Uteroplacental circulatory disturbance mediated by prostaglandin F(2α) in rats exposed to microwaves

Hiroyuki Nakamura, Hirofumi Nagase, Keiki Ogino, Kotaro Hatta, Ichiyo Matsuzaki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To clarify the effects of microwaves on pregnancy, uterine or uteroplacental blood flow and endocrine and biochemical mediators, including corticosterone, estradiol, prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α), were measured in rats exposed to continuous-wave (CW) microwave at 2 mW/cm2 incident power density at 2450 MHz for 90 min. Colonic temperature in virgin and pregnant rats was not significantly altered by microwave treatment. Microwaves decreased uteroplacental blood flow and increased progesterone and PGF2α in pregnant, but not in virgin rats. Intraperitoneal (i.p.) administration of angiotensin II, a uteroplacental vasodilator, before microwave exposure prevented the reduction in uteroplacental blood flow and the increased progesterone and PGF2α in pregnant rats. Increased corticosterone and decreased estradiol during microwave exposure were observed independent of pregnancy and pretreatment with angiotensin II. These results suggest that microwaves (CW, 2 mW/cm2, 2450 MHz) produce uteroplacental circulatory disturbances and ovarian and placental dysfunction during pregnancy, probably through nonthermal actions. The uteroplacental disturbances appear to be due to actions of PGF2α and may pose some risk for pregnancy. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalReproductive Toxicology
Volume14
Issue number3
DOIs
Publication statusPublished - May 2000
Externally publishedYes

Fingerprint

Prostaglandins F
Microwaves
Rats
Dinoprost
Pregnancy
Blood
Corticosterone
Angiotensin II
Progesterone
Estradiol
Vasodilator Agents
Dinoprostone
Temperature

Keywords

  • Blood flow
  • Microwave
  • Placenta
  • Pregnancy
  • Progesterone

ASJC Scopus subject areas

  • Toxicology

Cite this

Uteroplacental circulatory disturbance mediated by prostaglandin F(2α) in rats exposed to microwaves. / Nakamura, Hiroyuki; Nagase, Hirofumi; Ogino, Keiki; Hatta, Kotaro; Matsuzaki, Ichiyo.

In: Reproductive Toxicology, Vol. 14, No. 3, 05.2000, p. 235-240.

Research output: Contribution to journalArticle

Nakamura, Hiroyuki ; Nagase, Hirofumi ; Ogino, Keiki ; Hatta, Kotaro ; Matsuzaki, Ichiyo. / Uteroplacental circulatory disturbance mediated by prostaglandin F(2α) in rats exposed to microwaves. In: Reproductive Toxicology. 2000 ; Vol. 14, No. 3. pp. 235-240.
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