Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a

Takahiro Shiga; Yoshifumi Kimira; Hiroshi Mano; Tetsunori Kawata; Tadahiro Tadokoro; Tsukasa Suzuki; Yuji Yamamoto

doi:10.1080/09168451.2015.1095071

Vitamin B₁₂ deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a

Takahiro Shiga, Yoshifumi Kimira, Hiroshi Mano, Tetsunori Kawata, Tadahiro Tadokoro, Tsukasa Suzuki, Yuji Yamamoto

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Vitamin B₁₂ deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a Vitamin B₁₂ deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a Vitamin B₁₂ deficiency suggests that Vitamin B₁₂ plays an important role in Pi homeostasis.

Original language	English
Pages (from-to)	510-513
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	80
Issue number	3
DOIs	https://doi.org/10.1080/09168451.2015.1095071
Publication status	Published - 2016

Keywords

Bone disorder
Inorganic phosphorus
Napi2a

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

Access to Document

10.1080/09168451.2015.1095071

Cite this

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title = "Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a",

abstract = "Vitamin B12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a Vitamin B12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a Vitamin B12 deficiency suggests that Vitamin B12 plays an important role in Pi homeostasis.",

keywords = "Bone disorder, Inorganic phosphorus, Napi2a",

author = "Takahiro Shiga and Yoshifumi Kimira and Hiroshi Mano and Tetsunori Kawata and Tadahiro Tadokoro and Tsukasa Suzuki and Yuji Yamamoto",

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AU - Shiga, Takahiro

AU - Kimira, Yoshifumi

AU - Mano, Hiroshi

AU - Kawata, Tetsunori

AU - Tadokoro, Tadahiro

AU - Suzuki, Tsukasa

AU - Yamamoto, Yuji

PY - 2016

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AB - Vitamin B12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a Vitamin B12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a Vitamin B12 deficiency suggests that Vitamin B12 plays an important role in Pi homeostasis.

KW - Bone disorder

KW - Inorganic phosphorus

KW - Napi2a

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