Using indocyanine green fluorescent lymphography to demonstrate lymphatic architecture

Hiroo Suami, David Chang, Roman Skoracki, Kiyoshi Yamada, Yoshihiro Kimata

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Visualisation of the lymphatic system is a challenging task. Recently, an indocyanine green (ICG) fluorescent lymphography system was developed for visualising the lymphatic vessels. ICG emits energy in the near-infrared region between 840 and 850 nm when it is bound to protein in the tissue. Aim: To use ICG fluorescent lymphography to identify locations of the lymphatic vessel for lymphovenous shunt. Methods: The lymphatic anatomy in the upper extremity was investigated using ICG fluorescent lymphography in 3 healthy volunteers and 15 patients with breast cancer-related lymphoedema prior to them undergoing lymphaticovenular bypass. Results: In healthy volunteers, fluorescent images of lymphatic vessels emerged at the dorsal hand as a shiny linear pattern and ran longitudinally towards the proximal arm after a few minutes. In lymphoedema patients, the lymphatic vessels could be identified at the dorsal hand, but the appearance of the lymphatic structure varied between patients. Conclusions: ICG fluorescent lymphography allows for the prompt identification of the lymphatic vessels and has the potential to improve the outcomes of lymphovenous shunt operations and for use as a diagnostic tool.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalJournal of Lymphoedema
Volume7
Issue number2
Publication statusPublished - 2012

Fingerprint

Lymphography
Lymphatic Vessels
Indocyanine Green
Healthy Volunteers
Hand
Lymphatic System
Lymphedema
Upper Extremity
Anatomy
Arm
Proteins

Keywords

  • Breast cancer-related lymphoedema
  • Indocyanine green fluorescent lymphography
  • Lymphaticovenular shunt operation
  • Near-infrared radiation

ASJC Scopus subject areas

  • Hematology

Cite this

Using indocyanine green fluorescent lymphography to demonstrate lymphatic architecture. / Suami, Hiroo; Chang, David; Skoracki, Roman; Yamada, Kiyoshi; Kimata, Yoshihiro.

In: Journal of Lymphoedema, Vol. 7, No. 2, 2012, p. 25-29.

Research output: Contribution to journalArticle

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