Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a

Takahiro Shiga; Yoshifumi Kimira; Hiroshi Mano; Tetsunori Kawata; Tadahiro Tadokoro; Tsukasa Suzuki; Yuji Yamamoto

doi:10.1080/09168451.2015.1095071

Vitamin B₁₂ deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a

Takahiro Shiga, Yoshifumi Kimira, Hiroshi Mano, Tetsunori Kawata, Tadahiro Tadokoro, Tsukasa Suzuki, Yuji Yamamoto

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Vitamin B₁₂ deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a Vitamin B₁₂ deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a Vitamin B₁₂ deficiency suggests that Vitamin B₁₂ plays an important role in Pi homeostasis.

Original language	English
Pages (from-to)	510-513
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	80
Issue number	3
DOIs	https://doi.org/10.1080/09168451.2015.1095071
Publication status	Published - 2016

Keywords

Bone disorder
Inorganic phosphorus
Napi2a

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

Access to Document

10.1080/09168451.2015.1095071

Cite this

Vitamin B₁₂ deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a. / Shiga, Takahiro; Kimira, Yoshifumi; Mano, Hiroshi; Kawata, Tetsunori; Tadokoro, Tadahiro; Suzuki, Tsukasa; Yamamoto, Yuji.

In: Bioscience, Biotechnology and Biochemistry, Vol. 80, No. 3, 2016, p. 510-513.

Research output: Contribution to journal › Article › peer-review

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