Vacuolar H+-atpase and the secondary transporters: Their identification, mechanism, function and physiological relevance

Yoshinori Moriyama

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1 Citation (Scopus)


Eukaryotic cells possess acidic compartments with pH ranging from 0.1-6.5. Studies in the last couple of decades indicated that the acid pool is established by vacuolar proton ATPase, and is essential for various physiological and pathological processes. I have identified the vacuolar ATPase as well as several secondary transporters which are ener-getically coupled with vacuolar ATPase. I have also established the protocol for analysis of the structure and function of transporter proteins applicable to essentially all known transporters. In this article, I am going to summarize this study and describe some topics.

Original languageEnglish
Pages (from-to)883-894
Number of pages12
JournalYakugaku Zasshi
Issue number7
Publication statusPublished - Jul 1 2015



  • Membrane protein
  • Pump
  • Transporter

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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