Value of thallium-201 scintigraphy in bone and soft tissue tumors

Osamu Sato, Akira Kawai, Toshihumi Ozaki, Toshiyuki Kunisada, Tomoyuki Danura, Hajime Inoue

Research output: Contribution to journalArticle

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Abstract

The potential role of thallium-201 (201Tl) scintigraphy in the imaging of various musculoskeletal tumors was investigated in 80 patients. Uptake of 201Tl was observed in 17 (100%) malignant bone tumors, 6 (100%) giant cell tumors, and 2 of 8 (25%) benign bone tumors. Nineteen of 30 malignant soft tissue tumors (63%) were positive for 201Tl scintigraphy, while 2 of 14 benign soft tissue tumors (14%) yielded positive results. None of 6 liposarcomas were visualized by 201Tl scintigraphy. There was no 201Tl uptake in the tissues of 5 non-tumorous conditions. Ten patients with osteosarcoma were evaluated by 201Tl scintigraphy both pre- and post- chemotherapy. There was a significant correlation between changes in tumor- to-normal count ratio and percent necrosis of the resected tumor. The mean decrease in tumor-to-normal count ratio was 71% for patients with ≥90% tumor necrosis and 26% for those with 201Tl scintigraphy, with quantitative analysis of alterations in 201Tl uptake, may provide a quantitative and objective measure of the effect of preoperative chemotherapy in patients with malignant bone tumors.

Original languageEnglish
Pages (from-to)297-303
Number of pages7
JournalJournal of Orthopaedic Science
Volume3
Issue number6
DOIs
Publication statusPublished - 1998

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Thallium
Radionuclide Imaging
Bone and Bones
Neoplasms
Necrosis
Drug Therapy
Giant Cell Tumors
Liposarcoma
Osteosarcoma

Keywords

  • Tl-scintigraphy
  • Bone and soft tissue tumor
  • Histologic effect
  • Preoperative chemotherapy

ASJC Scopus subject areas

  • Surgery

Cite this

Value of thallium-201 scintigraphy in bone and soft tissue tumors. / Sato, Osamu; Kawai, Akira; Ozaki, Toshihumi; Kunisada, Toshiyuki; Danura, Tomoyuki; Inoue, Hajime.

In: Journal of Orthopaedic Science, Vol. 3, No. 6, 1998, p. 297-303.

Research output: Contribution to journalArticle

Sato, Osamu ; Kawai, Akira ; Ozaki, Toshihumi ; Kunisada, Toshiyuki ; Danura, Tomoyuki ; Inoue, Hajime. / Value of thallium-201 scintigraphy in bone and soft tissue tumors. In: Journal of Orthopaedic Science. 1998 ; Vol. 3, No. 6. pp. 297-303.
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