Abstract
Purpose: This multicenter study was conducted to evaluate the current variability of treatment planning of seed implantation in Japanese centers and the feasibility of two virtual trials. Methods and Materials: Two types of contour data were sent to 12 radiation oncologists with a request letter that asked them to make treatment plans on the data in the same manner as in their own practice. Five of the 12 radiation oncologists were asked to participate in the two virtual trials in which the D90 (dose to the hottest 90% of prostate volume) was 1) required to be set at just 180 Gy and 2) increased as much as possible without violating other limitations. Results: A relatively high dose with a small deviation was irradiated to the prostate in Japanese centers (mean D90 = 188 Gy; SD = 10 Gy). In the virtual trials, all five physicians could achieve 180 Gy for the D90 with a very small deviation, although the urethral dose showed relatively large deviations. Dose escalation without increase of urethral dose or V150 was difficult, although the rectum could be spared by most of the physicians. Conclusion: Our study showed a relatively high dose with a small deviation was prescribed to the prostate in Japanese centers. Consolidated protocols such as D90 = 180 Gy could be available for future trials. Meanwhile, our study suggested that some cautions might be needed for urethral dose and the V150, even when a relatively low D90 was requested.
| Original language | English |
|---|---|
| Journal | Brachytherapy |
| DOIs | |
| Publication status | Accepted/In press - Feb 21 2017 |
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Keywords
- Brachytherapy
- Low-dose-rate
- Prostate cancer
- Treatment plan
- Variability
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
Cite this
Variability of treatment planning of seed implantation : A Japanese multicenter simulation study. / Ishiyama, Hiromichi; Nakano, Masahiro; Toya, Kazuhito; Kota, Ryuichi; Kikuchi, Koyo; Yamaguchi, Takahiro; Kono, Naoaki; Kawakami, Shogo; Tsutsumi, Yuki; Tanaka, Tomoki; Eriguchi, Takahisa; Ohga, Saiji; Yamaguchi, Toshihiro; Takakawa, Yoshiaki; Morita, Masashi; Katayama, Norihisa; Ohashi, Toshio; Aoki, Manabu; Yorozu, Atsunori; Saito, Siro.
In: Brachytherapy, 21.02.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Variability of treatment planning of seed implantation
T2 - A Japanese multicenter simulation study
AU - Ishiyama, Hiromichi
AU - Nakano, Masahiro
AU - Toya, Kazuhito
AU - Kota, Ryuichi
AU - Kikuchi, Koyo
AU - Yamaguchi, Takahiro
AU - Kono, Naoaki
AU - Kawakami, Shogo
AU - Tsutsumi, Yuki
AU - Tanaka, Tomoki
AU - Eriguchi, Takahisa
AU - Ohga, Saiji
AU - Yamaguchi, Toshihiro
AU - Takakawa, Yoshiaki
AU - Morita, Masashi
AU - Katayama, Norihisa
AU - Ohashi, Toshio
AU - Aoki, Manabu
AU - Yorozu, Atsunori
AU - Saito, Siro
PY - 2017/2/21
Y1 - 2017/2/21
N2 - Purpose: This multicenter study was conducted to evaluate the current variability of treatment planning of seed implantation in Japanese centers and the feasibility of two virtual trials. Methods and Materials: Two types of contour data were sent to 12 radiation oncologists with a request letter that asked them to make treatment plans on the data in the same manner as in their own practice. Five of the 12 radiation oncologists were asked to participate in the two virtual trials in which the D90 (dose to the hottest 90% of prostate volume) was 1) required to be set at just 180 Gy and 2) increased as much as possible without violating other limitations. Results: A relatively high dose with a small deviation was irradiated to the prostate in Japanese centers (mean D90 = 188 Gy; SD = 10 Gy). In the virtual trials, all five physicians could achieve 180 Gy for the D90 with a very small deviation, although the urethral dose showed relatively large deviations. Dose escalation without increase of urethral dose or V150 was difficult, although the rectum could be spared by most of the physicians. Conclusion: Our study showed a relatively high dose with a small deviation was prescribed to the prostate in Japanese centers. Consolidated protocols such as D90 = 180 Gy could be available for future trials. Meanwhile, our study suggested that some cautions might be needed for urethral dose and the V150, even when a relatively low D90 was requested.
AB - Purpose: This multicenter study was conducted to evaluate the current variability of treatment planning of seed implantation in Japanese centers and the feasibility of two virtual trials. Methods and Materials: Two types of contour data were sent to 12 radiation oncologists with a request letter that asked them to make treatment plans on the data in the same manner as in their own practice. Five of the 12 radiation oncologists were asked to participate in the two virtual trials in which the D90 (dose to the hottest 90% of prostate volume) was 1) required to be set at just 180 Gy and 2) increased as much as possible without violating other limitations. Results: A relatively high dose with a small deviation was irradiated to the prostate in Japanese centers (mean D90 = 188 Gy; SD = 10 Gy). In the virtual trials, all five physicians could achieve 180 Gy for the D90 with a very small deviation, although the urethral dose showed relatively large deviations. Dose escalation without increase of urethral dose or V150 was difficult, although the rectum could be spared by most of the physicians. Conclusion: Our study showed a relatively high dose with a small deviation was prescribed to the prostate in Japanese centers. Consolidated protocols such as D90 = 180 Gy could be available for future trials. Meanwhile, our study suggested that some cautions might be needed for urethral dose and the V150, even when a relatively low D90 was requested.
KW - Brachytherapy
KW - Low-dose-rate
KW - Prostate cancer
KW - Treatment plan
KW - Variability
UR - http://www.scopus.com/inward/record.url?scp=85020637417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020637417&partnerID=8YFLogxK
U2 - 10.1016/j.brachy.2017.05.007
DO - 10.1016/j.brachy.2017.05.007
M3 - Article
C2 - 28623085
AN - SCOPUS:85020637417
JO - Brachytherapy
JF - Brachytherapy
SN - 1538-4721
ER -