Validation of formula-predicted glaucomatous optic disc appearances: The Glaucoma Stereo Analysis Study

Masaki Tanito, Koji Nitta, Maki Katai, Yasushi Kitaoka, Yu Yokoyama, Kazuko Omodaka, Tomoko Naito, Takehiro Yamashita, Shiro Mizoue, Aiko Iwase, Toru Nakazawa

Research output: Contribution to journalArticle

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Abstract

Aims: The Glaucoma Stereo Analysis Study (GSAS) is a multicentre collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. Using the GSAS dataset, we previously established a formula for predicting different appearances of glaucomatous optic discs, although the formula lacked validation in an independent dataset. In this study, the formula was validated in another testing dataset. Subjects and Methods: Testing dataset contained three-dimensionally analysed optic disc topographic parameters from 93 eyes with primary open-angle glaucoma; six topographic parameters (temporal and nasal rim-disc ratios, mean cup depth, height variation contour, disc tilt angle and rim decentring absolute value) were used for predicting different appearances of glaucomatous optic discs. The agreement between grader-classified optic disc types, that is, focal ischemic (FI), generalized enlargement, myopic glaucomatous (MY), and senile sclerotic (SS) and formula-predicted optic disc types, that is, pFI, pGE, pMY and pSS, were assessed. Results: Based on this formula, the eyes were classified with pFI (21 eyes, 22.6%), pGE (27 eyes, 29.0%), pMY (26 eyes, 28.0%) and pSS (19 eyes, 20.4%) when the top predictive element based on the formula was considered as the optic disc appearance in each eye. The six topographic parameters used in the formula differed significantly among the four predicted optic disc types. Substantial agreement (κ = 0.7496) was seen for the top two predictive elements based on the formula that agreed with the graders' classification in 76 (81.7%) eyes. Among the four optic disc types, the levels of agreement were relatively lower in the SS type (κ = 0.3863-0.5729) compared with the other three optic disc types (κ = 0.7898-0.8956) even though the unclassifiable and mixed optic disc types were excluded from the testing dataset. Conclusion: The GSAS classification formula can predict and quantify each component of different optic disc appearances in each eye and provide a novel parameter to describe glaucomatous optic disc characteristics.

Original languageEnglish
JournalActa Ophthalmologica
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Optic Disk
Glaucoma
Nose
Multicenter Studies
Datasets

Keywords

  • Diagnosis
  • Glaucomatous optic neuropathy
  • Open-angle glaucoma
  • Optic disc topography

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tanito, M., Nitta, K., Katai, M., Kitaoka, Y., Yokoyama, Y., Omodaka, K., ... Nakazawa, T. (Accepted/In press). Validation of formula-predicted glaucomatous optic disc appearances: The Glaucoma Stereo Analysis Study. Acta Ophthalmologica. https://doi.org/10.1111/aos.13816

Validation of formula-predicted glaucomatous optic disc appearances : The Glaucoma Stereo Analysis Study. / Tanito, Masaki; Nitta, Koji; Katai, Maki; Kitaoka, Yasushi; Yokoyama, Yu; Omodaka, Kazuko; Naito, Tomoko; Yamashita, Takehiro; Mizoue, Shiro; Iwase, Aiko; Nakazawa, Toru.

In: Acta Ophthalmologica, 01.01.2018.

Research output: Contribution to journalArticle

Tanito, M, Nitta, K, Katai, M, Kitaoka, Y, Yokoyama, Y, Omodaka, K, Naito, T, Yamashita, T, Mizoue, S, Iwase, A & Nakazawa, T 2018, 'Validation of formula-predicted glaucomatous optic disc appearances: The Glaucoma Stereo Analysis Study', Acta Ophthalmologica. https://doi.org/10.1111/aos.13816
Tanito, Masaki ; Nitta, Koji ; Katai, Maki ; Kitaoka, Yasushi ; Yokoyama, Yu ; Omodaka, Kazuko ; Naito, Tomoko ; Yamashita, Takehiro ; Mizoue, Shiro ; Iwase, Aiko ; Nakazawa, Toru. / Validation of formula-predicted glaucomatous optic disc appearances : The Glaucoma Stereo Analysis Study. In: Acta Ophthalmologica. 2018.
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abstract = "Aims: The Glaucoma Stereo Analysis Study (GSAS) is a multicentre collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. Using the GSAS dataset, we previously established a formula for predicting different appearances of glaucomatous optic discs, although the formula lacked validation in an independent dataset. In this study, the formula was validated in another testing dataset. Subjects and Methods: Testing dataset contained three-dimensionally analysed optic disc topographic parameters from 93 eyes with primary open-angle glaucoma; six topographic parameters (temporal and nasal rim-disc ratios, mean cup depth, height variation contour, disc tilt angle and rim decentring absolute value) were used for predicting different appearances of glaucomatous optic discs. The agreement between grader-classified optic disc types, that is, focal ischemic (FI), generalized enlargement, myopic glaucomatous (MY), and senile sclerotic (SS) and formula-predicted optic disc types, that is, pFI, pGE, pMY and pSS, were assessed. Results: Based on this formula, the eyes were classified with pFI (21 eyes, 22.6{\%}), pGE (27 eyes, 29.0{\%}), pMY (26 eyes, 28.0{\%}) and pSS (19 eyes, 20.4{\%}) when the top predictive element based on the formula was considered as the optic disc appearance in each eye. The six topographic parameters used in the formula differed significantly among the four predicted optic disc types. Substantial agreement (κ = 0.7496) was seen for the top two predictive elements based on the formula that agreed with the graders' classification in 76 (81.7{\%}) eyes. Among the four optic disc types, the levels of agreement were relatively lower in the SS type (κ = 0.3863-0.5729) compared with the other three optic disc types (κ = 0.7898-0.8956) even though the unclassifiable and mixed optic disc types were excluded from the testing dataset. Conclusion: The GSAS classification formula can predict and quantify each component of different optic disc appearances in each eye and provide a novel parameter to describe glaucomatous optic disc characteristics.",
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author = "Masaki Tanito and Koji Nitta and Maki Katai and Yasushi Kitaoka and Yu Yokoyama and Kazuko Omodaka and Tomoko Naito and Takehiro Yamashita and Shiro Mizoue and Aiko Iwase and Toru Nakazawa",
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AU - Katai, Maki

AU - Kitaoka, Yasushi

AU - Yokoyama, Yu

AU - Omodaka, Kazuko

AU - Naito, Tomoko

AU - Yamashita, Takehiro

AU - Mizoue, Shiro

AU - Iwase, Aiko

AU - Nakazawa, Toru

PY - 2018/1/1

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N2 - Aims: The Glaucoma Stereo Analysis Study (GSAS) is a multicentre collaborative study of the characteristics of glaucomatous optic disc morphology using a stereo fundus camera. Using the GSAS dataset, we previously established a formula for predicting different appearances of glaucomatous optic discs, although the formula lacked validation in an independent dataset. In this study, the formula was validated in another testing dataset. Subjects and Methods: Testing dataset contained three-dimensionally analysed optic disc topographic parameters from 93 eyes with primary open-angle glaucoma; six topographic parameters (temporal and nasal rim-disc ratios, mean cup depth, height variation contour, disc tilt angle and rim decentring absolute value) were used for predicting different appearances of glaucomatous optic discs. The agreement between grader-classified optic disc types, that is, focal ischemic (FI), generalized enlargement, myopic glaucomatous (MY), and senile sclerotic (SS) and formula-predicted optic disc types, that is, pFI, pGE, pMY and pSS, were assessed. Results: Based on this formula, the eyes were classified with pFI (21 eyes, 22.6%), pGE (27 eyes, 29.0%), pMY (26 eyes, 28.0%) and pSS (19 eyes, 20.4%) when the top predictive element based on the formula was considered as the optic disc appearance in each eye. The six topographic parameters used in the formula differed significantly among the four predicted optic disc types. Substantial agreement (κ = 0.7496) was seen for the top two predictive elements based on the formula that agreed with the graders' classification in 76 (81.7%) eyes. Among the four optic disc types, the levels of agreement were relatively lower in the SS type (κ = 0.3863-0.5729) compared with the other three optic disc types (κ = 0.7898-0.8956) even though the unclassifiable and mixed optic disc types were excluded from the testing dataset. Conclusion: The GSAS classification formula can predict and quantify each component of different optic disc appearances in each eye and provide a novel parameter to describe glaucomatous optic disc characteristics.

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KW - Diagnosis

KW - Glaucomatous optic neuropathy

KW - Open-angle glaucoma

KW - Optic disc topography

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