Vesicular nucleotide transport: A brief history and the vesicular nucleotide transporter as a target for drug development

Miki Hiasa, Natsuko Togawa, Yoshinori Moriyama

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Neurons and neuroendocrine cells store nucleotides in vesicles and release them upon stimulation, leading to intercellular purinergic signaling. The molecular machinery responsible for the vesicular storage of nucleotides was a long standing enigma, however, recently the transporter involving in the process was identified. This article summarizes the history of vesicular storage of nucleotides and the identification of the vesicular nucleotide transporter (VNUT) responsible for the process. The significance of VNUT as a drug target to control purinergic chemical transmission is also discussed.

Original languageEnglish
Pages (from-to)2745-2749
Number of pages5
JournalCurrent Pharmaceutical Design
Volume20
Issue number16
DOIs
Publication statusPublished - 2014

Keywords

  • ADP
  • ATP
  • Drug target
  • Purinergic chemical transmission
  • Secretory granules
  • Synaptic vesicles
  • Vesicular nucleotide transporter

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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