Variable Expression of Epstein-Barr Virus Latent Membrane Protein I in Reed-Sternberg Cells of Hodgkin's Disease

Norihiro Teramoto, Liu Cao, Nobuhiro Kawasaki, Yuji Tonoyama, Ashit Baran Sarker, Tadashi Yoshino, Kiyoshi Takahashi, Tadaatsu Akagi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Reed-Sternberg cells (RS cells) of Hodgkin's disease (HD) are frequently infected with Epstein-Barr virus (EBV) and express EBV-encoded nonpolyadenylated RNA transcripts (EBER)-1. EBV latency has been classified into three distinct forms: Latency I, expressing only one of the latent proteins, EBV nuclear antigen (EBNA)-1, latency II, coexpressing EBNA-1 and LMPs, and latency III, expressing all latent viral proteins. RS cells express LMP-1 in addition to EBNA-1 and are considered to be in EBV latency II frequently encountered in nasopharyngeal carcinoma. We examined 13 cases of EBV-infected HD by combined EBER-1 in situ hybridization and immunostaining for LMP-1. All of the RS cells expressed EBER-1, but a substantial number of EBER-1 + RS cells were negative for LMP-1. The percentage of LMP-1 + RS cells out of EBER-1 + RS cells varied from 7% to 100% (average 69%). In this study, we showed that all EBV-infected RS cells were not restricted to latency II, and some belonged to latency I.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalActa medica Okayama
Volume50
Issue number5
Publication statusPublished - Oct 1 1996

Keywords

  • EBER-1
  • Immunohistochemistry
  • In situ hybridization
  • Latency

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Teramoto, N., Cao, L., Kawasaki, N., Tonoyama, Y., Sarker, A. B., Yoshino, T., Takahashi, K., & Akagi, T. (1996). Variable Expression of Epstein-Barr Virus Latent Membrane Protein I in Reed-Sternberg Cells of Hodgkin's Disease. Acta medica Okayama, 50(5), 267-270.