Vascular protection and restorative therapy in ischemic stroke

Toru Yamashita, Kentaro Deguchi, Shoko Nagotani, Koji Abe

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring cerebral blood flow in the acute phase of ischemic stroke but sometimes causing hemorrhagic transformation (HT); 2) stem cell therapy: the repair of disrupted neuronal networks with newly born neurons in the chronic phase of ischemic stroke. Firstly, we estimated the vascular protective effect of a free radical scavenger, edaravone, in the tPA-treated rat model of middle cerebral artery occlusion. Edaravone prevented dramatically decreased the hemorrhagic transformation and improved the neurologic score and survival rate of tPA-treated rats. Secondly, we attempted to restore brain tissue using a novel biomaterial, polydimethysiloxane- tetraethoxysilane (PDMS-TEOS) hybrid with or without vascular endothelial growth factor (VEGF), and we could show that implantation of a PDMS-TEOS scaffold with VEGF might be effective for treating old brain infarction or trauma. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.

Original languageEnglish
Pages (from-to)95-97
Number of pages3
JournalCell Transplantation
Volume20
Issue number1
DOIs
Publication statusPublished - 2011

Fingerprint

Blood Vessels
Tissue Plasminogen Activator
Stroke
Tissue
Vascular Endothelial Growth Factor A
Rats
Brain
Cerebrovascular Circulation
Brain Infarction
Free Radical Scavengers
Middle Cerebral Artery Infarction
Thrombolytic Therapy
Biocompatible Materials
Polymers
Therapeutics
Cell- and Tissue-Based Therapy
Stem cells
Free radicals
Biomaterials
Scaffolds

Keywords

  • Cerebral ischemia
  • Free radicals
  • Neural stem cells
  • Scaffold
  • Tissue plasminogen activator (tPA)

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation
  • Biomedical Engineering

Cite this

Vascular protection and restorative therapy in ischemic stroke. / Yamashita, Toru; Deguchi, Kentaro; Nagotani, Shoko; Abe, Koji.

In: Cell Transplantation, Vol. 20, No. 1, 2011, p. 95-97.

Research output: Contribution to journalArticle

Yamashita, Toru ; Deguchi, Kentaro ; Nagotani, Shoko ; Abe, Koji. / Vascular protection and restorative therapy in ischemic stroke. In: Cell Transplantation. 2011 ; Vol. 20, No. 1. pp. 95-97.
@article{9bf9db79c0e841528cf9b772ebc54d3d,
title = "Vascular protection and restorative therapy in ischemic stroke",
abstract = "Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring cerebral blood flow in the acute phase of ischemic stroke but sometimes causing hemorrhagic transformation (HT); 2) stem cell therapy: the repair of disrupted neuronal networks with newly born neurons in the chronic phase of ischemic stroke. Firstly, we estimated the vascular protective effect of a free radical scavenger, edaravone, in the tPA-treated rat model of middle cerebral artery occlusion. Edaravone prevented dramatically decreased the hemorrhagic transformation and improved the neurologic score and survival rate of tPA-treated rats. Secondly, we attempted to restore brain tissue using a novel biomaterial, polydimethysiloxane- tetraethoxysilane (PDMS-TEOS) hybrid with or without vascular endothelial growth factor (VEGF), and we could show that implantation of a PDMS-TEOS scaffold with VEGF might be effective for treating old brain infarction or trauma. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.",
keywords = "Cerebral ischemia, Free radicals, Neural stem cells, Scaffold, Tissue plasminogen activator (tPA)",
author = "Toru Yamashita and Kentaro Deguchi and Shoko Nagotani and Koji Abe",
year = "2011",
doi = "10.3727/096368910X532800",
language = "English",
volume = "20",
pages = "95--97",
journal = "Cell Transplantation",
issn = "0963-6897",
publisher = "Cognizant Communication Corporation",
number = "1",

}

TY - JOUR

T1 - Vascular protection and restorative therapy in ischemic stroke

AU - Yamashita, Toru

AU - Deguchi, Kentaro

AU - Nagotani, Shoko

AU - Abe, Koji

PY - 2011

Y1 - 2011

N2 - Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring cerebral blood flow in the acute phase of ischemic stroke but sometimes causing hemorrhagic transformation (HT); 2) stem cell therapy: the repair of disrupted neuronal networks with newly born neurons in the chronic phase of ischemic stroke. Firstly, we estimated the vascular protective effect of a free radical scavenger, edaravone, in the tPA-treated rat model of middle cerebral artery occlusion. Edaravone prevented dramatically decreased the hemorrhagic transformation and improved the neurologic score and survival rate of tPA-treated rats. Secondly, we attempted to restore brain tissue using a novel biomaterial, polydimethysiloxane- tetraethoxysilane (PDMS-TEOS) hybrid with or without vascular endothelial growth factor (VEGF), and we could show that implantation of a PDMS-TEOS scaffold with VEGF might be effective for treating old brain infarction or trauma. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.

AB - Possible strategies for treating stroke include: 1) thrombolytic therapy with tissue plasminogen activator (tPA): restoring cerebral blood flow in the acute phase of ischemic stroke but sometimes causing hemorrhagic transformation (HT); 2) stem cell therapy: the repair of disrupted neuronal networks with newly born neurons in the chronic phase of ischemic stroke. Firstly, we estimated the vascular protective effect of a free radical scavenger, edaravone, in the tPA-treated rat model of middle cerebral artery occlusion. Edaravone prevented dramatically decreased the hemorrhagic transformation and improved the neurologic score and survival rate of tPA-treated rats. Secondly, we attempted to restore brain tissue using a novel biomaterial, polydimethysiloxane- tetraethoxysilane (PDMS-TEOS) hybrid with or without vascular endothelial growth factor (VEGF), and we could show that implantation of a PDMS-TEOS scaffold with VEGF might be effective for treating old brain infarction or trauma. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.

KW - Cerebral ischemia

KW - Free radicals

KW - Neural stem cells

KW - Scaffold

KW - Tissue plasminogen activator (tPA)

UR - http://www.scopus.com/inward/record.url?scp=79952525006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952525006&partnerID=8YFLogxK

U2 - 10.3727/096368910X532800

DO - 10.3727/096368910X532800

M3 - Article

VL - 20

SP - 95

EP - 97

JO - Cell Transplantation

JF - Cell Transplantation

SN - 0963-6897

IS - 1

ER -