Usefulness of lipoprotein (a) for predicting progression of non-culprit coronary lesions after acute myocardial infarction

Hiroki Ikenaga, Masaharu Ishihara, Ichiro Inoue, Takuji Kawagoe, Yuji Shimatani, Fumiharu Miura, Yasuharu Nakama, Kazuoki Dai, Takayuki Otani, Kentaro Ejiri, Nozomu Oda, Masayuki Nakamura, Takashi Miki

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Background: The serum lipoprotein (a) [Lp(a)] level is genetically determined and remains consistent during a person's life. Previous cohort studies have reported that subjects with a high Lp(a) level are at high risk of cardiac events. Methods and Results: This study consisted of 410 patients who underwent primary percutaneous coronary intervention within 24 h of the onset of acute myocardial infarction (AMI). Lp(a) was measured 1 week after AMI and patients were divided into 2 groups based: high Lp(a) group (>40 mg/dl, n=95) and low Lp(a) group (≤40 mg/dl, n= 315). A major adverse cardiac event (MACE) was defined as cardiac death, myocardial infarction and/or revascularization for new lesions. The incidence of MACE during 5 years was significantly higher in the high Lp(a) group than in the low Lp(a) group (34.7% vs. 16.5%, P<0.001). This difference was primarily driven by a higher incidence of new lesions requiring revascularization in the high Lp(a) group (31.6% vs. 15.2%, P<0.001). Multivariate analysis showed that Lp(a) was an independent predictor for MACE (odds ratio [OR] 1.64, 95% confidence interval [CI] 1.31-2.06, P<0.001) and revascularization of a new lesion (OR 1.61, 95%CI 1.32-2.13, P<0.001). Conclusions: Lp(a) levels could predict the progression of the non-culprit coronary lesions after AMI.

Original languageEnglish
Pages (from-to)2847-2852
Number of pages6
JournalCirculation Journal
Volume75
Issue number12
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Acute myocardial infarction
  • Lipoprotein (a)
  • Prognosis
  • Revascularization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Usefulness of lipoprotein (a) for predicting progression of non-culprit coronary lesions after acute myocardial infarction'. Together they form a unique fingerprint.

Cite this