Valvular heart disease in Kawasaki syndrome: Incidence and natural history

Teiji Akagi, Hirohisa Kato, Osamu Inoue, Noboru Sato, Kou Imamura

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Abstract

To elucidate the incidence and natural history of valvular heart disease in Kawasaki syndrome, we analyzed patients who were found to have a new heart murmur after the onset of the disease. Among 1215 patients we found 13 (1.1%) with valvular disease (12 with mitral regurgitation and one with aortic regurgitation). We compared these patients with 30 who did not have valvular lesions. The duration of fever was longer and the incidence of coronary artery lesions significantly higher than in those without valvular disease. Heart murmurs disappeared within 2 months after the onset of valvular heart disease in five patients, whereas in another six, all involving valve prolapse, they persisted for 2 years or more. We postulate that two different mechanisms may be responsible for the variation in the duration of valvular heart disease: one, which disappeared spontaneously, was attributed to pancarditis; the other, which persisted, was due to dysfunction in valve and papillary muscles as a result of ischemia.

Original languageEnglish
Pages (from-to)366-372
Number of pages7
JournalAmerican Heart Journal
Volume120
Issue number2
DOIs
Publication statusPublished - 1990
Externally publishedYes

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Heart Valve Diseases
Mucocutaneous Lymph Node Syndrome
Natural History
Heart Murmurs
Incidence
Aortic Valve Insufficiency
Papillary Muscles
Prolapse
Mitral Valve Insufficiency
Coronary Vessels
Fever
Ischemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Valvular heart disease in Kawasaki syndrome : Incidence and natural history. / Akagi, Teiji; Kato, Hirohisa; Inoue, Osamu; Sato, Noboru; Imamura, Kou.

In: American Heart Journal, Vol. 120, No. 2, 1990, p. 366-372.

Research output: Contribution to journalArticle

Akagi, Teiji ; Kato, Hirohisa ; Inoue, Osamu ; Sato, Noboru ; Imamura, Kou. / Valvular heart disease in Kawasaki syndrome : Incidence and natural history. In: American Heart Journal. 1990 ; Vol. 120, No. 2. pp. 366-372.
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