Vesicoureteral reflux in male and female neonates as detected by voiding ultrasonography

Masahiro Hiraoka, Chikahide Hori, Hirokazu Tsukahara, Kenkou Kasuga, Yoshinori Ishihara, Fumikazu Kotsuji, Mitsufumi Mayumi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background. Vesicoureteral reflux (VUR) is assumed to be congenital, and its early diagnosis is desired in order to prevent acquired renal damage. However, the incidence of VUR in neonates remains to be revealed. Methods. Two thousand newborn babies (1048 boys and 952 girls) underwent voiding ultrasonography (an ultrasound examination of urinary tract during provoked voiding). Those who showed transient renal pelvic dilation during voiding, who had small kidneys, or who subsequently developed urinary infection underwent voiding cystourethrography. Results. Transient renal pelvic dilation was observed in 16 babies (0.8%), including one boy with small kidneys. Among the rest of the babies, one boy had a small kidney, and nine babies subsequently developed urinary infection. Voiding cystourethrography revealed VUR in 24 ureters of 16 children (11 boys and 5 girls). Dimercaptosuccinate renoscintigraphy confirmed small kidneys, with generally reduced tracer uptake in a total of three boys, all having VUR. Voiding ultrasonography detected transient renal pelvic dilation in 17 (71%) of the 24 kidneys with VUR and, strikingly, 16 of the 17 (94%) kidneys with high- grade VUR (grade III or more). Conclusion. This study effectively detected VUR in 0.8% of the neonates (mostly of high grades and predominantly in males) and voiding ultrasonography showed a decided usefulness for the detection of VUR. The male preponderance of VUR in neonates was considered to be due to the occurrence of congenitally small kidneys, with reflux found exclusively in males and easier ultrasound detection of VUR in male neonates because the majority of diagnoses are reported to be high grades of VUR.

Original languageEnglish
Pages (from-to)1486-1490
Number of pages5
JournalKidney International
Volume55
Issue number4
DOIs
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Vesico-Ureteral Reflux
Ultrasonography
Newborn Infant
Kidney
Dilatation
Ureter
Infection
Urinary Tract
Early Diagnosis

Keywords

  • Cystourethrography
  • Renal damage in neonates
  • Small kidney
  • Ultrasound
  • Urinary tract infection

ASJC Scopus subject areas

  • Nephrology

Cite this

Vesicoureteral reflux in male and female neonates as detected by voiding ultrasonography. / Hiraoka, Masahiro; Hori, Chikahide; Tsukahara, Hirokazu; Kasuga, Kenkou; Ishihara, Yoshinori; Kotsuji, Fumikazu; Mayumi, Mitsufumi.

In: Kidney International, Vol. 55, No. 4, 1999, p. 1486-1490.

Research output: Contribution to journalArticle

Hiraoka, Masahiro ; Hori, Chikahide ; Tsukahara, Hirokazu ; Kasuga, Kenkou ; Ishihara, Yoshinori ; Kotsuji, Fumikazu ; Mayumi, Mitsufumi. / Vesicoureteral reflux in male and female neonates as detected by voiding ultrasonography. In: Kidney International. 1999 ; Vol. 55, No. 4. pp. 1486-1490.
@article{460b32a0c20d4bf7b9aaa05b5eb94db5,
title = "Vesicoureteral reflux in male and female neonates as detected by voiding ultrasonography",
abstract = "Background. Vesicoureteral reflux (VUR) is assumed to be congenital, and its early diagnosis is desired in order to prevent acquired renal damage. However, the incidence of VUR in neonates remains to be revealed. Methods. Two thousand newborn babies (1048 boys and 952 girls) underwent voiding ultrasonography (an ultrasound examination of urinary tract during provoked voiding). Those who showed transient renal pelvic dilation during voiding, who had small kidneys, or who subsequently developed urinary infection underwent voiding cystourethrography. Results. Transient renal pelvic dilation was observed in 16 babies (0.8{\%}), including one boy with small kidneys. Among the rest of the babies, one boy had a small kidney, and nine babies subsequently developed urinary infection. Voiding cystourethrography revealed VUR in 24 ureters of 16 children (11 boys and 5 girls). Dimercaptosuccinate renoscintigraphy confirmed small kidneys, with generally reduced tracer uptake in a total of three boys, all having VUR. Voiding ultrasonography detected transient renal pelvic dilation in 17 (71{\%}) of the 24 kidneys with VUR and, strikingly, 16 of the 17 (94{\%}) kidneys with high- grade VUR (grade III or more). Conclusion. This study effectively detected VUR in 0.8{\%} of the neonates (mostly of high grades and predominantly in males) and voiding ultrasonography showed a decided usefulness for the detection of VUR. The male preponderance of VUR in neonates was considered to be due to the occurrence of congenitally small kidneys, with reflux found exclusively in males and easier ultrasound detection of VUR in male neonates because the majority of diagnoses are reported to be high grades of VUR.",
keywords = "Cystourethrography, Renal damage in neonates, Small kidney, Ultrasound, Urinary tract infection",
author = "Masahiro Hiraoka and Chikahide Hori and Hirokazu Tsukahara and Kenkou Kasuga and Yoshinori Ishihara and Fumikazu Kotsuji and Mitsufumi Mayumi",
year = "1999",
doi = "10.1046/j.1523-1755.1999.00380.x",
language = "English",
volume = "55",
pages = "1486--1490",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Vesicoureteral reflux in male and female neonates as detected by voiding ultrasonography

AU - Hiraoka, Masahiro

AU - Hori, Chikahide

AU - Tsukahara, Hirokazu

AU - Kasuga, Kenkou

AU - Ishihara, Yoshinori

AU - Kotsuji, Fumikazu

AU - Mayumi, Mitsufumi

PY - 1999

Y1 - 1999

N2 - Background. Vesicoureteral reflux (VUR) is assumed to be congenital, and its early diagnosis is desired in order to prevent acquired renal damage. However, the incidence of VUR in neonates remains to be revealed. Methods. Two thousand newborn babies (1048 boys and 952 girls) underwent voiding ultrasonography (an ultrasound examination of urinary tract during provoked voiding). Those who showed transient renal pelvic dilation during voiding, who had small kidneys, or who subsequently developed urinary infection underwent voiding cystourethrography. Results. Transient renal pelvic dilation was observed in 16 babies (0.8%), including one boy with small kidneys. Among the rest of the babies, one boy had a small kidney, and nine babies subsequently developed urinary infection. Voiding cystourethrography revealed VUR in 24 ureters of 16 children (11 boys and 5 girls). Dimercaptosuccinate renoscintigraphy confirmed small kidneys, with generally reduced tracer uptake in a total of three boys, all having VUR. Voiding ultrasonography detected transient renal pelvic dilation in 17 (71%) of the 24 kidneys with VUR and, strikingly, 16 of the 17 (94%) kidneys with high- grade VUR (grade III or more). Conclusion. This study effectively detected VUR in 0.8% of the neonates (mostly of high grades and predominantly in males) and voiding ultrasonography showed a decided usefulness for the detection of VUR. The male preponderance of VUR in neonates was considered to be due to the occurrence of congenitally small kidneys, with reflux found exclusively in males and easier ultrasound detection of VUR in male neonates because the majority of diagnoses are reported to be high grades of VUR.

AB - Background. Vesicoureteral reflux (VUR) is assumed to be congenital, and its early diagnosis is desired in order to prevent acquired renal damage. However, the incidence of VUR in neonates remains to be revealed. Methods. Two thousand newborn babies (1048 boys and 952 girls) underwent voiding ultrasonography (an ultrasound examination of urinary tract during provoked voiding). Those who showed transient renal pelvic dilation during voiding, who had small kidneys, or who subsequently developed urinary infection underwent voiding cystourethrography. Results. Transient renal pelvic dilation was observed in 16 babies (0.8%), including one boy with small kidneys. Among the rest of the babies, one boy had a small kidney, and nine babies subsequently developed urinary infection. Voiding cystourethrography revealed VUR in 24 ureters of 16 children (11 boys and 5 girls). Dimercaptosuccinate renoscintigraphy confirmed small kidneys, with generally reduced tracer uptake in a total of three boys, all having VUR. Voiding ultrasonography detected transient renal pelvic dilation in 17 (71%) of the 24 kidneys with VUR and, strikingly, 16 of the 17 (94%) kidneys with high- grade VUR (grade III or more). Conclusion. This study effectively detected VUR in 0.8% of the neonates (mostly of high grades and predominantly in males) and voiding ultrasonography showed a decided usefulness for the detection of VUR. The male preponderance of VUR in neonates was considered to be due to the occurrence of congenitally small kidneys, with reflux found exclusively in males and easier ultrasound detection of VUR in male neonates because the majority of diagnoses are reported to be high grades of VUR.

KW - Cystourethrography

KW - Renal damage in neonates

KW - Small kidney

KW - Ultrasound

KW - Urinary tract infection

UR - http://www.scopus.com/inward/record.url?scp=0032920774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032920774&partnerID=8YFLogxK

U2 - 10.1046/j.1523-1755.1999.00380.x

DO - 10.1046/j.1523-1755.1999.00380.x

M3 - Article

VL - 55

SP - 1486

EP - 1490

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 4

ER -