Vascular endothelium of human dental pulp expresses diverse adhesion molecules for leukocyte emigration

Yoshihiko Sawa, S. Yoshida, K. I. Shibata, M. Suzuki, A. Mukaida

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The expression of adhesion molecules on the vascular endothelium of healthy and inflamed human dental pulp was studied immunohistochemically using antibodies for selectin family and immunoglobulin superfamily members. In healthy dental pulp, some vessels reacted very weakly with major histocompatibility complex (MHC) class II, and E- and P-selectin, and many vessels reacted with platelet-endothelial cell adhesion molecule-1 (PECAM-1), but no vessels reacted with intercellular adhesion molecule-1 (ICAM-1), ICAM-3 and vascular cell adhesion molecule-1 (VCAM-1). In inflamed pulp, a large number of vessels reacted strongly with MHC class II, E- and P-selectin, PECAM-1, ICAM-1, ICAM-3, and VCAM-1. This indicates that the vascular endothelium of the inflamed human dental pulp expresses diverse adhesion molecules for leukocyte emigration from the blood stream into tissue. Dental pulp is surrounded by dentin and isolated from other tissue, like an in vitro system, so dental pulp is an attractive model for studying the roles of adhesion molecules on the vascular endothelium in transendothelial migration of leukocytes.

Original languageEnglish
Pages (from-to)281-291
Number of pages11
JournalTissue and Cell
Volume30
Issue number2
DOIs
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Dental Pulp
Emigration and Immigration
Vascular Endothelium
Cell Adhesion Molecules
CD31 Antigens
P-Selectin
E-Selectin
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
Major Histocompatibility Complex
Transendothelial and Transepithelial Migration
Selectins
Dentin
Immunoglobulins
Leukocytes
Antibodies

Keywords

  • Adhesion molecules
  • Dental pulp
  • Immunohistochemistry
  • Leukocyte emigration
  • Transendothelial migration
  • Vascular endothelium

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Vascular endothelium of human dental pulp expresses diverse adhesion molecules for leukocyte emigration. / Sawa, Yoshihiko; Yoshida, S.; Shibata, K. I.; Suzuki, M.; Mukaida, A.

In: Tissue and Cell, Vol. 30, No. 2, 1998, p. 281-291.

Research output: Contribution to journalArticle

Sawa, Yoshihiko ; Yoshida, S. ; Shibata, K. I. ; Suzuki, M. ; Mukaida, A. / Vascular endothelium of human dental pulp expresses diverse adhesion molecules for leukocyte emigration. In: Tissue and Cell. 1998 ; Vol. 30, No. 2. pp. 281-291.
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