Variations in the FTO gene are associated with severe obesity in the Japanese

Kikuko Hotta, Yoshio Nakata, Tomoaki Matsuo, Seika Kamohara, Kazuaki Kotani, Ryoya Komatsu, Naoto Itoh, Ikuo Mineo, Jun Wada, Hiroaki Masuzaki, Masato Yoneda, Atsushi Nakajima, Shigeru Miyazaki, Katsuto Tokunaga, Manabu Kawamoto, Tohru Funahashi, Kazuyuki Hamaguchi, Kentaro Yamada, Toshiaki Hanafusa, Shinichi Oikawa & 7 others Hironobu Yoshimatsu, Kazuwa Nakao, Toshiie Sakata, Yuji Matsuzawa, Kiyoji Tanaka, Naoyuki Kamatani, Yusuke Nakamura

Research output: Contribution to journalArticle

184 Citations (Scopus)

Abstract

Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1,527, BMI <25 kg/m2). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22-1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese.

Original languageEnglish
Pages (from-to)546-553
Number of pages8
JournalJournal of Human Genetics
Volume53
Issue number6
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Morbid Obesity
Obesity
Genes
Single Nucleotide Polymorphism
Phenotype
Body Mass Index
Linkage Disequilibrium
HDL Cholesterol
Hemoglobins
Triglycerides
Fats
Odds Ratio
Cholesterol
Genotype
Blood Pressure
Weights and Measures
Glucose

Keywords

  • Association
  • Fat-mass and obesity-associated gene
  • Japanese population
  • Obesity
  • SNP

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Hotta, K., Nakata, Y., Matsuo, T., Kamohara, S., Kotani, K., Komatsu, R., ... Nakamura, Y. (2008). Variations in the FTO gene are associated with severe obesity in the Japanese. Journal of Human Genetics, 53(6), 546-553. https://doi.org/10.1007/s10038-008-0283-1

Variations in the FTO gene are associated with severe obesity in the Japanese. / Hotta, Kikuko; Nakata, Yoshio; Matsuo, Tomoaki; Kamohara, Seika; Kotani, Kazuaki; Komatsu, Ryoya; Itoh, Naoto; Mineo, Ikuo; Wada, Jun; Masuzaki, Hiroaki; Yoneda, Masato; Nakajima, Atsushi; Miyazaki, Shigeru; Tokunaga, Katsuto; Kawamoto, Manabu; Funahashi, Tohru; Hamaguchi, Kazuyuki; Yamada, Kentaro; Hanafusa, Toshiaki; Oikawa, Shinichi; Yoshimatsu, Hironobu; Nakao, Kazuwa; Sakata, Toshiie; Matsuzawa, Yuji; Tanaka, Kiyoji; Kamatani, Naoyuki; Nakamura, Yusuke.

In: Journal of Human Genetics, Vol. 53, No. 6, 06.2008, p. 546-553.

Research output: Contribution to journalArticle

Hotta, K, Nakata, Y, Matsuo, T, Kamohara, S, Kotani, K, Komatsu, R, Itoh, N, Mineo, I, Wada, J, Masuzaki, H, Yoneda, M, Nakajima, A, Miyazaki, S, Tokunaga, K, Kawamoto, M, Funahashi, T, Hamaguchi, K, Yamada, K, Hanafusa, T, Oikawa, S, Yoshimatsu, H, Nakao, K, Sakata, T, Matsuzawa, Y, Tanaka, K, Kamatani, N & Nakamura, Y 2008, 'Variations in the FTO gene are associated with severe obesity in the Japanese', Journal of Human Genetics, vol. 53, no. 6, pp. 546-553. https://doi.org/10.1007/s10038-008-0283-1
Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, Komatsu R et al. Variations in the FTO gene are associated with severe obesity in the Japanese. Journal of Human Genetics. 2008 Jun;53(6):546-553. https://doi.org/10.1007/s10038-008-0283-1
Hotta, Kikuko ; Nakata, Yoshio ; Matsuo, Tomoaki ; Kamohara, Seika ; Kotani, Kazuaki ; Komatsu, Ryoya ; Itoh, Naoto ; Mineo, Ikuo ; Wada, Jun ; Masuzaki, Hiroaki ; Yoneda, Masato ; Nakajima, Atsushi ; Miyazaki, Shigeru ; Tokunaga, Katsuto ; Kawamoto, Manabu ; Funahashi, Tohru ; Hamaguchi, Kazuyuki ; Yamada, Kentaro ; Hanafusa, Toshiaki ; Oikawa, Shinichi ; Yoshimatsu, Hironobu ; Nakao, Kazuwa ; Sakata, Toshiie ; Matsuzawa, Yuji ; Tanaka, Kiyoji ; Kamatani, Naoyuki ; Nakamura, Yusuke. / Variations in the FTO gene are associated with severe obesity in the Japanese. In: Journal of Human Genetics. 2008 ; Vol. 53, No. 6. pp. 546-553.
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AU - Kotani, Kazuaki

AU - Komatsu, Ryoya

AU - Itoh, Naoto

AU - Mineo, Ikuo

AU - Wada, Jun

AU - Masuzaki, Hiroaki

AU - Yoneda, Masato

AU - Nakajima, Atsushi

AU - Miyazaki, Shigeru

AU - Tokunaga, Katsuto

AU - Kawamoto, Manabu

AU - Funahashi, Tohru

AU - Hamaguchi, Kazuyuki

AU - Yamada, Kentaro

AU - Hanafusa, Toshiaki

AU - Oikawa, Shinichi

AU - Yoshimatsu, Hironobu

AU - Nakao, Kazuwa

AU - Sakata, Toshiie

AU - Matsuzawa, Yuji

AU - Tanaka, Kiyoji

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N2 - Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese. To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) ≥ 30 kg/m2] and normal-weight control subjects (n = 1,527, BMI <25 kg/m2). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD) block of approximately 50 kb demonstrated significant associations with obesity; rs1558902 was most significantly associated with obesity. P value in additive mode was 0.0000041, and odds ratio (OR) adjusted for age and gender was 1.41 [95% confidential interval (CI) = 1.22-1.62]. Obesity-associated phenotypes, which include the level of plasma glucose, hemoglobin A1c, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure were not associated with the rs1558902 genotype. Thus, the SNPs in the FTO gene were found to be associated with obesity, i.e., severe obesity, in the Japanese.

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