Ventricular contractility in atrial fibrillation is predictable by mechanical restitution and potentiation

Shunsuke Suzuki, Junichi Araki, Terumasa Morita, Satoshi Mohri, Takeshi Mikane, Hiroki Yamaguchi, Shunji Sano, Tohru Ohe, Masahisa Hirakawa, Hiroyuki Suga

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We recently found that contractility (E(max)) of an individual irregularly arrhythmic beat in electrically induced atrial fibrillation (AF) is reasonably predictable from the ratio of the preceding beat interval (RR1) to the beat interval immediately preceding RR1 (RR2) in the canine left ventricle. Moreover, the monotonically increasing relation between E(max) and the RR1-to-RR2 ratio (RR1/RR2) passed through or by the mean arrhythmic beat E(max) as well as the regular beat E(max) at RR1/RR2 = 1. We hypothesized that this E(max)-RR1/RR2 relation during irregular arrhythmia could be attributed to the basic characteristics of the mechanical restitution and potentiation. To test this, we adopted a known comprehensive equation describing the force restitution and potentiation as a function of two preceding beat intervals and simulated contractilities of irregular arrhythmic beats with randomized beat intervals on a computer. The simulated E(max)-RR1/RR2 relation reasonably resembled the one that we recently observed experimentally, supporting our hypothesis. We therefore conclude that the primary mechanism underlying the varying contractilities of irregular beats in AF is mechanical restitution and potentiation.

Original languageEnglish
Article number7
Pages (from-to)1513
Number of pages1519
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume275
Issue number5
Publication statusPublished - Nov 1998

Fingerprint

Atrial Fibrillation
Heart Ventricles
Canidae
Cardiac Arrhythmias

Keywords

  • Arrhythmia
  • Calcium
  • Contractility
  • Interval-force relation
  • Irregular rhythm

ASJC Scopus subject areas

  • Physiology

Cite this

Suzuki, S., Araki, J., Morita, T., Mohri, S., Mikane, T., Yamaguchi, H., ... Suga, H. (1998). Ventricular contractility in atrial fibrillation is predictable by mechanical restitution and potentiation. American Journal of Physiology - Heart and Circulatory Physiology, 275(5), 1513. [7].

Ventricular contractility in atrial fibrillation is predictable by mechanical restitution and potentiation. / Suzuki, Shunsuke; Araki, Junichi; Morita, Terumasa; Mohri, Satoshi; Mikane, Takeshi; Yamaguchi, Hiroki; Sano, Shunji; Ohe, Tohru; Hirakawa, Masahisa; Suga, Hiroyuki.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 275, No. 5, 7, 11.1998, p. 1513.

Research output: Contribution to journalArticle

Suzuki, S, Araki, J, Morita, T, Mohri, S, Mikane, T, Yamaguchi, H, Sano, S, Ohe, T, Hirakawa, M & Suga, H 1998, 'Ventricular contractility in atrial fibrillation is predictable by mechanical restitution and potentiation', American Journal of Physiology - Heart and Circulatory Physiology, vol. 275, no. 5, 7, pp. 1513.
Suzuki, Shunsuke ; Araki, Junichi ; Morita, Terumasa ; Mohri, Satoshi ; Mikane, Takeshi ; Yamaguchi, Hiroki ; Sano, Shunji ; Ohe, Tohru ; Hirakawa, Masahisa ; Suga, Hiroyuki. / Ventricular contractility in atrial fibrillation is predictable by mechanical restitution and potentiation. In: American Journal of Physiology - Heart and Circulatory Physiology. 1998 ; Vol. 275, No. 5. pp. 1513.
@article{46d6e7611aab452680d09d6a6c34c482,
title = "Ventricular contractility in atrial fibrillation is predictable by mechanical restitution and potentiation",
abstract = "We recently found that contractility (E(max)) of an individual irregularly arrhythmic beat in electrically induced atrial fibrillation (AF) is reasonably predictable from the ratio of the preceding beat interval (RR1) to the beat interval immediately preceding RR1 (RR2) in the canine left ventricle. Moreover, the monotonically increasing relation between E(max) and the RR1-to-RR2 ratio (RR1/RR2) passed through or by the mean arrhythmic beat E(max) as well as the regular beat E(max) at RR1/RR2 = 1. We hypothesized that this E(max)-RR1/RR2 relation during irregular arrhythmia could be attributed to the basic characteristics of the mechanical restitution and potentiation. To test this, we adopted a known comprehensive equation describing the force restitution and potentiation as a function of two preceding beat intervals and simulated contractilities of irregular arrhythmic beats with randomized beat intervals on a computer. The simulated E(max)-RR1/RR2 relation reasonably resembled the one that we recently observed experimentally, supporting our hypothesis. We therefore conclude that the primary mechanism underlying the varying contractilities of irregular beats in AF is mechanical restitution and potentiation.",
keywords = "Arrhythmia, Calcium, Contractility, Interval-force relation, Irregular rhythm",
author = "Shunsuke Suzuki and Junichi Araki and Terumasa Morita and Satoshi Mohri and Takeshi Mikane and Hiroki Yamaguchi and Shunji Sano and Tohru Ohe and Masahisa Hirakawa and Hiroyuki Suga",
year = "1998",
month = "11",
language = "English",
volume = "275",
pages = "1513",
journal = "American Journal of Physiology",
issn = "0002-9513",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Ventricular contractility in atrial fibrillation is predictable by mechanical restitution and potentiation

AU - Suzuki, Shunsuke

AU - Araki, Junichi

AU - Morita, Terumasa

AU - Mohri, Satoshi

AU - Mikane, Takeshi

AU - Yamaguchi, Hiroki

AU - Sano, Shunji

AU - Ohe, Tohru

AU - Hirakawa, Masahisa

AU - Suga, Hiroyuki

PY - 1998/11

Y1 - 1998/11

N2 - We recently found that contractility (E(max)) of an individual irregularly arrhythmic beat in electrically induced atrial fibrillation (AF) is reasonably predictable from the ratio of the preceding beat interval (RR1) to the beat interval immediately preceding RR1 (RR2) in the canine left ventricle. Moreover, the monotonically increasing relation between E(max) and the RR1-to-RR2 ratio (RR1/RR2) passed through or by the mean arrhythmic beat E(max) as well as the regular beat E(max) at RR1/RR2 = 1. We hypothesized that this E(max)-RR1/RR2 relation during irregular arrhythmia could be attributed to the basic characteristics of the mechanical restitution and potentiation. To test this, we adopted a known comprehensive equation describing the force restitution and potentiation as a function of two preceding beat intervals and simulated contractilities of irregular arrhythmic beats with randomized beat intervals on a computer. The simulated E(max)-RR1/RR2 relation reasonably resembled the one that we recently observed experimentally, supporting our hypothesis. We therefore conclude that the primary mechanism underlying the varying contractilities of irregular beats in AF is mechanical restitution and potentiation.

AB - We recently found that contractility (E(max)) of an individual irregularly arrhythmic beat in electrically induced atrial fibrillation (AF) is reasonably predictable from the ratio of the preceding beat interval (RR1) to the beat interval immediately preceding RR1 (RR2) in the canine left ventricle. Moreover, the monotonically increasing relation between E(max) and the RR1-to-RR2 ratio (RR1/RR2) passed through or by the mean arrhythmic beat E(max) as well as the regular beat E(max) at RR1/RR2 = 1. We hypothesized that this E(max)-RR1/RR2 relation during irregular arrhythmia could be attributed to the basic characteristics of the mechanical restitution and potentiation. To test this, we adopted a known comprehensive equation describing the force restitution and potentiation as a function of two preceding beat intervals and simulated contractilities of irregular arrhythmic beats with randomized beat intervals on a computer. The simulated E(max)-RR1/RR2 relation reasonably resembled the one that we recently observed experimentally, supporting our hypothesis. We therefore conclude that the primary mechanism underlying the varying contractilities of irregular beats in AF is mechanical restitution and potentiation.

KW - Arrhythmia

KW - Calcium

KW - Contractility

KW - Interval-force relation

KW - Irregular rhythm

UR - http://www.scopus.com/inward/record.url?scp=33750727090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750727090&partnerID=8YFLogxK

M3 - Article

C2 - 9815055

AN - SCOPUS:33750727090

VL - 275

SP - 1513

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0002-9513

IS - 5

M1 - 7

ER -