Versatile and practical chiral shift reagent with hydrogen-bond donor/acceptor sites in a macrocyclic cavity

Tadashi Ema, Daisuke Tanida, Takashi Sakai

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Bifunctional macrocycle 1 with C2 symmetry was newly synthesized. NMR studies demonstrated that receptor 1 functions as a chiral shift reagent (solvating agent) that is highly effective for a wide range of chiral compounds having a carboxylic acid, oxazolidinone, lactone, alcohol, sulfoxide, sulfoximine, isocyanate, or epoxide functionality. Binding constants were determined to investigate the binding behavior of 1.

Original languageEnglish
Pages (from-to)3773-3775
Number of pages3
JournalOrganic Letters
Volume8
Issue number17
DOIs
Publication statusPublished - Aug 17 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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