Abstract
To clarify the role of histamine H1 receptors in allergic conjunctivitis, changes in vascular permeability of the conjunctiva were measured in histamine H1 receptor deficient mice. Wild-type mice showed a significant increase in vascular permeability of the conjunctiva induced by histamine. However, no such increase was found in histamine H1 receptor deficient mice. On the other hand, no differences were observed between wild-type and histamine H1 receptor deficient mice in response to serotonin. A significant increase in vascular permeability was observed in actively sensitized wild-type mice, whereas no increase was observed in histamine H1 receptor deficient mice. Similar findings were noted in passively sensitized animals. Histamine contents of the conjunctiva were significantly decreased by topical application of antigen in both wild-type and histamine H1 receptor deficient mice after active sensitization with antigen. These findings suggested that vascular permeability in the conjunctiva in allergic conjunctivitis is entirely regulated through histamine H1 receptor. (C) 2000 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 313-317 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 409 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Dec 15 2000 |
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Keywords
- 5-HT (5-hydroxytryptamine, serotonin)
- Allergic conjunctivitis
- Histamine
- Histamine H receptors
- Vascular permeability
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Vascular permeability in allergic conjunctivitis in mice lacking histamine H1 receptors. / Nakahara, Hiroto; Izushi, Keiji; Sugimoto, Yukio; Watanabe, Takeshi; Kamei, Chiaki.
In: European Journal of Pharmacology, Vol. 409, No. 3, 15.12.2000, p. 313-317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vascular permeability in allergic conjunctivitis in mice lacking histamine H1 receptors
AU - Nakahara, Hiroto
AU - Izushi, Keiji
AU - Sugimoto, Yukio
AU - Watanabe, Takeshi
AU - Kamei, Chiaki
PY - 2000/12/15
Y1 - 2000/12/15
N2 - To clarify the role of histamine H1 receptors in allergic conjunctivitis, changes in vascular permeability of the conjunctiva were measured in histamine H1 receptor deficient mice. Wild-type mice showed a significant increase in vascular permeability of the conjunctiva induced by histamine. However, no such increase was found in histamine H1 receptor deficient mice. On the other hand, no differences were observed between wild-type and histamine H1 receptor deficient mice in response to serotonin. A significant increase in vascular permeability was observed in actively sensitized wild-type mice, whereas no increase was observed in histamine H1 receptor deficient mice. Similar findings were noted in passively sensitized animals. Histamine contents of the conjunctiva were significantly decreased by topical application of antigen in both wild-type and histamine H1 receptor deficient mice after active sensitization with antigen. These findings suggested that vascular permeability in the conjunctiva in allergic conjunctivitis is entirely regulated through histamine H1 receptor. (C) 2000 Elsevier Science B.V.
AB - To clarify the role of histamine H1 receptors in allergic conjunctivitis, changes in vascular permeability of the conjunctiva were measured in histamine H1 receptor deficient mice. Wild-type mice showed a significant increase in vascular permeability of the conjunctiva induced by histamine. However, no such increase was found in histamine H1 receptor deficient mice. On the other hand, no differences were observed between wild-type and histamine H1 receptor deficient mice in response to serotonin. A significant increase in vascular permeability was observed in actively sensitized wild-type mice, whereas no increase was observed in histamine H1 receptor deficient mice. Similar findings were noted in passively sensitized animals. Histamine contents of the conjunctiva were significantly decreased by topical application of antigen in both wild-type and histamine H1 receptor deficient mice after active sensitization with antigen. These findings suggested that vascular permeability in the conjunctiva in allergic conjunctivitis is entirely regulated through histamine H1 receptor. (C) 2000 Elsevier Science B.V.
KW - 5-HT (5-hydroxytryptamine, serotonin)
KW - Allergic conjunctivitis
KW - Histamine
KW - Histamine H receptors
KW - Vascular permeability
UR - http://www.scopus.com/inward/record.url?scp=0034672618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034672618&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(00)00863-3
DO - 10.1016/S0014-2999(00)00863-3
M3 - Article
C2 - 11108826
AN - SCOPUS:0034672618
VL - 409
SP - 313
EP - 317
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -