Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle

Atsuko Niwa, Masahiro Nishibori, Shinichi Hamasaki, Takuro Kobori, Keyue Liu, Hidenori Wake, Shuji Mori, Tadashi Yoshino, Hideo Takahashi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.

Original languageEnglish
JournalBrain Structure and Function
DOIs
Publication statusAccepted/In press - Jan 30 2015

Fingerprint

Third Ventricle
Neurogenesis
Ependymoglial Cells
Hypothalamus
Stroke
Cell Proliferation
Neurochemistry
Recovery of Function
Fibroblast Growth Factor 2
Inbred SHR Rats
Running
Cerebrospinal Fluid
Cell Differentiation
Rodentia
Stem Cells
Neurons
Brain

Keywords

  • Hypothalamus
  • Neurogenesis
  • Stroke
  • Stroke-prone spontaneously hypertensive rats
  • Tanycytes
  • Voluntary exercise

ASJC Scopus subject areas

  • Neuroscience(all)
  • Anatomy
  • Histology

Cite this

Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle. / Niwa, Atsuko; Nishibori, Masahiro; Hamasaki, Shinichi; Kobori, Takuro; Liu, Keyue; Wake, Hidenori; Mori, Shuji; Yoshino, Tadashi; Takahashi, Hideo.

In: Brain Structure and Function, 30.01.2015.

Research output: Contribution to journalArticle

@article{45a27cedc8fb406cbdda82a1d273f801,
title = "Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle",
abstract = "In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.",
keywords = "Hypothalamus, Neurogenesis, Stroke, Stroke-prone spontaneously hypertensive rats, Tanycytes, Voluntary exercise",
author = "Atsuko Niwa and Masahiro Nishibori and Shinichi Hamasaki and Takuro Kobori and Keyue Liu and Hidenori Wake and Shuji Mori and Tadashi Yoshino and Hideo Takahashi",
year = "2015",
month = "1",
day = "30",
doi = "10.1007/s00429-015-0995-x",
language = "English",
journal = "Anatomy and Embryology",
issn = "0177-5154",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle

AU - Niwa, Atsuko

AU - Nishibori, Masahiro

AU - Hamasaki, Shinichi

AU - Kobori, Takuro

AU - Liu, Keyue

AU - Wake, Hidenori

AU - Mori, Shuji

AU - Yoshino, Tadashi

AU - Takahashi, Hideo

PY - 2015/1/30

Y1 - 2015/1/30

N2 - In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.

AB - In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.

KW - Hypothalamus

KW - Neurogenesis

KW - Stroke

KW - Stroke-prone spontaneously hypertensive rats

KW - Tanycytes

KW - Voluntary exercise

UR - http://www.scopus.com/inward/record.url?scp=84922363198&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922363198&partnerID=8YFLogxK

U2 - 10.1007/s00429-015-0995-x

DO - 10.1007/s00429-015-0995-x

M3 - Article

C2 - 25633473

AN - SCOPUS:84922363198

JO - Anatomy and Embryology

JF - Anatomy and Embryology

SN - 0177-5154

ER -