We determined the volatile anesthetics requirement for loss of righting reflex (LORR) and loss of tail flick response (LOTF) in two strains of mice. The two strains showed different susceptibility in LOTF for all three anesthetics, in LORR for two anesthetics except halothane. For enflurane and isoflurane, the susceptibility for LORR and LOTF were in revised order between the two strains. These results mean that halothane depresses the RR in different mechanism from that of isoflurane ahd enflurane, and the continuum of anesthesia is determined not only by the drug itself but also the neurophysiological situation of the action site.
|Number of pages||2|
|Journal||Anesthesia and Resuscitation|
|Publication status||Published - 2000|
ASJC Scopus subject areas
- Emergency Medicine
- Anesthesiology and Pain Medicine