Abstract
Vitamin B12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a Vitamin B12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a Vitamin B12 deficiency suggests that Vitamin B12 plays an important role in Pi homeostasis.
| Original language | English |
|---|---|
| Pages (from-to) | 510-513 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 80 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2016 |
Keywords
- Bone disorder
- Inorganic phosphorus
- Napi2a
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Biology
- Applied Microbiology and Biotechnology
- Analytical Chemistry
- Organic Chemistry
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Shiga, T., Kimira, Y., Mano, H., Kawata, T., Tadokoro, T., Suzuki, T., & Yamamoto, Y. (2016). Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a. Bioscience, Biotechnology and Biochemistry, 80(3), 510-513. https://doi.org/10.1080/09168451.2015.1095071