Vancomycin-impregnated polymethylmethacrylate beads for methicillin- resistant Staphylococcus aureus (MRSA) infection: Report of two cases

Toshihumi Ozaki, Teruhito Yoshitaka, Toshiyuki Kunisada, Tomoyuki Dan'ura, Noriko Naito, Hajime Inoue

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Two patients with methicillin-resistant Staphylococcus aureus (MRSA) infection were treated with vancomycin (VCM)-impregnated polymethylmethacrylate (PMMA) beads. One patient, who had a history of polycystic kidney and diabetes mellitus, who was receiving hemodialysis due because of non-functional kidney, underwent resection of an intermediate grade chondrosarcoma in the pelvis. MRSA infection developed and curettage of the lesion was performed, but MRSA infection recurred. During the second revision surgery, VCM-impregnated PMMA beads were implanted. MRSA infection has not recurred for 16 months since the implantation of the VCM beads. The second patient had a history of total hip arthroplasty (THA) performed because of coxarthrosis. After the initial surgery, MRSA infection developed, recurring after the second revision surgery for THA. After curettage following removal of the prosthesis, VCM beads were implanted with a spacer composed of VCM-PMMA and a Luque rod. Infection did not recur and THA revision was performed 3 months after the VCM beads implantation. Fifteen months after the last revision surgery, infection has not recurred.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalJournal of Orthopaedic Science
Volume3
Issue number3
DOIs
Publication statusPublished - 1998

Fingerprint

Polymethyl Methacrylate
Vancomycin
Methicillin-Resistant Staphylococcus aureus
Infection
Reoperation
Arthroplasty
Hip
Curettage
Polycystic Kidney Diseases
Hip Osteoarthritis
Chondrosarcoma
Pelvis
Prostheses and Implants
Renal Dialysis
Diabetes Mellitus
Kidney

Keywords

  • Beads
  • Infection
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Polymethylmethacrylate (PMMA)
  • Vancomycin

ASJC Scopus subject areas

  • Surgery

Cite this

Vancomycin-impregnated polymethylmethacrylate beads for methicillin- resistant Staphylococcus aureus (MRSA) infection : Report of two cases. / Ozaki, Toshihumi; Yoshitaka, Teruhito; Kunisada, Toshiyuki; Dan'ura, Tomoyuki; Naito, Noriko; Inoue, Hajime.

In: Journal of Orthopaedic Science, Vol. 3, No. 3, 1998, p. 163-168.

Research output: Contribution to journalArticle

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