Vitamin B12 deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a

Takahiro Shiga, Yoshifumi Kimira, Hiroshi Mano, Tetsunori Kawata, Tadahiro Tadokoro, Tsukasa Suzuki, Yuji Yamamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vitamin B12 deficiency is a risk factor for bone disorders via mechanisms not fully understood. In this study, an increase in serum inorganic phosphorus (Pi) concentrations was associated with a Vitamin B12 deficiency. Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a Vitamin B12 deficiency suggests that Vitamin B12 plays an important role in Pi homeostasis.

Original languageEnglish
Pages (from-to)510-513
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume80
Issue number3
DOIs
Publication statusPublished - 2016

Keywords

  • Bone disorder
  • Inorganic phosphorus
  • Napi2a

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

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