Utilization of a silkworm model for understanding host-pathogen interactions

Chikara Kaito, H. Yoshikai, K. Sekimizu

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Studies of the interactions between humans and pathogenic microorganisms require adequate representative animal infection models. Further, the availability of invertebrate models overcomes the ethical and financial issues of studying vertebrate materials. Insects have an innate immune system that is conserved in mammals. The recent utilization of silkworms as an animal infection model led to the identification of novel virulence genes of human pathogenic microorganisms and novel innate immune factors in the silkworm. The silkworm infection model is effective for identifying and evaluating novel factors involved in host-pathogen interactions.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalInvertebrate Survival Journal
Volume9
Issue number2
Publication statusPublished - Jan 1 2012
Externally publishedYes

Fingerprint

host-pathogen relationships
silkworms
infection
microorganisms
animals
virulence
invertebrates
vertebrates
mammals
insects
genes

Keywords

  • Bacteria
  • Fungi
  • Innate immune factor
  • Insect model
  • Virulence factor

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Utilization of a silkworm model for understanding host-pathogen interactions. / Kaito, Chikara; Yoshikai, H.; Sekimizu, K.

In: Invertebrate Survival Journal, Vol. 9, No. 2, 01.01.2012, p. 163-168.

Research output: Contribution to journalReview article

@article{5de84a46aae147219dd2b9dcba0ca73d,
title = "Utilization of a silkworm model for understanding host-pathogen interactions",
abstract = "Studies of the interactions between humans and pathogenic microorganisms require adequate representative animal infection models. Further, the availability of invertebrate models overcomes the ethical and financial issues of studying vertebrate materials. Insects have an innate immune system that is conserved in mammals. The recent utilization of silkworms as an animal infection model led to the identification of novel virulence genes of human pathogenic microorganisms and novel innate immune factors in the silkworm. The silkworm infection model is effective for identifying and evaluating novel factors involved in host-pathogen interactions.",
keywords = "Bacteria, Fungi, Innate immune factor, Insect model, Virulence factor",
author = "Chikara Kaito and H. Yoshikai and K. Sekimizu",
year = "2012",
month = "1",
day = "1",
language = "English",
volume = "9",
pages = "163--168",
journal = "Invertebrate Survival Journal",
issn = "1824-307X",
publisher = "University of Modena and Reggio Emilia",
number = "2",

}

TY - JOUR

T1 - Utilization of a silkworm model for understanding host-pathogen interactions

AU - Kaito, Chikara

AU - Yoshikai, H.

AU - Sekimizu, K.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Studies of the interactions between humans and pathogenic microorganisms require adequate representative animal infection models. Further, the availability of invertebrate models overcomes the ethical and financial issues of studying vertebrate materials. Insects have an innate immune system that is conserved in mammals. The recent utilization of silkworms as an animal infection model led to the identification of novel virulence genes of human pathogenic microorganisms and novel innate immune factors in the silkworm. The silkworm infection model is effective for identifying and evaluating novel factors involved in host-pathogen interactions.

AB - Studies of the interactions between humans and pathogenic microorganisms require adequate representative animal infection models. Further, the availability of invertebrate models overcomes the ethical and financial issues of studying vertebrate materials. Insects have an innate immune system that is conserved in mammals. The recent utilization of silkworms as an animal infection model led to the identification of novel virulence genes of human pathogenic microorganisms and novel innate immune factors in the silkworm. The silkworm infection model is effective for identifying and evaluating novel factors involved in host-pathogen interactions.

KW - Bacteria

KW - Fungi

KW - Innate immune factor

KW - Insect model

KW - Virulence factor

UR - http://www.scopus.com/inward/record.url?scp=84890550723&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890550723&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:84890550723

VL - 9

SP - 163

EP - 168

JO - Invertebrate Survival Journal

JF - Invertebrate Survival Journal

SN - 1824-307X

IS - 2

ER -