Abstract
Studies of the interactions between humans and pathogenic microorganisms require adequate representative animal infection models. Further, the availability of invertebrate models overcomes the ethical and financial issues of studying vertebrate materials. Insects have an innate immune system that is conserved in mammals. The recent utilization of silkworms as an animal infection model led to the identification of novel virulence genes of human pathogenic microorganisms and novel innate immune factors in the silkworm. The silkworm infection model is effective for identifying and evaluating novel factors involved in host-pathogen interactions.
| Original language | English |
|---|---|
| Pages (from-to) | 163-168 |
| Number of pages | 6 |
| Journal | Invertebrate Survival Journal |
| Volume | 9 |
| Issue number | 2 |
| Publication status | Published - Jan 1 2012 |
| Externally published | Yes |
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Keywords
- Bacteria
- Fungi
- Innate immune factor
- Insect model
- Virulence factor
ASJC Scopus subject areas
- Animal Science and Zoology
Cite this
Utilization of a silkworm model for understanding host-pathogen interactions. / Kaito, Chikara; Yoshikai, H.; Sekimizu, K.
In: Invertebrate Survival Journal, Vol. 9, No. 2, 01.01.2012, p. 163-168.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Utilization of a silkworm model for understanding host-pathogen interactions
AU - Kaito, Chikara
AU - Yoshikai, H.
AU - Sekimizu, K.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Studies of the interactions between humans and pathogenic microorganisms require adequate representative animal infection models. Further, the availability of invertebrate models overcomes the ethical and financial issues of studying vertebrate materials. Insects have an innate immune system that is conserved in mammals. The recent utilization of silkworms as an animal infection model led to the identification of novel virulence genes of human pathogenic microorganisms and novel innate immune factors in the silkworm. The silkworm infection model is effective for identifying and evaluating novel factors involved in host-pathogen interactions.
AB - Studies of the interactions between humans and pathogenic microorganisms require adequate representative animal infection models. Further, the availability of invertebrate models overcomes the ethical and financial issues of studying vertebrate materials. Insects have an innate immune system that is conserved in mammals. The recent utilization of silkworms as an animal infection model led to the identification of novel virulence genes of human pathogenic microorganisms and novel innate immune factors in the silkworm. The silkworm infection model is effective for identifying and evaluating novel factors involved in host-pathogen interactions.
KW - Bacteria
KW - Fungi
KW - Innate immune factor
KW - Insect model
KW - Virulence factor
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UR - http://www.scopus.com/inward/citedby.url?scp=84890550723&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:84890550723
VL - 9
SP - 163
EP - 168
JO - Invertebrate Survival Journal
JF - Invertebrate Survival Journal
SN - 1824-307X
IS - 2
ER -