Abstract
Eukaryotic cells possess acidic compartments with pH ranging from 0.1-6.5. Studies in the last couple of decades indicated that the acid pool is established by vacuolar proton ATPase, and is essential for various physiological and pathological processes. I have identified the vacuolar ATPase as well as several secondary transporters which are ener-getically coupled with vacuolar ATPase. I have also established the protocol for analysis of the structure and function of transporter proteins applicable to essentially all known transporters. In this article, I am going to summarize this study and describe some topics.
| Original language | English |
|---|---|
| Pages (from-to) | 883-894 |
| Number of pages | 12 |
| Journal | Yakugaku Zasshi |
| Volume | 135 |
| Issue number | 7 |
| Publication status | Published - Jul 1 2015 |
Keywords
- Membrane protein
- Pump
- Transporter
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
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Moriyama, Y. (2015). Vacuolar H+-atpase and the secondary transporters: Their identification, mechanism, function and physiological relevance. Yakugaku Zasshi, 135(7), 883-894.