Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas

Hitoshi Nagatsuka, Kazuteru Hibi, Mehmet Gunduz, Hidetsugu Tsujigiwa, Ryou Tamamura, Toshio Sugahara, Akira Sasaki, Noriyuki Nagai

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

BACKGROUND: Intratumoral blood vessels are known to play an important role in cancer growth and metastasis. The discrepancy in previous reports using various endothelial markers individually suggested us to investigate both normal and various tumor areas with a wide panel of vascular markers. METHODS: Here, we used a panel of three antibodies (CD31, CD34, and endoglin) as blood vessel markers to investigate the distribution and properties of blood vessels in normal oral tissues and squamous cell carcinomas. RESULTS: Many microvessels with strong remodeling activity as well as undifferentiated tumoral vascular endothelial cells and immature endothelial cells were present in the cancer cell nest and marginal area of cancer infiltration. Our results showed different vascular distribution patterns using various immunostaining markers in normal and tumoral tissues. CONCLUSION: Vascular distribution and properties of endothelial cells appear to be closely associated with metastasis.

Original languageEnglish
Pages (from-to)70-76
Number of pages7
JournalJournal of Oral Pathology and Medicine
Volume34
Issue number2
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Angiogenesis
  • CD31
  • CD34
  • Endoglin
  • Oral cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

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