive transducer for vanilloid compounds, protons and heat (>43°C), was performed on the rat trigeminal ganglion (TG). The immunoreactivity (IR) was detected in 20% of TG cells and these neurons were mostly small- to medium-sized (mean±S.D. 427±189 μm2). Twenty-six percent of the TG neurons retrogradely labeled from the facial skin exhibited VR1-IR, while the IR was detected in only 8% of those labeled from the tooth pulp. Co-expression of VR1 was common among the calcitonin gene-related peptide-immunoreactive cutaneous neurons (63%) but not among the similar tooth pulp neurons (20%). The present study indicates that primary nociceptive neurons which respond to vanilloid compounds, protons and heat are abundant in the facial skin but not in the tooth pulp.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalBrain Research
Issue number1
Publication statusPublished - Jan 26 2001


  • Calcitonin gene-related peptide
  • Immunohistochemistry
  • Skin
  • Tooth pulp
  • Trigeminal ganglion
  • VR1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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