Volatile anesthetics susceptibility in mice strains evaluated with two end points of anesthesia

J. Nogaya; S. Bekku; X. P. Liu; H. Komatsu; J. Ono; H. Nakao; M. Ueki; S. Yokono; K. Ogli

Volatile anesthetics susceptibility in mice strains evaluated with two end points of anesthesia

J. Nogaya, S. Bekku, X. P. Liu, H. Komatsu, J. Ono, H. Nakao, M. Ueki, S. Yokono, K. Ogli

Research output: Contribution to journal › Article › peer-review

Abstract

We determined the volatile anesthetics requirement for loss of righting reflex (LORR) and loss of tail flick response (LOTF) in two strains of mice. The two strains showed different susceptibility in LOTF for all three anesthetics, in LORR for two anesthetics except halothane. For enflurane and isoflurane, the susceptibility for LORR and LOTF were in revised order between the two strains. These results mean that halothane depresses the RR in different mechanism from that of isoflurane ahd enflurane, and the continuum of anesthesia is determined not only by the drug itself but also the neurophysiological situation of the action site.

Original language	English
Pages (from-to)	5-6
Number of pages	2
Journal	Anesthesia and Resuscitation
Volume	36
Issue number	1-2
Publication status	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Emergency Medicine
Anesthesiology and Pain Medicine

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title = "Volatile anesthetics susceptibility in mice strains evaluated with two end points of anesthesia",

abstract = "We determined the volatile anesthetics requirement for loss of righting reflex (LORR) and loss of tail flick response (LOTF) in two strains of mice. The two strains showed different susceptibility in LOTF for all three anesthetics, in LORR for two anesthetics except halothane. For enflurane and isoflurane, the susceptibility for LORR and LOTF were in revised order between the two strains. These results mean that halothane depresses the RR in different mechanism from that of isoflurane ahd enflurane, and the continuum of anesthesia is determined not only by the drug itself but also the neurophysiological situation of the action site.",

author = "J. Nogaya and S. Bekku and Liu, {X. P.} and H. Komatsu and J. Ono and H. Nakao and M. Ueki and S. Yokono and K. Ogli",

year = "2000",

language = "English",

volume = "36",

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T1 - Volatile anesthetics susceptibility in mice strains evaluated with two end points of anesthesia

AU - Nogaya, J.

AU - Bekku, S.

AU - Liu, X. P.

AU - Komatsu, H.

AU - Ono, J.

AU - Nakao, H.

AU - Ueki, M.

AU - Yokono, S.

AU - Ogli, K.

PY - 2000

Y1 - 2000

N2 - We determined the volatile anesthetics requirement for loss of righting reflex (LORR) and loss of tail flick response (LOTF) in two strains of mice. The two strains showed different susceptibility in LOTF for all three anesthetics, in LORR for two anesthetics except halothane. For enflurane and isoflurane, the susceptibility for LORR and LOTF were in revised order between the two strains. These results mean that halothane depresses the RR in different mechanism from that of isoflurane ahd enflurane, and the continuum of anesthesia is determined not only by the drug itself but also the neurophysiological situation of the action site.

AB - We determined the volatile anesthetics requirement for loss of righting reflex (LORR) and loss of tail flick response (LOTF) in two strains of mice. The two strains showed different susceptibility in LOTF for all three anesthetics, in LORR for two anesthetics except halothane. For enflurane and isoflurane, the susceptibility for LORR and LOTF were in revised order between the two strains. These results mean that halothane depresses the RR in different mechanism from that of isoflurane ahd enflurane, and the continuum of anesthesia is determined not only by the drug itself but also the neurophysiological situation of the action site.

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