Vaspin and insulin resistance

Research output: Contribution to journalArticle

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Abstract

We have identified the vaspin gene(serpina12), which is up-regulated in visceral white adipose tissues (WATs) of Otsuka Long-Evans Tokushima fatty (OLETF) rat, an animal model of abdominal obesity and type 2 diabetes. Vaspin mRNA was barely detectable at 6 weeks of age, but was abundantly and exclusively expressed in visceral WATs at 30 weeks of age, when OLETF rats reach their peak body weight. However, vaspin mRNA decreased with worsening of diabetes and body weight loss. Vaspin mRNA increased with administration of thiazolidinediones, i.e. pioglitazone. Administration of recombinant vaspin into high fat high sucrose (HFHS) chow-induced obese ICR mice improved glucose tolerance and insulin sensitivity. Vaspin may be the compensatory molecule in the pathogenesis of metabolic syndrome and vaspin recombinant protein or vaspin-mimicking agents such as vaspin analogues, antibodies or small molecule agents would link to drug discovery and development.

Original languageEnglish
Pages (from-to)705-711
Number of pages7
JournalRinsho byori. The Japanese journal of clinical pathology
Volume56
Issue number8
Publication statusPublished - Aug 2008

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Inbred OLETF Rats
Insulin Resistance
White Adipose Tissue
Intra-Abdominal Fat
pioglitazone
Messenger RNA
Body Weight
Thiazolidinediones
Obese Mice
Inbred ICR Mouse
Abdominal Obesity
Drug Discovery
Recombinant Proteins
Type 2 Diabetes Mellitus
Sucrose
Weight Loss
Animal Models
Fats
Glucose
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vaspin and insulin resistance. / Wada, Jun.

In: Rinsho byori. The Japanese journal of clinical pathology, Vol. 56, No. 8, 08.2008, p. 705-711.

Research output: Contribution to journalArticle

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