Visible light-induced crosslinkable gelatin

Tae Il Son, Makoto Sakuragi, Sawa Takahashi, Sei Obuse, Jeonghwa Kang, Masako Fujishiro, Haruhiko Matsushita, Jiansheng Gong, Shigeru Shimizu, Yusuke Tajima, Yasuhiro Yoshida, Kazuomi Suzuki, Toshio Yamamoto, Mariko Nakamura, Yoshihiro Ito

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

A novel visible light-crosslinkable porcine gelatin was prepared for gelation and micropatterning. The preparation employed a photo-oxidation-induced crosslinking mechanism. First, furfuryl groups were incorporated into the gelatin. Second, the modified gelatin was mixed in water with Rose Bengal, which is a visible light sensitizer. Irradiation by visible light solidified the aqueous solution. In addition, when the solution was cast on a plate, dried and photo-irradiated in the presence of a photomask a micropattern was formed that matched the micropattern on the photomask. The gelatin-immobilized regions enhanced cell adhesion. It was also confirmed that the gelatin incorporating furfuryl and Rose Bengal have no significant toxicity. The photo-crosslinkable gelatin was employed as a direct pulp capping material in the dental field. Considering these results, this system could be useful as a new type of visible light-induced crosslinkable biosealant.

Original languageEnglish
Pages (from-to)4005-4010
Number of pages6
JournalActa Biomaterialia
Volume6
Issue number10
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Keywords

  • Biosealant
  • Direct pulp capping
  • Gelatin
  • Photo-crosslinking
  • Visible light

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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  • Cite this

    Son, T. I., Sakuragi, M., Takahashi, S., Obuse, S., Kang, J., Fujishiro, M., Matsushita, H., Gong, J., Shimizu, S., Tajima, Y., Yoshida, Y., Suzuki, K., Yamamoto, T., Nakamura, M., & Ito, Y. (2010). Visible light-induced crosslinkable gelatin. Acta Biomaterialia, 6(10), 4005-4010. https://doi.org/10.1016/j.actbio.2010.05.018