Uterine leiomyosarcoma arising in leiomyoma

Clinicopathological study of four cases and literature review: Original Article

Hiroyuki Yanai, Yoji Wani, Kenji Notohara, Shin Ichi Takada, Tadashi Yoshino

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In this study we examined four cases of leiomyosarcoma (LMS) arising in leiomyoma (LM). The patients ranged from 40 to 64 years old. Symptoms were unspecific and preoperative diagnosis of LMS had not been made. Size of the tumors ranged from 4 cm to 20.5 cm. All patients were in stage I and no patients developed recurrent disease. Histologically, the LMS component showed moderate to severe cytological atypia and an increased mitotic count in all cases. Tumor cell necrosis in the LMS was seen in three cases. Associated LM component was cellular in one case. The LMS component showed p53 expression in three of four cases and p16 expression was seen in two cases. The LM component lacked p53 expression in all cases and demonstrated p16 expression in two cases, including one case of cellular LM. In all cases, Ki-67-positive cells were less than 5% in the LM component and more than 25-30% in the LMS component. This study reveals that: (i) malignant transformation can occur even in relatively small LM; (ii) patients with LMS with an LM component have a favorable prognosis; and (iii) immunohistochemical examination of p53, p16 and Ki-67 is useful for identification of malignant focus.

Original languageEnglish
Pages (from-to)506-509
Number of pages4
JournalPathology International
Volume60
Issue number7
DOIs
Publication statusPublished - 2010

Fingerprint

Leiomyosarcoma
Leiomyoma
Neoplasms
Necrosis

Keywords

  • Ki-67
  • Leiomyoma
  • Leiomyosarcoma
  • P16
  • P53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Uterine leiomyosarcoma arising in leiomyoma : Clinicopathological study of four cases and literature review: Original Article. / Yanai, Hiroyuki; Wani, Yoji; Notohara, Kenji; Takada, Shin Ichi; Yoshino, Tadashi.

In: Pathology International, Vol. 60, No. 7, 2010, p. 506-509.

Research output: Contribution to journalArticle

@article{d7713d76b32b4e2ca187940d3e1c12a3,
title = "Uterine leiomyosarcoma arising in leiomyoma: Clinicopathological study of four cases and literature review: Original Article",
abstract = "In this study we examined four cases of leiomyosarcoma (LMS) arising in leiomyoma (LM). The patients ranged from 40 to 64 years old. Symptoms were unspecific and preoperative diagnosis of LMS had not been made. Size of the tumors ranged from 4 cm to 20.5 cm. All patients were in stage I and no patients developed recurrent disease. Histologically, the LMS component showed moderate to severe cytological atypia and an increased mitotic count in all cases. Tumor cell necrosis in the LMS was seen in three cases. Associated LM component was cellular in one case. The LMS component showed p53 expression in three of four cases and p16 expression was seen in two cases. The LM component lacked p53 expression in all cases and demonstrated p16 expression in two cases, including one case of cellular LM. In all cases, Ki-67-positive cells were less than 5{\%} in the LM component and more than 25-30{\%} in the LMS component. This study reveals that: (i) malignant transformation can occur even in relatively small LM; (ii) patients with LMS with an LM component have a favorable prognosis; and (iii) immunohistochemical examination of p53, p16 and Ki-67 is useful for identification of malignant focus.",
keywords = "Ki-67, Leiomyoma, Leiomyosarcoma, P16, P53",
author = "Hiroyuki Yanai and Yoji Wani and Kenji Notohara and Takada, {Shin Ichi} and Tadashi Yoshino",
year = "2010",
doi = "10.1111/j.1440-1827.2010.02549.x",
language = "English",
volume = "60",
pages = "506--509",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Uterine leiomyosarcoma arising in leiomyoma

T2 - Clinicopathological study of four cases and literature review: Original Article

AU - Yanai, Hiroyuki

AU - Wani, Yoji

AU - Notohara, Kenji

AU - Takada, Shin Ichi

AU - Yoshino, Tadashi

PY - 2010

Y1 - 2010

N2 - In this study we examined four cases of leiomyosarcoma (LMS) arising in leiomyoma (LM). The patients ranged from 40 to 64 years old. Symptoms were unspecific and preoperative diagnosis of LMS had not been made. Size of the tumors ranged from 4 cm to 20.5 cm. All patients were in stage I and no patients developed recurrent disease. Histologically, the LMS component showed moderate to severe cytological atypia and an increased mitotic count in all cases. Tumor cell necrosis in the LMS was seen in three cases. Associated LM component was cellular in one case. The LMS component showed p53 expression in three of four cases and p16 expression was seen in two cases. The LM component lacked p53 expression in all cases and demonstrated p16 expression in two cases, including one case of cellular LM. In all cases, Ki-67-positive cells were less than 5% in the LM component and more than 25-30% in the LMS component. This study reveals that: (i) malignant transformation can occur even in relatively small LM; (ii) patients with LMS with an LM component have a favorable prognosis; and (iii) immunohistochemical examination of p53, p16 and Ki-67 is useful for identification of malignant focus.

AB - In this study we examined four cases of leiomyosarcoma (LMS) arising in leiomyoma (LM). The patients ranged from 40 to 64 years old. Symptoms were unspecific and preoperative diagnosis of LMS had not been made. Size of the tumors ranged from 4 cm to 20.5 cm. All patients were in stage I and no patients developed recurrent disease. Histologically, the LMS component showed moderate to severe cytological atypia and an increased mitotic count in all cases. Tumor cell necrosis in the LMS was seen in three cases. Associated LM component was cellular in one case. The LMS component showed p53 expression in three of four cases and p16 expression was seen in two cases. The LM component lacked p53 expression in all cases and demonstrated p16 expression in two cases, including one case of cellular LM. In all cases, Ki-67-positive cells were less than 5% in the LM component and more than 25-30% in the LMS component. This study reveals that: (i) malignant transformation can occur even in relatively small LM; (ii) patients with LMS with an LM component have a favorable prognosis; and (iii) immunohistochemical examination of p53, p16 and Ki-67 is useful for identification of malignant focus.

KW - Ki-67

KW - Leiomyoma

KW - Leiomyosarcoma

KW - P16

KW - P53

UR - http://www.scopus.com/inward/record.url?scp=77953328963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953328963&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1827.2010.02549.x

DO - 10.1111/j.1440-1827.2010.02549.x

M3 - Article

VL - 60

SP - 506

EP - 509

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 7

ER -