Abstract
In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.
| Original language | English |
|---|---|
| Journal | Brain Structure and Function |
| DOIs | |
| Publication status | Accepted/In press - Jan 30 2015 |
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Keywords
- Hypothalamus
- Neurogenesis
- Stroke
- Stroke-prone spontaneously hypertensive rats
- Tanycytes
- Voluntary exercise
ASJC Scopus subject areas
- Neuroscience(all)
- Anatomy
- Histology
Cite this
Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle. / Niwa, Atsuko; Nishibori, Masahiro; Hamasaki, Shinichi; Kobori, Takuro; Liu, Keyue; Wake, Hidenori; Mori, Shuji; Yoshino, Tadashi; Takahashi, Hideo.
In: Brain Structure and Function, 30.01.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Voluntary exercise induces neurogenesis in the hypothalamus and ependymal lining of the third ventricle
AU - Niwa, Atsuko
AU - Nishibori, Masahiro
AU - Hamasaki, Shinichi
AU - Kobori, Takuro
AU - Liu, Keyue
AU - Wake, Hidenori
AU - Mori, Shuji
AU - Yoshino, Tadashi
AU - Takahashi, Hideo
PY - 2015/1/30
Y1 - 2015/1/30
N2 - In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.
AB - In the adult hypothalamus and ependymal lining of the third ventricle, tanycytes function as multipotential progenitor cells that enable continuous neurogenesis, suggesting that tanycytes may be able to mediate the restoration of homeostatic function after stroke. Voluntary wheel running has been shown to alter neurochemistry and neuronal function and to increase neurogenesis in rodents. In the present study, we found that voluntary exercise improved the survival rate and energy balance of stroke-prone spontaneously hypertensive rats (SHRSP/Kpo). We also investigated the effect of exercise on the proliferation and differentiation of hypothalamic cells using immunoreactivity for tanycytes and neural markers. The proliferation of elongated cells, which may be the tanycytes, was enhanced in exercising SHRSP compared to sedentary rats before and after stroke. In addition, the proliferation of cells was correlated with the induction of fibroblast growth factor-2 in the subependymal cells of the third ventricle and in the cerebrospinal fluid. Some of the newborn cells of exercising SHRSP showed differentiation into mature neurons after stroke. Our results suggest that voluntary exercise correlates with hypothalamic neurogenesis, leading to recovery of homeostatic functions in the adult brain after stroke.
KW - Hypothalamus
KW - Neurogenesis
KW - Stroke
KW - Stroke-prone spontaneously hypertensive rats
KW - Tanycytes
KW - Voluntary exercise
UR - http://www.scopus.com/inward/record.url?scp=84922363198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84922363198&partnerID=8YFLogxK
U2 - 10.1007/s00429-015-0995-x
DO - 10.1007/s00429-015-0995-x
M3 - Article
C2 - 25633473
AN - SCOPUS:84922363198
JO - Anatomy and Embryology
JF - Anatomy and Embryology
SN - 0177-5154
ER -