Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study

Takafumi Ueda, Norifumi Naka, Nobuhito Araki, Takeshi Ishii, Hiroyuki Tsuchiya, Hideki Yoshikawa, Kazuo Mochizuki, Tadao Tsuboyama, Junya Toguchida, Toshihumi Ozaki, Hiroaki Murata, Ikuo Kudawara, Kazuhiro Tanaka, Yukihide Iwamoto, Yasuo Yazawa, Kazuyoshi Kushida, Takanobu Otsuka, Keiji Sato

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Abstract

Background. The radiographic evaluation of the response to preoperative chemotherapy for bone and soft tissue sarcomas is based mostly on the change in primary tumor size before and after chemotherapy, as is done for many solid cancers. Its prognostic correlation, however, has hardly been validated. Methods. We conducted a retrospective validation study of the Japanese Orthopaedic Association (JOA) radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas as a JOA Committee on Musculoskeletal Tumors cooperative study. A total of 125 consecutive patients with high-grade bone (n = 77) and soft tissue (n = 48) sarcomas treated with neoadjuvant chemotherapy and definitive surgery in 25 tertiary referral hospitals were selected for the study. We investigated the correlation between the tumor size-based radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas provided by the JOA Committee on Musculoskeletal Tumors (hereafter called the JOA criteria) and the patients' overall survival using the Kaplan-Meier method and the log-rank test. Results. The JOA criteria correlated relatively well with survival for malignant bone tumors (mostly comprising osteosarcoma and Ewing's sarcoma) but not for soft tissue sarcomas, suggesting that the tumor size-based radiographic evaluation criteria for the response to preoperative chemotherapy in patients with soft tissue sarcomas is invalid. Conclusions. The JOA criteria, based on the change in primary tumor size, is valid for malignant bone tumors but invalid for soft tissue sarcomas. Other new evaluation modalities of the response to preoperative chemotherapy using innovative functional imaging techniques are needed for soft tissue sarcomas.

Original languageEnglish
Pages (from-to)304-312
Number of pages9
JournalJournal of Orthopaedic Science
Volume13
Issue number4
DOIs
Publication statusPublished - Jul 2008

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Sarcoma
Bone and Bones
Drug Therapy
Orthopedics
Neoplasms
Ewing's Sarcoma
Survival
Validation Studies
Osteosarcoma
Tertiary Care Centers
Retrospective Studies

ASJC Scopus subject areas

  • Surgery

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Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas : Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study. / Ueda, Takafumi; Naka, Norifumi; Araki, Nobuhito; Ishii, Takeshi; Tsuchiya, Hiroyuki; Yoshikawa, Hideki; Mochizuki, Kazuo; Tsuboyama, Tadao; Toguchida, Junya; Ozaki, Toshihumi; Murata, Hiroaki; Kudawara, Ikuo; Tanaka, Kazuhiro; Iwamoto, Yukihide; Yazawa, Yasuo; Kushida, Kazuyoshi; Otsuka, Takanobu; Sato, Keiji.

In: Journal of Orthopaedic Science, Vol. 13, No. 4, 07.2008, p. 304-312.

Research output: Contribution to journalArticle

Ueda, T, Naka, N, Araki, N, Ishii, T, Tsuchiya, H, Yoshikawa, H, Mochizuki, K, Tsuboyama, T, Toguchida, J, Ozaki, T, Murata, H, Kudawara, I, Tanaka, K, Iwamoto, Y, Yazawa, Y, Kushida, K, Otsuka, T & Sato, K 2008, 'Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study', Journal of Orthopaedic Science, vol. 13, no. 4, pp. 304-312. https://doi.org/10.1007/s00776-008-1235-5
Ueda, Takafumi ; Naka, Norifumi ; Araki, Nobuhito ; Ishii, Takeshi ; Tsuchiya, Hiroyuki ; Yoshikawa, Hideki ; Mochizuki, Kazuo ; Tsuboyama, Tadao ; Toguchida, Junya ; Ozaki, Toshihumi ; Murata, Hiroaki ; Kudawara, Ikuo ; Tanaka, Kazuhiro ; Iwamoto, Yukihide ; Yazawa, Yasuo ; Kushida, Kazuyoshi ; Otsuka, Takanobu ; Sato, Keiji. / Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas : Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study. In: Journal of Orthopaedic Science. 2008 ; Vol. 13, No. 4. pp. 304-312.
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abstract = "Background. The radiographic evaluation of the response to preoperative chemotherapy for bone and soft tissue sarcomas is based mostly on the change in primary tumor size before and after chemotherapy, as is done for many solid cancers. Its prognostic correlation, however, has hardly been validated. Methods. We conducted a retrospective validation study of the Japanese Orthopaedic Association (JOA) radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas as a JOA Committee on Musculoskeletal Tumors cooperative study. A total of 125 consecutive patients with high-grade bone (n = 77) and soft tissue (n = 48) sarcomas treated with neoadjuvant chemotherapy and definitive surgery in 25 tertiary referral hospitals were selected for the study. We investigated the correlation between the tumor size-based radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas provided by the JOA Committee on Musculoskeletal Tumors (hereafter called the JOA criteria) and the patients' overall survival using the Kaplan-Meier method and the log-rank test. Results. The JOA criteria correlated relatively well with survival for malignant bone tumors (mostly comprising osteosarcoma and Ewing's sarcoma) but not for soft tissue sarcomas, suggesting that the tumor size-based radiographic evaluation criteria for the response to preoperative chemotherapy in patients with soft tissue sarcomas is invalid. Conclusions. The JOA criteria, based on the change in primary tumor size, is valid for malignant bone tumors but invalid for soft tissue sarcomas. Other new evaluation modalities of the response to preoperative chemotherapy using innovative functional imaging techniques are needed for soft tissue sarcomas.",
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T1 - Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas

T2 - Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study

AU - Ueda, Takafumi

AU - Naka, Norifumi

AU - Araki, Nobuhito

AU - Ishii, Takeshi

AU - Tsuchiya, Hiroyuki

AU - Yoshikawa, Hideki

AU - Mochizuki, Kazuo

AU - Tsuboyama, Tadao

AU - Toguchida, Junya

AU - Ozaki, Toshihumi

AU - Murata, Hiroaki

AU - Kudawara, Ikuo

AU - Tanaka, Kazuhiro

AU - Iwamoto, Yukihide

AU - Yazawa, Yasuo

AU - Kushida, Kazuyoshi

AU - Otsuka, Takanobu

AU - Sato, Keiji

PY - 2008/7

Y1 - 2008/7

N2 - Background. The radiographic evaluation of the response to preoperative chemotherapy for bone and soft tissue sarcomas is based mostly on the change in primary tumor size before and after chemotherapy, as is done for many solid cancers. Its prognostic correlation, however, has hardly been validated. Methods. We conducted a retrospective validation study of the Japanese Orthopaedic Association (JOA) radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas as a JOA Committee on Musculoskeletal Tumors cooperative study. A total of 125 consecutive patients with high-grade bone (n = 77) and soft tissue (n = 48) sarcomas treated with neoadjuvant chemotherapy and definitive surgery in 25 tertiary referral hospitals were selected for the study. We investigated the correlation between the tumor size-based radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas provided by the JOA Committee on Musculoskeletal Tumors (hereafter called the JOA criteria) and the patients' overall survival using the Kaplan-Meier method and the log-rank test. Results. The JOA criteria correlated relatively well with survival for malignant bone tumors (mostly comprising osteosarcoma and Ewing's sarcoma) but not for soft tissue sarcomas, suggesting that the tumor size-based radiographic evaluation criteria for the response to preoperative chemotherapy in patients with soft tissue sarcomas is invalid. Conclusions. The JOA criteria, based on the change in primary tumor size, is valid for malignant bone tumors but invalid for soft tissue sarcomas. Other new evaluation modalities of the response to preoperative chemotherapy using innovative functional imaging techniques are needed for soft tissue sarcomas.

AB - Background. The radiographic evaluation of the response to preoperative chemotherapy for bone and soft tissue sarcomas is based mostly on the change in primary tumor size before and after chemotherapy, as is done for many solid cancers. Its prognostic correlation, however, has hardly been validated. Methods. We conducted a retrospective validation study of the Japanese Orthopaedic Association (JOA) radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas as a JOA Committee on Musculoskeletal Tumors cooperative study. A total of 125 consecutive patients with high-grade bone (n = 77) and soft tissue (n = 48) sarcomas treated with neoadjuvant chemotherapy and definitive surgery in 25 tertiary referral hospitals were selected for the study. We investigated the correlation between the tumor size-based radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas provided by the JOA Committee on Musculoskeletal Tumors (hereafter called the JOA criteria) and the patients' overall survival using the Kaplan-Meier method and the log-rank test. Results. The JOA criteria correlated relatively well with survival for malignant bone tumors (mostly comprising osteosarcoma and Ewing's sarcoma) but not for soft tissue sarcomas, suggesting that the tumor size-based radiographic evaluation criteria for the response to preoperative chemotherapy in patients with soft tissue sarcomas is invalid. Conclusions. The JOA criteria, based on the change in primary tumor size, is valid for malignant bone tumors but invalid for soft tissue sarcomas. Other new evaluation modalities of the response to preoperative chemotherapy using innovative functional imaging techniques are needed for soft tissue sarcomas.

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