Abstract
Eukaryotic cells possess acidic compartments with pH ranging from 0.1-6.5. Studies in the last couple of decades indicated that the acid pool is established by vacuolar proton ATPase, and is essential for various physiological and pathological processes. I have identified the vacuolar ATPase as well as several secondary transporters which are ener-getically coupled with vacuolar ATPase. I have also established the protocol for analysis of the structure and function of transporter proteins applicable to essentially all known transporters. In this article, I am going to summarize this study and describe some topics.
| Original language | English |
|---|---|
| Pages (from-to) | 883-894 |
| Number of pages | 12 |
| Journal | Yakugaku Zasshi |
| Volume | 135 |
| Issue number | 7 |
| Publication status | Published - Jul 1 2015 |
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Keywords
- Membrane protein
- Pump
- Transporter
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
Cite this
Vacuolar H+-atpase and the secondary transporters : Their identification, mechanism, function and physiological relevance. / Moriyama, Yoshinori.
In: Yakugaku Zasshi, Vol. 135, No. 7, 01.07.2015, p. 883-894.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vacuolar H+-atpase and the secondary transporters
T2 - Their identification, mechanism, function and physiological relevance
AU - Moriyama, Yoshinori
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Eukaryotic cells possess acidic compartments with pH ranging from 0.1-6.5. Studies in the last couple of decades indicated that the acid pool is established by vacuolar proton ATPase, and is essential for various physiological and pathological processes. I have identified the vacuolar ATPase as well as several secondary transporters which are ener-getically coupled with vacuolar ATPase. I have also established the protocol for analysis of the structure and function of transporter proteins applicable to essentially all known transporters. In this article, I am going to summarize this study and describe some topics.
AB - Eukaryotic cells possess acidic compartments with pH ranging from 0.1-6.5. Studies in the last couple of decades indicated that the acid pool is established by vacuolar proton ATPase, and is essential for various physiological and pathological processes. I have identified the vacuolar ATPase as well as several secondary transporters which are ener-getically coupled with vacuolar ATPase. I have also established the protocol for analysis of the structure and function of transporter proteins applicable to essentially all known transporters. In this article, I am going to summarize this study and describe some topics.
KW - Membrane protein
KW - Pump
KW - Transporter
UR - http://www.scopus.com/inward/record.url?scp=84936108147&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84936108147&partnerID=8YFLogxK
M3 - Article
VL - 135
SP - 883
EP - 894
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
SN - 0031-6903
IS - 7
ER -