Usefulness of high mobility group box 1 protein as a plasma biomarker in patient with peripheral artery disease

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Atherosclerosis is often associated with chronic vascular inflammation. High-mobility group box 1 protein (HMGB1) plays various roles, not only as a transcriptional regulatory factor in the nucleus, but also as an inflammatory mediator. A previous study suggested that flbrinogen is an important factor associated with atherosclerosis progression. The present study was performed to examine the levels of plasma HMGB1 protein in atherosclerosis patients. We studied 24 patients with peripheral artery disease (PAD) with atherosclerosis, and 10 healthy controls. We found that the concentrations of HMGB1 were increased in the plasma of the patients with atherosclerosis, and there were significant correlations between the plasma HMGB1 and flbrinogen levels. Plasma HMGB1 may play a key role in the pathogenesis of clinical and experimental atherosclerosis.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalActa Medica Okayama
Volume68
Issue number3
Publication statusPublished - 2014

Fingerprint

HMGB1 Protein
Peripheral Arterial Disease
Biomarkers
Atherosclerosis
Plasmas
Blood Vessels
Inflammation
Proteins

Keywords

  • Atherosclerosis disease
  • HMGB1
  • Peripheral artery fibrinogen

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Usefulness of high mobility group box 1 protein as a plasma biomarker in patient with peripheral artery disease. / Oozawa, Susumu; Sanoa, Shunji; Nishibori, Masahiro.

In: Acta Medica Okayama, Vol. 68, No. 3, 2014, p. 157-162.

Research output: Contribution to journalArticle

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