Volatile anesthetics susceptibility in mice strains evaluated with two end points of anesthesia

J. Nogaya, S. Bekku, X. P. Liu, H. Komatsu, J. Ono, H. Nakao, M. Ueki, S. Yokono, K. Ogli

Research output: Contribution to journalArticlepeer-review

Abstract

We determined the volatile anesthetics requirement for loss of righting reflex (LORR) and loss of tail flick response (LOTF) in two strains of mice. The two strains showed different susceptibility in LOTF for all three anesthetics, in LORR for two anesthetics except halothane. For enflurane and isoflurane, the susceptibility for LORR and LOTF were in revised order between the two strains. These results mean that halothane depresses the RR in different mechanism from that of isoflurane ahd enflurane, and the continuum of anesthesia is determined not only by the drug itself but also the neurophysiological situation of the action site.

Original languageEnglish
Pages (from-to)5-6
Number of pages2
JournalAnesthesia and Resuscitation
Volume36
Issue number1-2
Publication statusPublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Emergency Medicine
  • Anesthesiology and Pain Medicine

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