Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas

Hitoshi Nagatsuka; Kazuteru Hibi; Mehmet Gunduz; Hidetsugu Tsujigiwa; Ryou Tamamura; Toshio Sugahara; Akira Sasaki; Noriyuki Nagai

doi:10.1111/j.1600-0714.2004.00227.x

Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas

Hitoshi Nagatsuka, Kazuteru Hibi, Mehmet Gunduz, Hidetsugu Tsujigiwa, Ryou Tamamura, Toshio Sugahara, Akira Sasaki, Noriyuki Nagai

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

BACKGROUND: Intratumoral blood vessels are known to play an important role in cancer growth and metastasis. The discrepancy in previous reports using various endothelial markers individually suggested us to investigate both normal and various tumor areas with a wide panel of vascular markers. METHODS: Here, we used a panel of three antibodies (CD31, CD34, and endoglin) as blood vessel markers to investigate the distribution and properties of blood vessels in normal oral tissues and squamous cell carcinomas. RESULTS: Many microvessels with strong remodeling activity as well as undifferentiated tumoral vascular endothelial cells and immature endothelial cells were present in the cancer cell nest and marginal area of cancer infiltration. Our results showed different vascular distribution patterns using various immunostaining markers in normal and tumoral tissues. CONCLUSION: Vascular distribution and properties of endothelial cells appear to be closely associated with metastasis.

Original language	English
Pages (from-to)	70-76
Number of pages	7
Journal	Journal of Oral Pathology and Medicine
Volume	34
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0714.2004.00227.x
Publication status	Published - Feb 2005

Keywords

Angiogenesis
CD31
CD34
Endoglin
Oral cancer

ASJC Scopus subject areas

Pathology and Forensic Medicine
Oral Surgery
Otorhinolaryngology
Cancer Research
Periodontics

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas. / Nagatsuka, Hitoshi; Hibi, Kazuteru; Gunduz, Mehmet; Tsujigiwa, Hidetsugu; Tamamura, Ryou; Sugahara, Toshio; Sasaki, Akira; Nagai, Noriyuki.

In: Journal of Oral Pathology and Medicine, Vol. 34, No. 2, 02.2005, p. 70-76.

Research output: Contribution to journal › Article › peer-review

Nagatsuka, Hitoshi ; Hibi, Kazuteru ; Gunduz, Mehmet ; Tsujigiwa, Hidetsugu ; Tamamura, Ryou ; Sugahara, Toshio ; Sasaki, Akira ; Nagai, Noriyuki. / Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas. In: Journal of Oral Pathology and Medicine. 2005 ; Vol. 34, No. 2. pp. 70-76.

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abstract = "BACKGROUND: Intratumoral blood vessels are known to play an important role in cancer growth and metastasis. The discrepancy in previous reports using various endothelial markers individually suggested us to investigate both normal and various tumor areas with a wide panel of vascular markers. METHODS: Here, we used a panel of three antibodies (CD31, CD34, and endoglin) as blood vessel markers to investigate the distribution and properties of blood vessels in normal oral tissues and squamous cell carcinomas. RESULTS: Many microvessels with strong remodeling activity as well as undifferentiated tumoral vascular endothelial cells and immature endothelial cells were present in the cancer cell nest and marginal area of cancer infiltration. Our results showed different vascular distribution patterns using various immunostaining markers in normal and tumoral tissues. CONCLUSION: Vascular distribution and properties of endothelial cells appear to be closely associated with metastasis.",

keywords = "Angiogenesis, CD31, CD34, Endoglin, Oral cancer",

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AU - Nagatsuka, Hitoshi

AU - Hibi, Kazuteru

AU - Gunduz, Mehmet

AU - Tsujigiwa, Hidetsugu

AU - Tamamura, Ryou

AU - Sugahara, Toshio

AU - Sasaki, Akira

AU - Nagai, Noriyuki

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Y1 - 2005/2

N2 - BACKGROUND: Intratumoral blood vessels are known to play an important role in cancer growth and metastasis. The discrepancy in previous reports using various endothelial markers individually suggested us to investigate both normal and various tumor areas with a wide panel of vascular markers. METHODS: Here, we used a panel of three antibodies (CD31, CD34, and endoglin) as blood vessel markers to investigate the distribution and properties of blood vessels in normal oral tissues and squamous cell carcinomas. RESULTS: Many microvessels with strong remodeling activity as well as undifferentiated tumoral vascular endothelial cells and immature endothelial cells were present in the cancer cell nest and marginal area of cancer infiltration. Our results showed different vascular distribution patterns using various immunostaining markers in normal and tumoral tissues. CONCLUSION: Vascular distribution and properties of endothelial cells appear to be closely associated with metastasis.

AB - BACKGROUND: Intratumoral blood vessels are known to play an important role in cancer growth and metastasis. The discrepancy in previous reports using various endothelial markers individually suggested us to investigate both normal and various tumor areas with a wide panel of vascular markers. METHODS: Here, we used a panel of three antibodies (CD31, CD34, and endoglin) as blood vessel markers to investigate the distribution and properties of blood vessels in normal oral tissues and squamous cell carcinomas. RESULTS: Many microvessels with strong remodeling activity as well as undifferentiated tumoral vascular endothelial cells and immature endothelial cells were present in the cancer cell nest and marginal area of cancer infiltration. Our results showed different vascular distribution patterns using various immunostaining markers in normal and tumoral tissues. CONCLUSION: Vascular distribution and properties of endothelial cells appear to be closely associated with metastasis.

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KW - CD31

KW - CD34

KW - Endoglin

KW - Oral cancer

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Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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