Abstract
To clarify the effects of microwaves on pregnancy, uterine or uteroplacental blood flow and endocrine and biochemical mediators, including corticosterone, estradiol, prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α), were measured in rats exposed to continuous-wave (CW) microwave at 2 mW/cm2 incident power density at 2450 MHz for 90 min. Colonic temperature in virgin and pregnant rats was not significantly altered by microwave treatment. Microwaves decreased uteroplacental blood flow and increased progesterone and PGF2α in pregnant, but not in virgin rats. Intraperitoneal (i.p.) administration of angiotensin II, a uteroplacental vasodilator, before microwave exposure prevented the reduction in uteroplacental blood flow and the increased progesterone and PGF2α in pregnant rats. Increased corticosterone and decreased estradiol during microwave exposure were observed independent of pregnancy and pretreatment with angiotensin II. These results suggest that microwaves (CW, 2 mW/cm2, 2450 MHz) produce uteroplacental circulatory disturbances and ovarian and placental dysfunction during pregnancy, probably through nonthermal actions. The uteroplacental disturbances appear to be due to actions of PGF2α and may pose some risk for pregnancy. (C) 2000 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 235-240 |
| Number of pages | 6 |
| Journal | Reproductive Toxicology |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2000 |
| Externally published | Yes |
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Keywords
- Blood flow
- Microwave
- Placenta
- Pregnancy
- Progesterone
ASJC Scopus subject areas
- Toxicology
Cite this
Uteroplacental circulatory disturbance mediated by prostaglandin F(2α) in rats exposed to microwaves. / Nakamura, Hiroyuki; Nagase, Hirofumi; Ogino, Keiki; Hatta, Kotaro; Matsuzaki, Ichiyo.
In: Reproductive Toxicology, Vol. 14, No. 3, 05.2000, p. 235-240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Uteroplacental circulatory disturbance mediated by prostaglandin F(2α) in rats exposed to microwaves
AU - Nakamura, Hiroyuki
AU - Nagase, Hirofumi
AU - Ogino, Keiki
AU - Hatta, Kotaro
AU - Matsuzaki, Ichiyo
PY - 2000/5
Y1 - 2000/5
N2 - To clarify the effects of microwaves on pregnancy, uterine or uteroplacental blood flow and endocrine and biochemical mediators, including corticosterone, estradiol, prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α), were measured in rats exposed to continuous-wave (CW) microwave at 2 mW/cm2 incident power density at 2450 MHz for 90 min. Colonic temperature in virgin and pregnant rats was not significantly altered by microwave treatment. Microwaves decreased uteroplacental blood flow and increased progesterone and PGF2α in pregnant, but not in virgin rats. Intraperitoneal (i.p.) administration of angiotensin II, a uteroplacental vasodilator, before microwave exposure prevented the reduction in uteroplacental blood flow and the increased progesterone and PGF2α in pregnant rats. Increased corticosterone and decreased estradiol during microwave exposure were observed independent of pregnancy and pretreatment with angiotensin II. These results suggest that microwaves (CW, 2 mW/cm2, 2450 MHz) produce uteroplacental circulatory disturbances and ovarian and placental dysfunction during pregnancy, probably through nonthermal actions. The uteroplacental disturbances appear to be due to actions of PGF2α and may pose some risk for pregnancy. (C) 2000 Elsevier Science Inc.
AB - To clarify the effects of microwaves on pregnancy, uterine or uteroplacental blood flow and endocrine and biochemical mediators, including corticosterone, estradiol, prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α), were measured in rats exposed to continuous-wave (CW) microwave at 2 mW/cm2 incident power density at 2450 MHz for 90 min. Colonic temperature in virgin and pregnant rats was not significantly altered by microwave treatment. Microwaves decreased uteroplacental blood flow and increased progesterone and PGF2α in pregnant, but not in virgin rats. Intraperitoneal (i.p.) administration of angiotensin II, a uteroplacental vasodilator, before microwave exposure prevented the reduction in uteroplacental blood flow and the increased progesterone and PGF2α in pregnant rats. Increased corticosterone and decreased estradiol during microwave exposure were observed independent of pregnancy and pretreatment with angiotensin II. These results suggest that microwaves (CW, 2 mW/cm2, 2450 MHz) produce uteroplacental circulatory disturbances and ovarian and placental dysfunction during pregnancy, probably through nonthermal actions. The uteroplacental disturbances appear to be due to actions of PGF2α and may pose some risk for pregnancy. (C) 2000 Elsevier Science Inc.
KW - Blood flow
KW - Microwave
KW - Placenta
KW - Pregnancy
KW - Progesterone
UR - http://www.scopus.com/inward/record.url?scp=0034125173&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034125173&partnerID=8YFLogxK
U2 - 10.1016/S0890-6238(00)00073-3
DO - 10.1016/S0890-6238(00)00073-3
M3 - Article
VL - 14
SP - 235
EP - 240
JO - Reproductigve Toxicoloy
JF - Reproductigve Toxicoloy
SN - 0890-6238
IS - 3
ER -